Academic Journal
Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic.
| Τίτλος: | Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic. |
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| Συγγραφείς: | Gößwein M; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Ulmert I; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Rosshart SP; Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Coquet JM; LEO Foundation, Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.; Division of Virology and Immunology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. |
| Πηγή: | The Journal of experimental medicine [J Exp Med] 2026 Nov 02; Vol. 223 (11). Date of Electronic Publication: 2026 Oct 05. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Rockefeller University Press |
| Ιατρικοί όροι (MeSH): | Translational Research, Biomedical*/methods , Disease Models, Animal* , Microbiota*, Animals ; Mice ; Humans ; Models, Animal |
| Περίληψη: | Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. Several streams of evidence now indicate that (re)colonizing laboratory mice with a naturally evolved microbiota more faithfully recapitulates key features of the human physiological response. Here, we outline where natural microbiota-based models can improve the investigation of human disease, and how findings in such models bear on several aspects of translational biomedical research. (© 2026 Gößwein et al.) |
| Grant Information: | DFG SFB 1160 Deutsche Forschungsgemeinschaft; DFG SFB 1755 Deutsche Forschungsgemeinschaft; TRR 359 Deutsche Forschungsgemeinschaft; TRR 417 Deutsche Forschungsgemeinschaft; LEO Foundation; NNF22OC0081244 Novo Nordisk Foundation; CF23-0872 Carlsberg Foundation |
| Entry Date(s): | Date Created: 20261005 Date Completed: 20261005 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1084/jem.20261517 |
| PMID: | 42831859 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1540-9538 |
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| DOI: | 10.1084/jem.20261517 |