Academic Journal
Target-dependent routing of sensory information in the olfactory system.
| Τίτλος: | Target-dependent routing of sensory information in the olfactory system. |
|---|---|
| Συγγραφείς: | Le-Jahns K; Department of Chemosensation, RG Neuromodulation, Institute for Biology II, RWTH Aachen University, Aachen, Germany., Sireci S; Institute of Physiology, RG Neurophysiology and Optogenetics, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany., Mayland J; Institute for Physiology and Cell Biology, University of Veterinary Medicine, Hanover, Germany., Richter F; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hanover, Germany.; Center for Systems Neuroscience Hanover (ZSN), Hanover, Germany., Chamero P; Laboratoire de Physiologie de la Reproduction et des Comportements, INRAE-CNRS- University of Tours, Nouzilly, France., Schwarz MK; Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty, Bonn, Germany., Brunert D; Institute of Physiology, RG Neurophysiology and Optogenetics, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany., Rothermel M; Institute of Physiology, RG Neurophysiology and Optogenetics, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany. markus.rothermel@med.ovgu.de. |
| Πηγή: | Communications biology [Commun Biol] 2026 Oct 07; Vol. 9 (1). Date of Electronic Publication: 2026 Oct 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]- |
| Ιατρικοί όροι (MeSH): | Olfactory Bulb*/physiology , Olfactory Bulb*/cytology , Olfactory Pathways*/physiology , Olfactory Perception* , Smell*, Animals ; Mice ; Odorants ; Mice, Inbred C57BL ; Male |
| Περίληψη: | Parallel processing, the ability to split the information content of sensory stimuli and handle them simultaneously, is essential for sensory perception in many systems. Mitral (MCs) and tufted cells (TCs) in the olfactory bulb (OB), with their separate but overlapping projection areas, provide an ideal anatomical basis for parallel processing. Whether they convey different information to distinct areas of the olfactory cortex remains unclear. Here, we separated mouse OB output neurons by innervation area using retrograde tracing from the anterior olfactory nucleus (AON) or the anterior piriform cortex (APC). In vivo 2-photon calcium imaging in the OB revealed projection area-dependent differences, with APC-projecting neurons coding more strongly for odor concentration and more selectively for odor identity. This separation became more pronounced when differentially traced populations were split by cell type, with APC TCs displaying the strongest concentration-dependent changes in response and AON TCs showing very promiscuous odor tuning. Purely cell-type-derived properties did not explain the projection target-dependent differences in odor representation, as both mitral and tufted cells showed similar changes, and SVM classifier analysis demonstrated that classification by projection target outperformed classification by cell type. Our data suggests a prominent projection-defined separation of sensory information in the OB. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
| References: | Eur J Neurosci. 2003 Jun;17(11):2457-61. (PMID: 12814377) Nat Commun. 2018 Jul 16;9(1):2735. (PMID: 30013078) Front Cell Neurosci. 2020 Jul 16;14:220. (PMID: 32765224) J Neurophysiol. 2012 Oct;108(8):2323-37. (PMID: 22815406) IBRO Rep. 2020 Jul 22;9:157-163. (PMID: 32793841) Nature. 2012 Aug 16;488(7411):375-8. (PMID: 22820253) Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jun;69(6 Pt 2):066138. (PMID: 15244698) J Neurophysiol. 2001 Jan;85(1):169-73. (PMID: 11152717) Nature. 2014 Nov 13;515(7526):269-73. (PMID: 25383519) Elife. 