Academic Journal
High prevalence of Plasmodium ovalewallikeri in co-infections with Plasmodium falciparum in symptomatic than asymptomatic Plasmodium parasite infections in Kisumu, Kenya.
| Τίτλος: | High prevalence of Plasmodium ovalewallikeri in co-infections with Plasmodium falciparum in symptomatic than asymptomatic Plasmodium parasite infections in Kisumu, Kenya. |
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| Συγγραφείς: | Juma JA; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Watson OJ; Department of Infectious Disease Epidemiology, Medical Research Council, Centre for Global Infectious Disease Analysis, Imperial College London, London, England., Juma DW; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Opot BH; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Chemwor G; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Mutahi M; The Kenya Medical Research Institute (KEMRI) / Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Okoth R; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Mwakio EW; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Yeda R; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Okello CO; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Cheruiyot A; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Omariba D; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Dayo L; Department of Health County Government of Kisumu, Ministry of Health, Nairobi, Kenya., Ogola HA; Department of Health County Government of Kisumu, Ministry of Health, Nairobi, Kenya., Biwott G; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Adega C; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Oluoch F; Department of Health County Government of Kisumu, Ministry of Health, Nairobi, Kenya., Omondi V; Department of Health County Government of Kisumu, Ministry of Health, Nairobi, Kenya., Otieno G; Department of Health County Government of Kisumu, Ministry of Health, Nairobi, Kenya., Kamau E; Department of Pathology and Laboratory Medicine, Tripler Amy Medical Center, Honolulu, Hawaii, United States of America., Andagalu B; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Sifuna P; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya., Roth A; Medical Communications for Combat Casualty Care, Fort Detrick, Maryland, United States of America., Khagayi S; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Garges EC; Walter Reed Army Institute of Research-Africa, Nairobi, Kenya., Ogutu B; Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya., Akala HM; Department of Emerging and Infectious Diseases, Walter Reed Army Institute of Research-Africa/Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya. |
| Πηγή: | PloS one [PLoS One] 2026 Oct 07; Vol. 21 (10), pp. e0334188. Date of Electronic Publication: 2026 Oct 07 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| Ιατρικοί όροι (MeSH): | Coinfection*/epidemiology , Coinfection*/parasitology , Plasmodium falciparum*/genetics , Plasmodium falciparum*/isolation & purification , Malaria, Falciparum*/epidemiology , Malaria, Falciparum*/parasitology , Malaria*/epidemiology , Malaria*/parasitology, Kenya/epidemiology ; Asymptomatic Infections/epidemiology ; Plasmodium/genetics ; Humans ; Prevalence ; Female ; Cross-Sectional Studies ; Male ; Adult ; Child ; Child, Preschool ; Adolescent ; Young Adult ; Middle Aged ; Infant |
| Περίληψη: | Plasmodium falciparum (Pf), Plasmodium ovalewallikeri (Pow), Plasmodium ovalecurtisi (Poc), and Plasmodium malariae (Pm) coexists in Kenya sympatrically. Some infections progress to classical symptoms of malaria prompting hospital visits, while others remain asymptomatic. There is limited information on whether the species composition status of infections in endemic areas influences progression to either asymptomatic or symptomatic infection. This cross-sectional study determined the composition of Plasmodium species among symptomatic versus asymptomatic participants in Kombewa, Kenya. Between 2015 and 2016, samples from 741 individuals, comprising of 437 from symptomatic participants at Kombewa Subcounty hospital and 304 from asymptomatic participants from within Kombewa Subcounty hospital's catchment area were analyzed for Plasmodium species composition using real-time qPCR assay targeting the small subunit ribosomal RNA (ssrRNA) gene. R Studio was used to describe Plasmodium species prevalence, and the odds of occurring within a given infection presentation. Co-infection analysis revealed 741 samples predominantly contained Pf 655/741 (88.3%) followed by Pow 153/741 (20.6%), Pm 70/741 (9.4%) and Poc 64/741 (8.6%); 12/741 (1.62%) samples did not amplify any species. A total of 535/741 (72.2%) samples contained single species, and 194/741 (26.18%) samples contained multiple species. Species distribution differed significantly, with Pf and Pow more prevalent in symptomatic cases, while Pm and Poc were more common in asymptomatic individuals (p = 0.000). Pm and Poc single-species infections occurred among asymptomatic infections only. There were significantly higher odds of multiple species occurrence for infections containing Pf/Pow 92 (95.8%) among symptomatic than asymptomatic infections (OR 1.5, 95% CI [1.36-1.65], p = 0.000). Overall, mixed-species infections involving Pf and Pow were significantly more common in symptomatic individuals, posing a risk of false diagnosis by Pf-Histidine-Rich Protein 2 test. This underscores the need for deployment of interventions that target all Plasmodium species. These findings on the burden across symptomatic vs asymptomatic infections suggest a need for determination of the role of species composition in disease progression. (Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Entry Date(s): | Date Created: 20261007 Date Completed: 20261007 Latest Revision: 20261009 |
| Update Code: | 20261009 |
| PubMed Central ID: | PMC13645224 |
| DOI: | 10.1371/journal.pone.0334188 |
| PMID: | 42842695 |
| Βάση Δεδομένων: | MEDLINE |
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