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Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic.

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Title: Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic.
Authors: Gößwein M; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Ulmert I; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Rosshart SP; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Coquet JM; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.; Division of Virology and Immunology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Source: The Journal of experimental medicine [J Exp Med] 2026 Nov 02; Vol. 223 (11). Date of Electronic Publication: 2026 Oct 05.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, NY : Rockefeller University Press
MeSH Terms: Translational Research, Biomedical*/methods , Disease Models, Animal* , Microbiota*, Animals ; Mice ; Humans ; Models, Animal
Abstract: Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. Several streams of evidence now indicate that (re)colonizing laboratory mice with a naturally evolved microbiota more faithfully recapitulates key features of the human physiological response. Here, we outline where natural microbiota-based models can improve the investigation of human disease, and how findings in such models bear on several aspects of translational biomedical research.
(© 2026 Gößwein et al.)
Grant Information: DFG SFB 1160 Deutsche Forschungsgemeinschaft; DFG SFB 1755 Deutsche Forschungsgemeinschaft; TRR 359 Deutsche Forschungsgemeinschaft; TRR 417 Deutsche Forschungsgemeinschaft; LEO Foundation; NNF22OC0081244 Novo Nordisk Foundation; CF23-0872 Carlsberg Foundation
Entry Date(s): Date Created: 20261005 Date Completed: 20261005 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1084/jem.20261517
PMID: 42831859
Database: MEDLINE
FullText Text:
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  Data: Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic.
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  Data: <searchLink fieldCode="AU" term="%22Gößwein+M%22">Gößwein M</searchLink>; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Ulmert+I%22">Ulmert I</searchLink>; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rosshart+SP%22">Rosshart SP</searchLink>; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Coquet+JM%22">Coquet JM</searchLink>; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.; Division of Virology and Immunology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2026 Nov 02; Vol. 223 (11). <i>Date of Electronic Publication: </i>2026 Oct 05.
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  Data: Journal Article; Review
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: New York, NY : Rockefeller University Press
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  Data: <searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical%22">Translational Research, Biomedical*</searchLink>/<searchLink fieldCode="MM" term="%22Translational+Research%2C+Biomedical+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal*</searchLink> <br /><searchLink fieldCode="MM" term="%22Microbiota%22">Microbiota*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Models%2C+Animal%22">Models, Animal</searchLink>
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  Label: Abstract
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  Data: Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. Several streams of evidence now indicate that (re)colonizing laboratory mice with a naturally evolved microbiota more faithfully recapitulates key features of the human physiological response. Here, we outline where natural microbiota-based models can improve the investigation of human disease, and how findings in such models bear on several aspects of translational biomedical research.<br /> (© 2026 Gößwein et al.)
– Name: GrantInfo
  Label: Grant Information
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  Data: DFG SFB 1160 Deutsche Forschungsgemeinschaft; DFG SFB 1755 Deutsche Forschungsgemeinschaft; TRR 359 Deutsche Forschungsgemeinschaft; TRR 417 Deutsche Forschungsgemeinschaft; LEO Foundation; NNF22OC0081244 Novo Nordisk Foundation; CF23-0872 Carlsberg Foundation
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  Data: <i>Date Created: </i>20261005 <i>Date Completed: </i>20261005 <i>Latest Revision: </i>20261008
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  Data: 10.1084/jem.20261517
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42831859
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        Text: English
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        Type: general
      – SubjectFull: Mice
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              Text: 2026 Nov 02
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