Academic Journal
Advances in the Phenotyping and Management of Common Variable Immunodeficiency.
| Τίτλος: | Advances in the Phenotyping and Management of Common Variable Immunodeficiency. |
|---|---|
| Συγγραφείς: | Gill ME; Clinical Immunodeficiency Program, Beth Israel Lahey Health, Division of Allergy & Immunology, Lahey Clinic, Burlington, MA, USA., Jogdand A; Clinical Immunodeficiency Program, Beth Israel Lahey Health, Division of Allergy & Immunology, Lahey Clinic, Burlington, MA, USA., Schissel C; Translational Research Program, Division of Allergy & Immunology, Lahey Clinic, Burlington, MA, USA., Ong MS; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA., Barmettler S; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA., Farmer JR; Clinical Immunodeficiency Program, Beth Israel Lahey Health, Division of Allergy & Immunology, Lahey Clinic, Burlington, MA, USA; Department of Medicine, UMass Chan Medical School, Lahey Clinic, Burlington, MA, USA. Electronic address: jocelyn.farmer@lahey.org. |
| Πηγή: | Immunology and allergy clinics of North America [Immunol Allergy Clin North Am] 2026 Nov; Vol. 46 (4), pp. 699-721. Date of Electronic Publication: 2026 Aug 05. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8805635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8607 (Electronic) Linking ISSN: 08898561 NLM ISO Abbreviation: Immunol Allergy Clin North Am Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia : W.B. Saunders, c1987- |
| Ιατρικοί όροι (MeSH): | Common Variable Immunodeficiency*/diagnosis , Common Variable Immunodeficiency*/therapy , Common Variable Immunodeficiency*/etiology , Common Variable Immunodeficiency*/immunology, Humans ; Phenotype ; Disease Management ; Immunophenotyping |
| Περίληψη: | This article highlights advances in the phenotyping and management of common variable immunodeficiency (CVID). Advances in phenotyping include the use of cell-based, soluble, and genetic profiling, combined with novel applications like machine learning, to better define high-risk (complicated CVID) and low-risk (uncomplicated CVID) patient populations. Advances in management include first-in-class clinical trials to treat noninfectious disease manifestations based on convergent pathways of immune dysregulation in CVID. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosure J.R. Farmer is an ongoing consultant for Pharming and has received investigator-initiated research grants from Pfizer, United States, Bristol Myers Squibb, United States, and Pharming, Netherlands with no direct relation to the study presented. |
| Contributed Indexing: | Keywords: Advances; Common variable immunodeficiency (CVID); Complicated common variable immunodeficiency (CVIDc); Diagnosis; Management; Noninfectious complications; Phenotype; Uncomplicated common variable immunodeficiency (CVIDu) |
| Entry Date(s): | Date Created: 20261005 Date Completed: 20261005 Latest Revision: 20261005 |
| Update Code: | 20261006 |
| DOI: | 10.1016/j.iac.2026.06.011 |
| PMID: | 42833749 |
| Βάση Δεδομένων: | MEDLINE |
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