2022 Jul 21;11:. (PMID: 35861321) Neuron. 2009 Jun 25;62(6):850-61. (PMID: 19555653) Nat Rev Neurosci. 2002 Nov;3(11):884-95. (PMID: 12415296) Bio Protoc. 2018 Sep 20;8(18):. (PMID: 30417031) Front Neural Circuits. 2010 Sep 23;4:. (PMID: 20941380) Cell. 2022 Oct 27;185(22):4117-4134.e28. (PMID: 36306734) Pain. 2024 May 1;165(5):1131-1141. (PMID: 38112748) Front Neural Circuits. 2021 Jan 06;14:607391. (PMID: 33488363) Neuron. 2015 Mar 04;85(5):942-58. (PMID: 25741722) J Neurosci. 2006 Jan 25;26(4):1247-59. (PMID: 16436612) Mol Psychiatry. 2023 Dec;28(12):5118-5127. (PMID: 37414924) J Physiol. 2014 May 15;592(10):2097-118. (PMID: 24614745) J Neurosci. 2013 Mar 20;33(12):5285-300. (PMID: 23516293) Sci Rep. 2020 Jul 1;10(1):10696. (PMID: 32612119) Hum Gene Ther. 2014 Aug;25(8):705-20. (PMID: 24694006) J Neurophysiol. 2024 Jun 1;131(6):1226-1239. (PMID: 38691531) Neuron. 2013 Mar 20;77(6):1122-35. (PMID: 23522047) J Neurosci. 2012 Jun 6;32(23):7970-85. (PMID: 22674272) J Neurosci. 2012 Feb 29;32(9):2964-75. (PMID: 22378870) PLoS One. 2013 Sep 27;8(9):e76310. (PMID: 24086725) J Neurosci. 2007 Feb 14;27(7):1534-42. (PMID: 17301162) J Comp Neurol. 1982 Jul 10;208(4):419-30. (PMID: 7119169) J Neurophysiol. 2004 Jun;91(6):2532-40. (PMID: 14960563) Physiol Rep. 2019 Nov;7(22):e14284. (PMID: 31782263) J Neurophysiol. 1981 Nov;46(5):918-31. (PMID: 6271931) Nat Commun. 2024 Jul 25;15(1):6274. (PMID: 39054324) Sci Adv. 2021 Mar 10;7(11):. (PMID: 33692111) Neuron. 2015 Jul 1;87(1):193-207. (PMID: 26139373) J Comp Neurol. 1980 Dec 1;194(3):519-34. (PMID: 7451680) Nat Neurosci. 2010 Oct;13(10):1276-82. (PMID: 20802489) Nat Commun. 2020 Mar 6;11(1):1246. (PMID: 32144256) Biomed Eng Online. 2003 May 17;2:13. (PMID: 12801419) J Neurobiol. 1999 Jan;38(1):93-104. (PMID: 10027565) Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5481-6. (PMID: 22431605) Front Neural Circuits. 2014 Nov 04;8:129. (PMID: 25408637) J Neurosci. 2013 Feb 6;33(6):2443-56. (PMID: 23392673) Neuron. 2012 Jul 26;75(2):320-9. (PMID: 22841316) J Neurophysiol. 1998 Mar;79(3):1425-40. (PMID: 9497422) J Neurosci. 2006 Nov 15;26(46):12023-32. (PMID: 17108176) Mol Ther. 2002 Jan;5(1):50-6. (PMID: 11786045) Elife. 2017 May 10;6:. (PMID: 28489003) J Neurophysiol. 1993 Jul;70(1):263-74. (PMID: 8395579) Nat Neurosci. 2008 Dec;11(12):1378-80. (PMID: 18978781) Nature. 2013 Jul 18;499(7458):295-300. (PMID: 23868258) Ann N Y Acad Sci. 2011 Mar;1220:106-16. (PMID: 21388408) J Neurophysiol. 1992 Aug;68(2):417-24. (PMID: 1527567) Neuron. 2001 Nov 20;32(4):723-35. (PMID: 11719211) Sci Adv. 2025 Oct 10;11(41):eadq8390. (PMID: 41061063) Neuron. 2016 Jul 20;91(2):397-411. (PMID: 27346531) PLoS One. 2012;7(4):e34926. (PMID: 22496877) Chem Senses. 2008 Nov;33(9):779-92. (PMID: 18635556) J Neurosci. 2012 Jan 4;32(1):85-98. (PMID: 22219272) Neuron. 2018 Jun 27;98(6):1214-1228.e5. (PMID: 29861286) eNeuro. 2019 Jun 27;6(3):. (PMID: 31209151) Nat Neurosci. 2000 Oct;3(10):1035-43. (PMID: 11017177) Neuron. 2015 Jun 17;86(6):1461-77. (PMID: 26051422) Elife. 2016 Jun 28;5:. (PMID: 27351103) J Neurophysiol. 1983 Aug;50(2):358-78. (PMID: 6886740) Annu Rev Neurosci. 2003;26:31-55. (PMID: 14527266) Neuron. 2016 May 4;90(3):609-21. (PMID: 27112498) J Neurophysiol. 1995 Feb;73(2):713-26. (PMID: 7760130) Cold Spring Harb Symp Quant Biol. 1990;55:599-610. (PMID: 2132840) Science. 2001 Feb 2;291(5505):889-94. (PMID: 11157170) Elife. 2026 Jun 09;13:. (PMID: 42261828) J Neurosci. 2021 Jul 28;41(30):6449-6467. (PMID: 34099512) Nat Neurosci. 2011 Nov 20;15(1):155-61. (PMID: 22101640) Science. 2024 Feb 2;383(6682):eadk8511. (PMID: 38301001) Curr Opin Neurobiol. 2020 Oct;64:96-102. (PMID: 32422571) Neuron. 