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Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage.

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Τίτλος: Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage.
Συγγραφείς: Fan X; Department of Clinical Medicine, School of Medicine, Chongqing University, Chongqing, China.; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Lei Y; Department of Health Management and Data Intelligence, Emlyon Business School and école des Mines de Saint-étienne, Lyon, France., Deng Y; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Xiang Y; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Sun C; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Yu X; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Zhang J; Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li C; Medical Imaging Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China., Chen P; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.
Πηγή: Frontiers in neurology [Front Neurol] 2026 Sep 16; Vol. 17, pp. 1915567. Date of Electronic Publication: 2026 Sep 16 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-2295 (Electronic) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: MEDLINE
Imprint Name(s): Original Publication: [Lausanne : Frontiers Research Foundation, 2010]-
Ιατρικοί όροι (MeSH): Cerebral Hemorrhage*/physiopathology , Cerebral Hemorrhage*/complications , Cerebral Hemorrhage*/diagnostic imaging , Executive Function*/physiology , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/diagnostic imaging , Default Mode Network*/physiopathology , Default Mode Network*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Connectome*, Humans ; Male ; Magnetic Resonance Imaging ; Female ; Aged ; Middle Aged
Περίληψη: Objective: This study investigated the macroscopic neural mechanisms of cognitive impairment after Deep Nuclei Intracerebral Hemorrhage (DNICH) from the dimensions of brain activity and brain networks, and further identified characteristic fingerprints of cognitive representation.
Method: Patients with cognitive impairment after DNICH and healthy controls (HC) were prospectively and consecutively enrolled. Resting-state fMRI (rs-fMRI) data and the cognitive scale Mini-Mental State Examination (MMSE) were collected. Spontaneous brain activity measured by fractional Amplitude of Low-Frequency Fluctuations (fALFF) was used to identify hub brain regions of cognitive representation, which were then used as Regions of Interest (ROI) for Functional Connectivity (FC) analysis, in order to investigate the potential mechanisms after DNICH cognitive impairment and identify characteristic fingerprints for distinguishing patients with dementia (dementia was defined as MMSE ≤ 17).
Result: This study enrolled 139 patients with DNICH and 100 HC. There were no significant differences in baseline characteristics including age, gender, years of education, height, and weight between the two groups. Hematomas were predominantly located in the bilateral basal ganglia, more commonly on the left side, with varying degrees of thalamic and white matter involvement. Whole-brain zfALFF analysis showed that MMSE scores were significantly correlated with zfALFF values in brain regions including right dorsolateral prefrontal cortex (R-DLPFC) and posterior cingulate cortex (PCC), with R-DLPFC positively correlated and PCC negatively correlated with cognition (AlphaSim correction, p < 0.01; cluster size >19). In addition, FC within the executive control network (ECN) and default mode network (DMN) was abnormally altered in patients with cognitive impairment and was closely associated with cognitive function (r = -0.29-0.51). FC fingerprints demonstrated stable predictive ability for dementia status (AUC = 0.70-0.73).
Conclusion: Abnormal coordination of intra-network and inter-network FC of ECN and DMN may represent a shared neural mechanism of cognitive impairment after DNICH. Modulating FC between these hub brain regions (R-DLPFC and PCC) may provide new therapeutic strategies for cognitive recovery after DNICH.
(Copyright © 2026 Fan, Lei, Deng, Xiang, Sun, Yu, Zhang, Li and Chen.)
