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Radiation therapy and overall survival in male breast cancer: a multicenter analysis of 302 patients.

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Τίτλος: Radiation therapy and overall survival in male breast cancer: a multicenter analysis of 302 patients.
Συγγραφείς: Colciago RR; Medicine and Surgery Department, University of Milan Bicocca, 20126, Milan, Italy. Riccardoraycolciago@gmail.com., Franco P; Department of Translational Medicine (DIMET), University of Eastern Piedmont, Novara, Italy.; Department of Radiation Oncology, 'Maggiore Della Carità' University Hospital, 28100, Novara, Italy., Giandini C; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, 20133, Milan, Italy., Carnevale MG; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, 20133, Milan, Italy., Di Cosimo S; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy., Minicozzi P; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy., Manitto R; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy., Ferrara E; Department of Radiation Oncology, 'Maggiore Della Carità' University Hospital, 28100, Novara, Italy., Fozza A; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Coco A; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Spoto R; Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, 20089, RozzanoMilan, Italy., Dominici L; Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, 20089, RozzanoMilan, Italy., Marino L; Servizio Di Radioterapia, Humanitas Istituto Clinico Catanese, Misterbianco, CT, Italy., Lucidi S; Radiation Oncology, APSS, Trento, Italy., De Rose F; Radiation Oncology, APSS, Trento, Italy., Bonzano E; Radiation Oncology Department, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy., Prisco A; Department of Radiation Oncology, University Hospital of Udine, ASUFC, 33100, Udine, Italy., Meduri B; Protontherapy Department, Azienda Provinciale Per I Servizi Sanitari, Trento, Italy., Bertini N; Radiation Oncology & Breast Unit, Florence University Hospital, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Meattini I; Radiation Oncology & Breast Unit, Florence University Hospital, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Florence, Italy.; Department of Radiation Oncology (MAASTRO), GROW Research Institute for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands., Verderio P; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy., De Santis MC; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, 20133, Milan, Italy.
Πηγή: La Radiologia medica [Radiol Med] 2026 Oct; Vol. 131 (10), pp. 1935-1948. Date of Electronic Publication: 2026 Sep 28.
Τύπος έκδοσης: Journal Article; Multicenter Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Milan Country of Publication: Italy NLM ID: 0177625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1826-6983 (Electronic) Linking ISSN: 00338362 NLM ISO Abbreviation: Radiol Med Subsets: MEDLINE
Imprint Name(s): Publication: Milan : Springer Milan
Original Publication: Torino [etc.] Minerva medica.
Ιατρικοί όροι (MeSH): Breast Neoplasms, Male*/radiotherapy , Breast Neoplasms, Male*/mortality , Breast Neoplasms, Male*/pathology, Italy/epidemiology ; Humans ; Male ; Retrospective Studies ; Radiotherapy, Adjuvant ; Aged ; Neoplasm Staging ; Middle Aged ; Disease-Free Survival ; Mastectomy ; Prognosis ; Survival Rate ; Aged, 80 and over ; Chemotherapy, Adjuvant
Περίληψη: Aim: This multicenter study aimed to assess the efficacy and the prognostic role of adjuvant radiation therapy and other factors in a cohort of male breast cancer patients (MaBC) treated in 10 Italian centers within the Clinical Oncology Breast Cancer Group.
Methods: This retrospective study included patients diagnosed with MaBC between 2005 and 2023. Demographic, clinical, tumor, and treatment data were retrieved from medical records. Information on treatment-related acute and late adverse events was also collected. Disease-free survival (DFS) was calculated from surgery to recurrence or last follow-up visit, overall survival (OS) from diagnosis to death or last follow-up visit.
Results: Overall, 302 patients were included (median age 69). Most were diagnosed with stage I-IIIa (75%; vs 25% stage IIIb-IV), invasive ductal carcinoma (88%) and luminal-like tumors (88%). Nearly all patients underwent mastectomy (96%), 31% received adjuvant chemotherapy, 83% endocrine therapy (mainly tamoxifen), and 33% radiation therapy. At a median follow-up of 79 months, DFS and OS were significantly associated, among others, with stage (p < 0.05). In stage IIIb-IV patients, omission of radiation therapy was associated with higher recurrence risk (hazard ratio, HR = 18.8, p < 0.001) and worse OS (HR = 6.45, p < 0.001). Acute radiation therapy-related adverse events occurred in 28% of patients, mostly graded 1-2, but no severe late toxicity was observed.
Conclusions: This large retrospective cohort study showed that MaBC patients treated with multi-modality therapies achieved favorable outcomes. Specifically, radiation therapy significantly improved survival in advanced stages with low incidence of late adverse events further supporting its role in daily clinical practice.
(© 2026. Italian Society of Medical Radiology.)
