Academic Journal
A Mendelian randomization study reveals TNF-β as a potential protective factor against sarcopenia.
| Τίτλος: | A Mendelian randomization study reveals TNF-β as a potential protective factor against sarcopenia. |
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| Συγγραφείς: | Mei Z; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Wan Y; Department of Stomatology, No. 903 Hospital of PLA, Hangzhou, China., Mao X; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Qi W; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Zhou G; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Chen M; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Li X; Department of Orthopaedics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.; Shanghai University of Traditional Chinese Medicine, Shanghai, China., Pan H; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China., Wang D; Department of Orthopaedics, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. |
| Πηγή: | Medicine [Medicine (Baltimore)] 2026 Oct 02; Vol. 105 (40), pp. e50951. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| Ιατρικοί όροι (MeSH): | Sarcopenia*/genetics , Sarcopenia*/blood , Lymphotoxin-alpha*/genetics , Lymphotoxin-alpha*/blood , Mendelian Randomization Analysis*, Inflammation/genetics ; Hand Strength/physiology ; Humans ; Protective Factors |
| Περίληψη: | Sarcopenia, defined by the loss of muscle mass and strength, significantly impacts the elderly and is linked to chronic inflammation. The exact causal relationship between circulating inflammatory factors and sarcopenia is not yet clear. We employed a 2-sample Mendelian randomization analysis using 91 circulating inflammatory factors as exposures and 4 sarcopenia traits as outcomes to explore potential causality. Our analysis confirmed a significant causal association between circulating inflammatory factors and sarcopenia. Specifically, tumor necrosis factor-beta was significantly associated with all sarcopenia traits (appendicular lean mass: P < .001, odds ratio [OR] = 1.023; left grip strength: P < .001, OR = 1.010; right grip strength: P = .001, OR = 1.008; walking pace: P = .017, OR = 1.004), supported by Bonferroni correction and multiple sensitivity analyses. Tumor necrosis factor-beta has emerged as a critical protective factor for sarcopenia, suggesting that targeting its levels may influence treatment approaches. This study emphasized the role of inflammatory pathways in sarcopenia and demonstrated the utility of Mendelian randomization in identifying these associations. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, LLC.) |
| Competing Interests: | The authors have no conflicts of interest to declare. |
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| Grant Information: | LBY24H290004 Zhejiang Provincial Natural Science Foundation of China under Grant; LQN25H270019 Zhejiang Provincial Natural Science Foundation of China under Grant; 2024-XK-57 Key Discipline of Traditional Chinese Medicine in Zhejiang Province; 2025HZZD16 The Construction Fund of Key Medical Discipline of Hangzhou |
| Contributed Indexing: | Keywords: Mendelian randomization; TNF-β; inflammatory factors; sarcopenia |
| Substance Nomenclature: | 0 (Lymphotoxin-alpha) |
| Entry Date(s): | Date Created: 20261002 Date Completed: 20261002 Latest Revision: 20261005 |
| Update Code: | 20261005 |
| PubMed Central ID: | PMC13632991 |
| DOI: | 10.1097/MD.0000000000050951 |
| PMID: | 42826314 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1536-5964 |
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| DOI: | 10.1097/MD.0000000000050951 |