2022 Dec 7;110(23):3970-3985.e7. (PMID: 36174573) PLoS Biol. 2024 Mar 1;22(3):e3002536. (PMID: 38427708) Nat Neurosci. 2014 Mar;17(3):407-15. (PMID: 24509429) J Neurosci. 2020 Sep 23;40(39):7379-7386. (PMID: 32968026) J Comp Neurol. 2019 Oct 1;527(14):2233-2244. (PMID: 30864157) Eur J Neurosci. 1992;4(9):813-822. (PMID: 12106304) Mol Ther. 2005 May;11(5):754-62. (PMID: 15851014) Brain Res. 1977 Jun 24;129(1):152-7. (PMID: 68803) Neuroscience. 2012 Oct 25;223:12-20. (PMID: 22871522) eNeuro. 2019 Aug 29;6(4):. (PMID: 31399493) Neuron. 2011 Nov 17;72(4):506-19. (PMID: 22099455) PLoS Biol. 2008 Apr 8;6(4):e82. (PMID: 18399719) Sci Rep. 2018 May 16;8(1):7625. (PMID: 29769664) Neuron. 2016 Apr 20;90(2):348-361. (PMID: 27041499) Front Neural Circuits. 2014 Sep 03;8:98. (PMID: 25232305) Nat Neurosci. 2007 May;10(5):631-9. (PMID: 17450136) J Neurophysiol. 2015 Jul;114(1):736-45. (PMID: 26041832) PLoS One. 2014 Oct 30;9(10):e109716. (PMID: 25356586) J Neurosci. 2007 Sep 12;27(37):9817-23. (PMID: 17855595) Science. 2018 Sep 14;361(6407):. (PMID: 30213885) Neuron. 2007 Oct 25;56(2):339-55. (PMID: 17964250) Neuron. 2017 Mar 8;93(5):1180-1197.e7. (PMID: 28238549) Neuroscience. 2011 Oct 13;193:249-58. (PMID: 21782903) Neuron. 2004 Apr 8;42(1):9-21. (PMID: 15066261) Elife. 2017 Apr 05;6:. (PMID: 28379135) Front Neural Circuits. 2024 Mar 08;18:1382626. (PMID: 38523698) J Neurophysiol. 2023 Jun 1;129(6):1515-1533. (PMID: 37222431) Elife. 2021 Jul 22;10:. (PMID: 34292150) Prog Neurobiol. 2023 Sep;228:102486. (PMID: 37343762) Sci Rep. 2011;1:50. (PMID: 22355569) PLoS One. 2014 Feb 19;9(2):e87357. (PMID: 24586270) J Neurosci. 2013 Sep 18;33(38):15195-206. (PMID: 24048849) Genesis. 2005 Sep;43(1):12-6. (PMID: 16106355) J Neurophysiol. 2003 Dec;90(6):3921-30. (PMID: 12917385) Front Neural Circuits. 2013 Sep 23;7:143. (PMID: 24068987) Elife. 2020 Jul 14;9:. (PMID: 32662420) J Comp Neurol. 1982 Aug 10;209(3):249-63. (PMID: 7130455) Front Neural Circuits. 2014 Jul 03;8:73. (PMID: 25071454) J Neurosci. 2020 Sep 16;40(38):7269-7285. (PMID: 32817250) Nat Neurosci. 2009 Feb;12(2):210-20. (PMID: 19151709) eNeuro. 2021 Sep 24;8(5):. (PMID: 34380657) J Neurosci. 2013 Apr 10;33(15):6594-602. (PMID: 23575856) Neuron. 2018 Aug 22;99(4):800-813.e6. (PMID: 30078580) Nature. 2011 Apr 14;472(7342):213-6. (PMID: 21451525) Nat Neurosci. 2016 Feb;19(2):271-82. (PMID: 26752161) Nat Rev Neurosci. 2009 May;10(5):360-72. (PMID: 19352403) Science. 2015 May 1;348(6234):560-3. (PMID: 25931556) Science. 2013 Apr 5;340(6128):1232627. (PMID: 23559255) |
| Grant Information: | 445965029/RO4046/5-1 Deutsche Forschungsgemeinschaft (German Research Foundation); 466488864/RO4046/6-1 Deutsche Forschungsgemeinschaft (German Research Foundation); 466488864/RO4046/7-1 Deutsche Forschungsgemeinschaft (German Research Foundation); 520287065/RO4046/8-1 Deutsche Forschungsgemeinschaft (German Research Foundation); 368482240/GRK2416 Deutsche Forschungsgemeinschaft (German Research Foundation); 362321501/GRK2413 Deutsche Forschungsgemeinschaft (German Research Foundation); 34697331/SCHW1578/2-2 Deutsche Forschungsgemeinschaft (German Research Foundation); 520287065/SCHW2100/1-1 Deutsche Forschungsgemeinschaft (German Research Foundation); SFB 1089 227953431 P02, P03, B06 Deutsche Forschungsgemeinschaft (German Research Foundation); ANR-20-CE92-0003 Agence Nationale de la Recherche (French National Research Agency) |
| Entry Date(s): | Date Created: 20261007 Date Completed: 20261008 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| PubMed Central ID: | PMC13646270 |
| DOI: | 10.1038/s42003-026-11071-5 |
| PMID: | 42844362 |
| Βάση Δεδομένων: | MEDLINE |
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