Competing Interests: Declarations. Competing interest: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: All procedures adhered to institutional and national ethical standards, in accordance with the 1964 Helsinki Declaration and its subsequent amendments or comparable ethical standards. The study was approved by the ethical committee (Approval Number INT 171/22). Informed consent: Informed consent was obtained from all individual participants involved in the study.
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Contributed Indexing: Keywords: Long-term results; Male breast cancer; Overall survival; Radiation therapy
Entry Date(s): Date Created: 20260928 Date Completed: 20261014 Latest Revision: 20261016
Update Code: 20261016
DOI: 10.1007/s11547-026-02276-z
PMID: 42804144
Βάση Δεδομένων: MEDLINE
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  Data: Radiation therapy and overall survival in male breast cancer: a multicenter analysis of 302 patients.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Colciago+RR%22&quot;&gt;Colciago RR&lt;/searchLink&gt;; Medicine and Surgery Department, University of Milan Bicocca, 20126, Milan, Italy. Riccardoraycolciago@gmail.com.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Franco+P%22&quot;&gt;Franco P&lt;/searchLink&gt;; Department of Translational Medicine (DIMET), University of Eastern Piedmont, Novara, Italy.; Department of Radiation Oncology, &#39;Maggiore Della Carit&#224;&#39; University Hospital, 28100, Novara, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Giandini+C%22&quot;&gt;Giandini C&lt;/searchLink&gt;; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, 20133, Milan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Carnevale+MG%22&quot;&gt;Carnevale MG&lt;/searchLink&gt;; Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, 20133, Milan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Di+Cosimo+S%22&quot;&gt;Di Cosimo S&lt;/searchLink&gt;; Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Minicozzi+P%22&quot;&gt;Minicozzi P&lt;/searchLink&gt;; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Manitto+R%22&quot;&gt;Manitto R&lt;/searchLink&gt;; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale Dei Tumori, 20133, Milan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ferrara+E%22&quot;&gt;Ferrara E&lt;/searchLink&gt;; Department of Radiation Oncology, &#39;Maggiore Della Carit&#224;&#39; University Hospital, 28100, Novara, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Fozza+A%22&quot;&gt;Fozza A&lt;/searchLink&gt;; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Coco+A%22&quot;&gt;Coco A&lt;/searchLink&gt;; Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Spoto+R%22&quot;&gt;Spoto R&lt;/searchLink&gt;; Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, 20089, RozzanoMilan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Dominici+L%22&quot;&gt;Dominici L&lt;/searchLink&gt;; Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, 20089, RozzanoMilan, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Marino+L%22&quot;&gt;Marino L&lt;/searchLink&gt;; Servizio Di Radioterapia, Humanitas Istituto Clinico Catanese, Misterbianco, CT, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Lucidi+S%22&quot;&gt;Lucidi S&lt;/searchLink&gt;; Radiation Oncology, APSS, Trento, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22De+Rose+F%22&quot;&gt;De Rose F&lt;/searchLink&gt;; Radiation Oncology, APSS, Trento, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Bonzano+E%22&quot;&gt;Bonzano E&lt;/searchLink&gt;; Radiation Oncology Department, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Prisco+A%22&quot;&gt;Prisco A&lt;/searchLink&gt;; Department of Radiation Oncology, University Hospital of Udine, ASUFC, 33100, Udine, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Meduri+B%22&quot;&gt;Meduri B&lt;/searchLink&gt;; Protontherapy Department, Azienda Provinciale Per I Servizi Sanitari, Trento, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Bertini+N%22&quot;&gt;Bertini N&lt;/searchLink&gt;; Radiation Oncology &amp; Breast Unit, Florence University Hospital, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Meattini+I%22&quot;&gt;Meattini I&lt;/searchLink&gt;; Radiation Oncology &amp; Breast Unit, Florence University Hospital, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences &#39;M. 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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male%22&quot;&gt;Breast Neoplasms, Male*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male+radiotherapy%22&quot;&gt;radiotherapy&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male%22&quot;&gt;Breast Neoplasms, Male*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male+mortality%22&quot;&gt;mortality&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male%22&quot;&gt;Breast Neoplasms, Male*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Breast+Neoplasms%2C+Male+pathology%22&quot;&gt;pathology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Italy%22&quot;&gt;Italy&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Italy+epidemiology%22&quot;&gt;epidemiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Retrospective+Studies%22&quot;&gt;Retrospective Studies&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Radiotherapy%2C+Adjuvant%22&quot;&gt;Radiotherapy, Adjuvant&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%22&quot;&gt;Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Neoplasm+Staging%22&quot;&gt;Neoplasm Staging&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Disease-Free+Survival%22&quot;&gt;Disease-Free Survival&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Mastectomy%22&quot;&gt;Mastectomy&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Prognosis%22&quot;&gt;Prognosis&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Survival+Rate%22&quot;&gt;Survival Rate&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%2C+80+and+over%22&quot;&gt;Aged, 80 and over&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Chemotherapy%2C+Adjuvant%22&quot;&gt;Chemotherapy, Adjuvant&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: This multicenter study aimed to assess the efficacy and the prognostic role of adjuvant radiation therapy and other factors in a cohort of male breast cancer patients (MaBC) treated in 10 Italian centers within the Clinical Oncology Breast Cancer Group.