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Ageing processes in the bonobo gut microbiome mirror human patterns.

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Τίτλος: Ageing processes in the bonobo gut microbiome mirror human patterns.
Συγγραφείς: Torfs JRR; Behavioural Ecology and Ecophysiology Research Group, Department of Biology, University of Antwerp, Antwerp, Belgium. jonas.torfs@uantwerpen.be.; Zoo Antwerp Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium. jonas.torfs@uantwerpen.be.; Laboratory of Applied Microbiology and Biotechnology, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium. jonas.torfs@uantwerpen.be., Kreyer M; Zoo Antwerp Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium.; Max-Planck Institute of Animal Behavior, Konstanz, Germany., Wittouck S; Laboratory of Applied Microbiology and Biotechnology, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium., Ahannach S; Laboratory of Applied Microbiology and Biotechnology, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.; U-MaMi Centre of Excellence, University of Antwerp, Antwerp, Belgium., Lebeer S; Laboratory of Applied Microbiology and Biotechnology, Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium.; U-MaMi Centre of Excellence, University of Antwerp, Antwerp, Belgium., Eens M; Behavioural Ecology and Ecophysiology Research Group, Department of Biology, University of Antwerp, Antwerp, Belgium., Fruth B; Zoo Antwerp Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium.; Max-Planck Institute of Animal Behavior, Konstanz, Germany., Staes N; Behavioural Ecology and Ecophysiology Research Group, Department of Biology, University of Antwerp, Antwerp, Belgium.; Zoo Antwerp Centre for Research and Conservation, Royal Zoological Society of Antwerp, Antwerp, Belgium.
Πηγή: NPJ biofilms and microbiomes [NPJ Biofilms Microbiomes] 2026 Sep 03; Vol. 12 (1). Date of Electronic Publication: 2026 Sep 03.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101666944 Publication Model: Electronic Cited Medium: Internet ISSN: 2055-5008 (Electronic) Linking ISSN: 20555008 NLM ISO Abbreviation: NPJ Biofilms Microbiomes Subsets: MEDLINE
Imprint Name(s): Original Publication: [New York, NY ?] : Nature Publishing Group, [2015]-
Ιατρικοί όροι (MeSH): Pan paniscus*/microbiology , Bacteria*/classification , Bacteria*/genetics , Bacteria*/isolation & purification , Aging* , Gastrointestinal Microbiome*, RNA, Ribosomal, 16S/genetics ; Animals, Zoo/microbiology ; Feces/microbiology ; Animals ; Humans ; Biodiversity ; Aged
Περίληψη: Ageing is associated with changes in the human gut bacterial microbiome: with age, it becomes more diverse, intra- and interindividual variability increases and it shows a decline in core bacterial genera and an expansion of rarer genera. While recent evidence in model organisms suggests these patterns may arise through stochastic processes rather than host-driven selection, the role of life-time exposures, or the exposome, remains poorly understood. Here, we characterise age-related gut microbiome dynamics in 165 bonobos (Pan paniscus) from wild and zoo-housed populations, aged 2 to 71 years, providing a comparative framework to disentangle conserved from context-dependent ageing trajectories in the gut microbiome in hominids. Across both environments, ageing was associated with increased microbial diversity and reduced core microbiome abundance, paralleled by a rise in low-abundance taxa, recapitulating patterns seen in humans. Notably, instability and uniqueness increased with age in zoo-housed, but not wild bonobos, mirroring patterns restricted to industrialised human populations. Moreover, cumulative exposure to distinct environments over an individual's lifetime substantially contributes to microbiome uniqueness. Our findings suggest that while gut microbiome ageing is broadly conserved across hominids, its expression is modulated by environmental context, offering insight into the evolutionary and ecological drivers of microbial ageing in humans.
(© 2026. The Author(s).)
Competing Interests: Competing interests: S.L. declares to be a voluntary academic board member of the International Scientific Association on Probiotics and Prebiotics (ISAPP, www.isappscience.org ), cofounder of YUN, and scientific advisor for Freya Biosciences. S.L. serves as Guest Editor of npj Biofilms and Microbiomes but had no involvement in the peer review process or the decision to publish this paper. S.A. declares to be a voluntary member of the student and fellows’ association of ISAPP. None of these organisations or companies were involved in the design or data analysis of this study, which was fully funded by university, governmental, and European funding. The other authors do not have a competing interest.
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Grant Information: 1124921N Fonds Wetenschappelijk Onderzoek; 12AZ624N Fonds Wetenschappelijk Onderzoek; S006424N Fonds Wetenschappelijk Onderzoek; 1249124N Fonds Wetenschappelijk Onderzoek; DOCPRO37054 Universiteit Antwerpen; Lacto-Be 852600 HORIZON EUROPE European Research Council
Substance Nomenclature: 0 (RNA, Ribosomal, 16S)
Entry Date(s): Date Created: 20261006 Date Completed: 20261006 Latest Revision: 20261009
Update Code: 20261009
PubMed Central ID: PMC13642333
DOI: 10.1038/s41522-026-01032-5
PMID: 42838993
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2055-5008
DOI:10.1038/s41522-026-01032-5