Academic Journal
Causal Associations Between Plasma Metabolites and Stroke Risk Identified by Mendelian Randomization.
| Τίτλος: | Causal Associations Between Plasma Metabolites and Stroke Risk Identified by Mendelian Randomization. |
|---|---|
| Συγγραφείς: | Ding L; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China., Li Z; Medical Department, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, China., Deng F; School of Acupuncture and Tuina, School of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, China., Fan B; Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China., Wu Y; College of Physical Education and Public Health, Guangzhou University of Chinese Medicine, Guangzhou, China., Zhang G; Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; School of Medical Imaging, Guizhou Medical University, Guiyang, China., Zeng J; Department of Rehabilitation, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Lu L; Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. |
| Πηγή: | IUBMB life [IUBMB Life] 2026 Oct; Vol. 78 (10), pp. e70124. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis Country of Publication: England NLM ID: 100888706 Publication Model: Print Cited Medium: Internet ISSN: 1521-6551 (Electronic) Linking ISSN: 15216543 NLM ISO Abbreviation: IUBMB Life Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London ; Philadelphia, PA : Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis, c1999- |
| Ιατρικοί όροι (MeSH): | Mendelian Randomization Analysis*/methods , Stroke*/blood , Stroke*/genetics , Stroke*/epidemiology , Stroke*/pathology , Biomarkers*/blood, Humans ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Risk Factors ; Genetic Predisposition to Disease ; Female ; Male |
| Περίληψη: | Stroke is a leading cause of global mortality and morbidity, yet its underlying metabolic mechanisms remain largely undefined. Elucidating the causal role of blood metabolites in stroke pathogenesis is crucial for developing effective interventions. This study employed a two-sample Mendelian randomization (MR) framework to investigate the causal relationships between 1400 plasma metabolites and the risk of stroke and its subtypes. We integrated genome-wide association study (GWAS) data on metabolites from 3441 to 8299 European-ancestry individuals in the Canadian Longitudinal Study on Aging (CLSA) with European-ancestry stroke GWAS data from the MEGASTROKE consortium. IVW associations were interpreted together with Benjamini-Hochberg false-discovery-rate (FDR) correction, sensitivity analyses, and mRnd power estimates. The IVW screening analysis identified 235 nominal associations (P (© 2026 International Union of Biochemistry and Molecular Biology.) |
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| Grant Information: | GZY2025ZJ18 the Peak-Shaping Project under Guangzhou University of Chinese Medicine's Action Plan for Double First-Class and High-Level Disciplinary Development; A1-2601-26-415-109Z67 the Project of First-Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine; A1-2601-24-415-109Z76 the Project of First-Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine; E2-6399-264-109-001 the Project of First-Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine; E4-6401-252-109-002 the Project of First-Class Universities and High-level Dual Discipline for Guangzhou University of Chinese Medicine; 2025KCXTD011 the Guangdong Provincial Higher Education Innovation Team Project; C2501027 the Shenzhen Medical Research Fund; 2024B3006 the Zhongshan TCM Heritage and Innovation Research Program |
| Contributed Indexing: | Keywords: Mendelian randomization analysis; genetic association; metabolic pathway; stroke risk |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| DOI: | 10.1002/iub.70124 |
| PMID: | 42817703 |
| Βάση Δεδομένων: | MEDLINE |
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