Academic Journal
Default mode network functional connectivity is associated with intention interference in healthy aging.
| Τίτλος: | Default mode network functional connectivity is associated with intention interference in healthy aging. |
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| Συγγραφείς: | Liang TJ; Department of Psychology, National Chung Cheng University, No. 168, University Rd., Minhsiung Township, Chiayi County 621, Chiayi County, Taiwan.; Department of Psychiatry, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan., Huang SM; Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan., Tu MC; Department of Neurology, China Medical University Hospital, Taichung, Taiwan., Kuo LW; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan.; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan., Yang JJ; Department of Medical Imaging, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan., Hsu YH; Department of Psychology, National Chung Cheng University, No. 168, University Rd., Minhsiung Township, Chiayi County 621, Chiayi County, Taiwan. PsyYHH@ccu.edu.tw.; Institute of Aging, Work and Wellbeing, National Chung Cheng University, Chiayi County, Taiwan. PsyYHH@ccu.edu.tw. |
| Πηγή: | Brain imaging and behavior [Brain Imaging Behav] 2026 Sep 29; Vol. 20 (5). Date of Electronic Publication: 2026 Sep 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Secaucus, NJ : Springer |
| Ιατρικοί όροι (MeSH): | Default Mode Network*/physiology , Default Mode Network*/diagnostic imaging , Brain*/physiology , Brain*/diagnostic imaging , Healthy Aging*/physiology , Healthy Aging*/psychology , Intention* , Memory, Episodic*, Reaction Time/physiology ; Neural Pathways/physiology ; Neural Pathways/diagnostic imaging ; Nerve Net/physiology ; Humans ; Magnetic Resonance Imaging ; Female ; Male ; Brain Mapping ; Middle Aged ; Aged |
| Περίληψη: | Prospective memory (PM), the ability to fulfil an intended action, is important in daily life. However, completed intentions can interfere with subsequent behaviors, known as the aftereffect. The neural basis of this phenomenon remains unclear, particularly from a network perspective. Based on cognitive theories, the present study aimed to examine the underlying neural mechanisms, focusing on the default mode network (DMN) and the frontoparietal network (FPN) to resolve previously inconsistent findings. Thirty-six middle-to-older adults completed a memory-for-intention task, with outdated cues assessing aftereffects through commission errors and prolonged reaction time. Resting-state functional magnetic resonance imaging data were used to calculate functional connectivity (FC) between regions of interest within the DMN and the FPN. The results showed that FC between the left superior frontal gyrus and right middle temporal pole was associated with the late aftereffect reflected by prolonged reaction time. No significant associations were found within the FPN. The findings highlight the role of intrinsic connectivity in the DMN, suggesting that task disengagement and self-referential processing may contribute to the unintended activation of completed intentions, supporting the spontaneous retrieval account in the dual mechanism theory. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the institutional Research Ethics Committee in Taichung Tzu Chi Hospital (No. REC106-48, version 6.0, January 18, 2022). Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests. |
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| Grant Information: | NSTC 113-2410-H-194-088 National Science and Technology Council; MOST 109-2410-H-194 -053-MY2 Ministry of Science and Technology, Taiwan |
| Contributed Indexing: | Keywords: Aftereffect; Default Mode Network; Functional connectivity; Intention Interference; Prospective memory |
| Entry Date(s): | Date Created: 20260929 Date Completed: 20260929 Latest Revision: 20260929 |
| Update Code: | 20260930 |
| DOI: | 10.1007/s11682-026-01205-y |
| PMID: | 42809038 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1931-7565 |
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| DOI: | 10.1007/s11682-026-01205-y |