Academic Journal
Longitudinal Changes in Hippocampal-Default Mode Network Connectivity and Cognition During Electroacupuncture Intervention in Type 2 Diabetes-Associated Cognitive Decline: A Pilot Resting-State fMRI Study.
| Τίτλος: | Longitudinal Changes in Hippocampal-Default Mode Network Connectivity and Cognition During Electroacupuncture Intervention in Type 2 Diabetes-Associated Cognitive Decline: A Pilot Resting-State fMRI Study. |
|---|---|
| Συγγραφείς: | Yao L; Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Li MY; Institute of Acupuncture and Massage, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Liu YZ; Acupuncture and Tuina Center, The Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Cao JZ; College of nursing, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Lian Z; College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Zhu HN; College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Huang HP; College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Zhong Z; College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China., Wang HF; College of Acupuncture and Massage, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China. |
| Πηγή: | Journal of integrative neuroscience [J Integr Neurosci] 2026 Sep 21; Vol. 25 (9), pp. 52929. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IMR Press Country of Publication: Singapore NLM ID: 101156357 Publication Model: Print Cited Medium: Internet ISSN: 0219-6352 (Print) Linking ISSN: 02196352 NLM ISO Abbreviation: J Integr Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021-: Singapore : IMR Press Original Publication: London : Imperial College Press, c2002- |
| Ιατρικοί όροι (MeSH): | Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/physiopathology , Diabetes Mellitus, Type 2*/diagnostic imaging , Hippocampus*/diagnostic imaging , Hippocampus*/physiopathology , Default Mode Network*/diagnostic imaging , Default Mode Network*/physiopathology , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/diagnostic imaging , Cognitive Dysfunction*/therapy , Nerve Net*/diagnostic imaging , Nerve Net*/physiopathology , Electroacupuncture* , Connectome*, Humans ; Pilot Projects ; Magnetic Resonance Imaging ; Female ; Male ; Longitudinal Studies ; Middle Aged ; Aged ; Cognitive Enhancement |
| Περίληψη: | Background: Type 2 diabetes mellitus-associated cognitive dysfunction (T2DACD) is strongly linked to disruption of cognition-supporting brain networks. Electroacupuncture (EA) has increasingly been examined as a nonpharmacological intervention targeting cognitive impairment; however, the longitudinal neurobiological patterns accompanying EA in T2DACD have not been fully characterized. In this exploratory pilot study, we evaluated alterations in resting-state functional connectivity (RSFC) across hippocampal subregions and default mode network (DMN) nodes in individuals with T2DACD. Methods: For this exploratory, open-label, non-randomized, uncontrolled pilot investigation, we enrolled 20 individuals with T2DACD and 26 healthy controls (HCs). Longitudinal analyses included 15 participants who had usable post-treatment data. T2DACD was defined according to clinical type 2 diabetes mellitus criteria, and a Montreal Cognitive Assessment (MoCA) score <26. Patients underwent an 8-week Adjust Zang-fu and Arouse Spirit electroacupuncture (AZASE) intervention. Cognitive, emotional, metabolic, and seed-based resting-state functional magnetic resonance imaging (rs-fMRI) outcomes were evaluated. Clinical longitudinal analyses were carried out according to protocol, whereas imaging analyses were limited to participants with usable scans after treatment. Results: At baseline, individuals with T2DACD showed lower MoCA scores than HCs and had poorer executive and working-memory outcomes. Among the 15 participants with complete longitudinal neuroimaging data, MoCA scores increased from 23.27 ± 1.71 to 26.07 ± 1.53 over the intervention period. Within-group alterations were observed for Flanker-conflict reaction time and accuracy, Stroop-conflict reaction time, 1-back reaction time, Self-Rating Anxiety Scale score, and Hamilton Depression Rating Scale score. Omnibus group analyses detected significant effects for the left anterior hippocampus-left angular gyrus connection and the left posterior hippocampus-right middle occipital gyrus connection. Post-treatment scans demonstrated reduced RSFC in several hippocampal-DMN and intra-DMN connections. The association between change in left anterior hippocampus-left angular gyrus RSFC and change in Stroop-conflict performance was no longer statistically significant after Bonferroni correction. For neuroimaging outcomes, cluster-level family-wise error (FWE) correction (p < 0.05) was applied to control for multiple comparisons; clinical outcomes are reported descriptively as hypothesis-generating findings. Conclusions: In this exploratory pilot study, we identified preliminary alterations in cognitive outcomes and hippocampal-DMN connections over an 8-week EA intervention in individuals with T2DACD. In view of the small sample size and the open-label, non-randomized, uncontrolled design, the findings should be interpreted as hypothesis-generating observations rather than definitive evidence of a specific causal treatment effect. Larger controlled studies will be needed to determine whether the observed neural and behavioral alterations are reproducible and clinically meaningful in practice. Clinical Trial Registration: No: ChiCTR2000040268, https://www.chictr.org.cn/hvshowproject.html?id=76145&v=1.3. (Copyright: © 2026 The Author(s). Published by IMR Press.) |
| Competing Interests: | The authors declare no conflicts of interest. |
| Grant Information: | 82074548 National Natural Science Foundation of China; YDZJ202401680ZYTS Natural Science Foundation of Jilin Province (Free exploration of general projects) |
| Contributed Indexing: | Keywords: cognitive dysfunction; default mode network; diabetes mellitus, type 2; electroacupuncture; hippocampus; magnetic resonance imaging |
| Entry Date(s): | Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20260930 |
| Update Code: | 20260930 |
| DOI: | 10.31083/JIN52929 |
| PMID: | 42811891 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!