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Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.
Συγγραφείς: Zhou S; Civil and Environmental Engineering, Rice University, Houston, TX, USA., Philo SE; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA., Saldana MA; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA., Vela JD; Department of Civil and Environmental Engineering, Duke University, Durham, NC, USA., Smith AL; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA., Stadler LB; Civil and Environmental Engineering, Rice University, Houston, TX, USA. lauren.stadler@rice.edu.
Πηγή: Nature communications [Nat Commun] 2026 Sep 07; Vol. 17 (1). Date of Electronic Publication: 2026 Sep 07.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Imprint Name(s): Original Publication: [London] : Nature Pub. Group
Ιατρικοί όροι (MeSH): Plasmids*/genetics , Wastewater*/microbiology , Interspersed Repetitive Sequences*/genetics , Water Purification*, Sewage/microbiology ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Host Specificity/genetics ; Bacteria/genetics ; Gene Transfer, Horizontal ; Metagenomics
Περίληψη: Plasmids drive horizontal gene transfer and antimicrobial resistance spread in water resource recovery facilities, yet their in situ dynamics in complex microbial communities remain poorly characterized. We apply Hi-C metagenomics to resolve plasmid-host associations across influent, activated sludge, and effluent at three facilities. We identify 944 plasmid clusters with facility- and stage-specific distributions. Plasmid host range narrows from influent to effluent, indicating that treatment selectively constrains plasmid-host associations. Persistent plasmid clusters with detectable mobility markers show a trend toward broader, less modular host networks than those with no detected markers. Hi-C-supported antibiotic resistance gene associations highlight Burkholderiaceae and Rhodocyclaceae as prominent hosts of beta-lactam, tetracycline and sulfonamide resistance genes across facilities. These findings indicate that wastewater treatment narrows plasmid host range while maintaining dominant plasmid-carrying taxa and adaptive mobile elements, providing a framework for understanding plasmid persistence across treatment systems.
(© 2026. The Author(s).)
Competing Interests: Competing interests: The authors declare no competing interests.
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Grant Information: No. EEC-2133504 National Science Foundation (NSF); R21 AI190938 United States AI NIAID NIH HHS; W9132T-23-2-0002 United States Department of Defense | United States Army | U.S. Army Corps of Engineers (US Army Corps of Engineers); R21AI190938 U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID); NAS Grant G10001728 National Academies of Sciences, Engineering, and Medicine | National Academy of Sciences (NAS); W9132T-23-2-0002 United States Department of Defense | United States Army | US Army Corps of Engineers | Engineer Research and Development Center (U.S. Army Engineer Research and Development Center)
Substance Nomenclature: 0 (Wastewater)
0 (Sewage)
0 (Anti-Bacterial Agents)
Entry Date(s): Date Created: 20261007 Date Completed: 20261007 Latest Revision: 20261010
Update Code: 20261010
PubMed Central ID: PMC13646282
DOI: 10.1038/s41467-026-77447-7
PMID: 42844282
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1038/s41467-026-77447-7
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  Data: Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Civil and Environmental Engineering, Rice University, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Philo+SE%22">Philo SE</searchLink>; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saldana+MA%22">Saldana MA</searchLink>; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vela+JD%22">Vela JD</searchLink>; Department of Civil and Environmental Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Smith+AL%22">Smith AL</searchLink>; Sonny Astani Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stadler+LB%22">Stadler LB</searchLink>; Civil and Environmental Engineering, Rice University, Houston, TX, USA. lauren.stadler@rice.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Sep 07; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Sep 07.
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  Data: <i>Original Publication</i>: [London] : Nature Pub. Group
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  Data: <searchLink fieldCode="MM" term="%22Plasmids%22">Plasmids*</searchLink>/<searchLink fieldCode="MM" term="%22Plasmids+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Wastewater%22">Wastewater*</searchLink>/<searchLink fieldCode="MM" term="%22Wastewater+microbiology%22">microbiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Interspersed+Repetitive+Sequences%22">Interspersed Repetitive Sequences*</searchLink>/<searchLink fieldCode="MM" term="%22Interspersed+Repetitive+Sequences+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Water+Purification%22">Water Purification*</searchLink><br /><searchLink fieldCode="MH" term="%22Sewage%22">Sewage</searchLink>/<searchLink fieldCode="MH" term="%22Sewage+microbiology%22">microbiology</searchLink> ; <searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents</searchLink>/<searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Drug+Resistance%2C+Bacterial%22">Drug Resistance, Bacterial</searchLink>/<searchLink fieldCode="MH" term="%22Drug+Resistance%2C+Bacterial+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Host+Specificity%22">Host Specificity</searchLink>/<searchLink fieldCode="MH" term="%22Host+Specificity+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Bacteria%22">Bacteria</searchLink>/<searchLink fieldCode="MH" term="%22Bacteria+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Gene+Transfer%2C+Horizontal%22">Gene Transfer, Horizontal</searchLink> ; <searchLink fieldCode="MH" term="%22Metagenomics%22">Metagenomics</searchLink>
– Name: Abstract
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  Data: Plasmids drive horizontal gene transfer and antimicrobial resistance spread in water resource recovery facilities, yet their in situ dynamics in complex microbial communities remain poorly characterized. We apply Hi-C metagenomics to resolve plasmid-host associations across influent, activated sludge, and effluent at three facilities. We identify 944 plasmid clusters with facility- and stage-specific distributions. Plasmid host range narrows from influent to effluent, indicating that treatment selectively constrains plasmid-host associations. Persistent plasmid clusters with detectable mobility markers show a trend toward broader, less modular host networks than those with no detected markers. Hi-C-supported antibiotic resistance gene associations highlight Burkholderiaceae and Rhodocyclaceae as prominent hosts of beta-lactam, tetracycline and sulfonamide resistance genes across facilities. These findings indicate that wastewater treatment narrows plasmid host range while maintaining dominant plasmid-carrying taxa and adaptive mobile elements, providing a framework for understanding plasmid persistence across treatment systems.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
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  Data: 42844282
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-77447-7
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Sewage microbiology
        Type: general
      – SubjectFull: Anti-Bacterial Agents pharmacology
        Type: general
      – SubjectFull: Drug Resistance, Bacterial genetics
        Type: general
      – SubjectFull: Host Specificity genetics
        Type: general
      – SubjectFull: Bacteria genetics
        Type: general
      – SubjectFull: Gene Transfer, Horizontal
        Type: general
      – SubjectFull: Metagenomics
        Type: general
      – SubjectFull: Plasmids genetics
        Type: general
      – SubjectFull: Wastewater microbiology
        Type: general
      – SubjectFull: Interspersed Repetitive Sequences genetics
        Type: general
      – SubjectFull: Water Purification
        Type: general
    Titles:
      – TitleFull: Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhou S
      – PersonEntity:
          Name:
            NameFull: Philo SE
      – PersonEntity:
          Name:
            NameFull: Saldana MA
      – PersonEntity:
          Name:
            NameFull: Vela JD
      – PersonEntity:
          Name:
            NameFull: Smith AL
      – PersonEntity:
          Name:
            NameFull: Stadler LB
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 07
              M: 09
              Text: 2026 Sep 07
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1