Academic Journal
A single-dose topical therapy cures scabies in a human-relevant porcine model.
| Τίτλος: | A single-dose topical therapy cures scabies in a human-relevant porcine model. |
|---|---|
| Συγγραφείς: | Fernando DD; Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia.; School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia.; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia., Taylor S; Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia.; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia., Samarawickrama GR; Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia.; School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia., Nammunige NA; Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia.; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.; School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4067, Australia., Hartel G; Statistics Unit, QIMR Berghofer, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia., Bowles V; Melbourne Veterinary School, University of Melbourne, 30 Flemington Rd, Parkville, VIC 3052, Australia., Fischer K; Infection and Inflammation Program, QIMR Berghofer, 300 Herston Road, Herston, QLD 4006, Australia.; School of Veterinary Science, University of Queensland, Cnr Main Drive and Outer Ring Road, Gatton, QLD 4343, Australia.; School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia. |
| Πηγή: | Science translational medicine [Sci Transl Med] 2026 Sep 30; Vol. 18 (869), pp. eaeg5917. Date of Electronic Publication: 2026 Sep 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Association for the Advancement of Science |
| Ιατρικοί όροι (MeSH): | Scabies*/drug therapy , Scabies*/parasitology, Ivermectin/therapeutic use ; Ivermectin/administration & dosage ; Skin/parasitology ; Pruritus/drug therapy ; Animals ; Humans ; Administration, Topical ; Disease Models, Animal ; Swine ; Female |
| Περίληψη: | Scabies affects ∼400 million people annually, yet current therapies lack ovicidal activity, require repeat dosing, and are increasingly compromised by treatment failure and resistance. The absence of a single-application therapy capable of eliminating both motile mites and eggs represents one important limitation to effective disease control. We developed a mechanism-informed topical therapy combining abametapir, a metalloprotease inhibitor with ovicidal activity, and flavesone, a β-triketone with rapid miticidal effects, designed to target multiple parasite life stages through distinct, non-neurotoxic mechanisms. Using a porcine model that closely recapitulates human scabies, we assessed efficacy, pruritus reduction, and pharmacologic exposure after topical administration. In severe scabies, a single 4-hour treatment eradicated all live mites and eggs and reduced pruritus, outperforming a standard two-dose oral ivermectin regimen. Skin pharmacokinetics demonstrated rapid attainment of concentrations with exposure profiles, supporting single-dose efficacy despite shorter systemic half-lives than ivermectin. Together, this promising therapeutic combination may offer a simplified and potentially resistance-resilient approach to scabies management. |
| Substance Nomenclature: | 70288-86-7 (Ivermectin) |
| Entry Date(s): | Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20260930 |
| Update Code: | 20261001 |
| DOI: | 10.1126/scitranslmed.aeg5917 |
| PMID: | 42814804 |
| Βάση Δεδομένων: | MEDLINE |
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