Competing Interests: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Contributed Indexing: Keywords: cognitive impairment; deep nuclei intracerebral hemorrhage; default mode network; executive control network; functional connectivity; spontaneous brain activity
Entry Date(s): Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001
Update Code: 20261001
PubMed Central ID: PMC13623672
DOI: 10.3389/fneur.2026.1915567
PMID: 42818636
Βάση Δεδομένων: MEDLINE
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  Data: Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fan+X%22&quot;&gt;Fan X&lt;/searchLink&gt;; Department of Clinical Medicine, School of Medicine, Chongqing University, Chongqing, China.; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Lei+Y%22&quot;&gt;Lei Y&lt;/searchLink&gt;; Department of Health Management and Data Intelligence, Emlyon Business School and &#233;cole des Mines de Saint-&#233;tienne, Lyon, France.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Deng+Y%22&quot;&gt;Deng Y&lt;/searchLink&gt;; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Xiang+Y%22&quot;&gt;Xiang Y&lt;/searchLink&gt;; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sun+C%22&quot;&gt;Sun C&lt;/searchLink&gt;; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Yu+X%22&quot;&gt;Yu X&lt;/searchLink&gt;; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhang+J%22&quot;&gt;Zhang J&lt;/searchLink&gt;; Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Li+C%22&quot;&gt;Li C&lt;/searchLink&gt;; Medical Imaging Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Chen+P%22&quot;&gt;Chen P&lt;/searchLink&gt;; Chongqing Key Laboratory of Emergency Medicine, Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101546899%22&quot;&gt;Frontiers in neurology&lt;/searchLink&gt; [Front Neurol] 2026 Sep 16; Vol. 17, pp. 1915567. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Sep 16 (&lt;i&gt;Print Publication: &lt;/i&gt;2026).
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study investigated the macroscopic neural mechanisms of cognitive impairment after Deep Nuclei Intracerebral Hemorrhage (DNICH) from the dimensions of brain activity and brain networks, and further identified characteristic fingerprints of cognitive representation.&lt;br /&gt;Method: Patients with cognitive impairment after DNICH and healthy controls (HC) were prospectively and consecutively enrolled. Resting-state fMRI (rs-fMRI) data and the cognitive scale Mini-Mental State Examination (MMSE) were collected. Spontaneous brain activity measured by fractional Amplitude of Low-Frequency Fluctuations (fALFF) was used to identify hub brain regions of cognitive representation, which were then used as Regions of Interest (ROI) for Functional Connectivity (FC) analysis, in order to investigate the potential mechanisms after DNICH cognitive impairment and identify characteristic fingerprints for distinguishing patients with dementia (dementia was defined as MMSE ≤ 17).&lt;br /&gt;Result: This study enrolled 139 patients with DNICH and 100 HC. There were no significant differences in baseline characteristics including age, gender, years of education, height, and weight between the two groups. Hematomas were predominantly located in the bilateral basal ganglia, more commonly on the left side, with varying degrees of thalamic and white matter involvement. Whole-brain zfALFF analysis showed that MMSE scores were significantly correlated with zfALFF values in brain regions including right dorsolateral prefrontal cortex (R-DLPFC) and posterior cingulate cortex (PCC), with R-DLPFC positively correlated and PCC negatively correlated with cognition (AlphaSim correction, p &amp;lt; 0.01; cluster size &gt;19). In addition, FC within the executive control network (ECN) and default mode network (DMN) was abnormally altered in patients with cognitive impairment and was closely associated with cognitive function (r = -0.29-0.51). FC fingerprints demonstrated stable predictive ability for dementia status (AUC = 0.70-0.73).&lt;br /&gt;Conclusion: Abnormal coordination of intra-network and inter-network FC of ECN and DMN may represent a shared neural mechanism of cognitive impairment after DNICH. Modulating FC between these hub brain regions (R-DLPFC and PCC) may provide new therapeutic strategies for cognitive recovery after DNICH.&lt;br /&gt; (Copyright &#169; 2026 Fan, Lei, Deng, Xiang, Sun, Yu, Zhang, Li and Chen.)
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  Data: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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  Label: Contributed Indexing
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;cognitive impairment; deep nuclei intracerebral hemorrhage; default mode network; executive control network; functional connectivity; spontaneous brain activity
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        Text: English
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Magnetic Resonance Imaging
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      – SubjectFull: Cerebral Hemorrhage physiopathology
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      – TitleFull: Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage.
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