&lt;br /&gt;Methods: This retrospective study included patients diagnosed with MaBC between 2005 and 2023. Demographic, clinical, tumor, and treatment data were retrieved from medical records. Information on treatment-related acute and late adverse events was also collected. Disease-free survival (DFS) was calculated from surgery to recurrence or last follow-up visit, overall survival (OS) from diagnosis to death or last follow-up visit.&lt;br /&gt;Results: Overall, 302 patients were included (median age 69). Most were diagnosed with stage I-IIIa (75%; vs 25% stage IIIb-IV), invasive ductal carcinoma (88%) and luminal-like tumors (88%). Nearly all patients underwent mastectomy (96%), 31% received adjuvant chemotherapy, 83% endocrine therapy (mainly tamoxifen), and 33% radiation therapy. At a median follow-up of 79&#160;months, DFS and OS were significantly associated, among others, with stage (p &amp;lt; 0.05). In stage IIIb-IV patients, omission of radiation therapy was associated with higher recurrence risk (hazard ratio, HR = 18.8, p &amp;lt; 0.001) and worse OS (HR = 6.45, p &amp;lt; 0.001). Acute radiation therapy-related adverse events occurred in 28% of patients, mostly graded 1-2, but no severe late toxicity was observed.&lt;br /&gt;Conclusions: This large retrospective cohort study showed that MaBC patients treated with multi-modality therapies achieved favorable outcomes. Specifically, radiation therapy significantly improved survival in advanced stages with low incidence of late adverse events further supporting its role in daily clinical practice.&lt;br /&gt; (&#169; 2026. Italian Society of Medical Radiology.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Competing interest: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: All procedures adhered to institutional and national ethical standards, in accordance with the 1964 Helsinki Declaration and its subsequent amendments or comparable ethical standards. The study was approved by the ethical committee (Approval Number INT 171/22). Informed consent: Informed consent was obtained from all individual participants involved in the study.
– Name: Ref
  Label: References
  Group: RefInfo
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– Name: SubjectMinor
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  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Long-term results; Male breast cancer; Overall survival; Radiation therapy
– Name: DateEntry
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260928 &lt;i&gt;Date Completed: &lt;/i&gt;20261014 &lt;i&gt;Latest Revision: &lt;/i&gt;20261016
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  Data: 20261016
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  Data: 10.1007/s11547-026-02276-z
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  Data: 42804144
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s11547-026-02276-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1935
    Subjects:
      – SubjectFull: Italy epidemiology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Retrospective Studies
        Type: general
      – SubjectFull: Radiotherapy, Adjuvant
        Type: general
      – SubjectFull: Aged
        Type: general
      – SubjectFull: Neoplasm Staging
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Disease-Free Survival
        Type: general
      – SubjectFull: Mastectomy
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Survival Rate
        Type: general
      – SubjectFull: Aged, 80 and over
        Type: general
      – SubjectFull: Chemotherapy, Adjuvant
        Type: general
      – SubjectFull: Breast Neoplasms, Male radiotherapy
        Type: general
      – SubjectFull: Breast Neoplasms, Male mortality
        Type: general
      – SubjectFull: Breast Neoplasms, Male pathology
        Type: general
    Titles:
      – TitleFull: Radiation therapy and overall survival in male breast cancer: a multicenter analysis of 302 patients.
        Type: main
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          Name:
            NameFull: Manitto R
      – PersonEntity:
          Name:
            NameFull: Ferrara E
      – PersonEntity:
          Name:
            NameFull: Fozza A
      – PersonEntity:
          Name:
            NameFull: Coco A
      – PersonEntity:
          Name:
            NameFull: Spoto R
      – PersonEntity:
          Name:
            NameFull: Dominici L
      – PersonEntity:
          Name:
            NameFull: Marino L
      – PersonEntity:
          Name:
            NameFull: Lucidi S
      – PersonEntity:
          Name:
            NameFull: De Rose F
      – PersonEntity:
          Name:
            NameFull: Bonzano E
      – PersonEntity:
          Name:
            NameFull: Prisco A
      – PersonEntity:
          Name:
            NameFull: Meduri B
      – PersonEntity:
          Name:
            NameFull: Bertini N
      – PersonEntity:
          Name:
            NameFull: Meattini I
      – PersonEntity:
          Name:
            NameFull: Verderio P
      – PersonEntity:
          Name:
            NameFull: De Santis MC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1826-6983
          Numbering:
            – Type: volume
              Value: 131
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: La Radiologia medica
              Type: main
ResultId 1