Academic Journal
Comparison of Remimazolam and Propofol for Anesthesia Management in Liver Cancer Patients Undergoing Percutaneous Radiofrequency Ablation: A Randomized Controlled Trial.
| Τίτλος: | Comparison of Remimazolam and Propofol for Anesthesia Management in Liver Cancer Patients Undergoing Percutaneous Radiofrequency Ablation: A Randomized Controlled Trial. |
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| Συγγραφείς: | Jiang P; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China., Deng M; Department of Surgery Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China., Wang Q; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China., Feng Y; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China., Wang D; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China., Chen X; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China. |
| Πηγή: | Drug design, development and therapy [Drug Des Devel Ther] 2026 Sep 22; Vol. 20, pp. 645319. Date of Electronic Publication: 2026 Sep 22 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Auckland, N.Z.] : Dove Press Limited |
| Ιατρικοί όροι (MeSH): | Propofol*/administration & dosage , Propofol*/therapeutic use , Propofol*/pharmacology , Liver Neoplasms*/surgery , Liver Neoplasms*/drug therapy , Carcinoma, Hepatocellular*/surgery , Radiofrequency Ablation*, Humans ; Female ; Male ; Middle Aged ; Aged ; Benzodiazepines |
| Περίληψη: | Background: Ultrasound-guided percutaneous radiofrequency ablation (PRFA) is an effective treatment for small hepatocellular carcinoma, but anesthesia management in patients with liver cancer and comorbidities remains challenging. This study aimed to compare the anesthetic efficacy and safety of remimazolam combined with remifentanil versus propofol in patients undergoing PRFA. Methods: Eighty-two participants were randomly assigned to receive either propofol (Group P, n = 41) or remimazolam (Group R, n = 41) for anesthesia, both combined with remifentanil for analgesia. The primary outcome was mean arterial pressure (MAP) across seven perioperative time points. Secondary outcomes included heart rate (HR), Cerebral State Index (CSI), oxygen saturation (SpO Results: In the ITT analysis (n = 82), linear mixed-effects models showed a significant group × time interaction for MAP (F[6, 77.139] = 11.913, p < 0.001), with higher MAP in Group R at T Conclusion: Remimazolam with remifentanil provided better hemodynamic stability and respiratory safety than propofol in PRFA for liver cancer (Child-Pugh A/B, without severe comorbidities). The shorter recovery time, though partly confounded by flumazenil, supports remimazolam as a promising alternative. Further studies in higher-risk patients are needed. Clinical Trial Registration: The trial was registered before patient enrolment at http://www.chictr.org.cn (ChiCTR2300078192), and was registered on November 30, 2023. (© 2026 Jiang et al.) |
| Competing Interests: | The authors report no competing interests in this work. |
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| Contributed Indexing: | Keywords: anesthesia management; hemodynamic stability; liver cancer; percutaneous radiofrequency ablation; propofol; remimazolam |
| Substance Nomenclature: | YI7VU623SF (Propofol) 7V4A8U16MB (remimazolam) 12794-10-4 (Benzodiazepines) |
| Entry Date(s): | Date Created: 20260927 Date Completed: 20260927 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| PubMed Central ID: | PMC13615802 |
| DOI: | 10.2147/DDDT.S645319 |
| PMID: | 42801141 |
| Βάση Δεδομένων: | MEDLINE |
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