Editorial & Opinion
Biological aging for the advancement of biogerontology: Between hopes and hypes.
| Τίτλος: | Biological aging for the advancement of biogerontology: Between hopes and hypes. |
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| Συγγραφείς: | Marzetti E; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy. Electronic address: emanuele.marzetti@unicatt.it., Picca A; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy; Department of Medicine and Surgery, LUM University, Casamassima, Italy. |
| Πηγή: | The journal of nutrition, health & aging [J Nutr Health Aging] 2026 Oct; Vol. 30 (10), pp. 100992. Date of Electronic Publication: 2026 Sep 26. |
| Τύπος έκδοσης: | Editorial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co. |
| Ιατρικοί όροι (MeSH): | Aging*/physiology , Geroscience*/trends , Geriatrics*/trends, Biomarkers/blood ; Humans |
| Περίληψη: | Population aging has intensified the search for biological measures that can explain why individuals of the same chronological age differ so markedly in health, function, resilience, and disease burden. Geroscience has provided a powerful framework by linking shared mechanisms of aging to multiple age-related conditions, but translation to clinical practice remains incomplete. Aging clocks and circulating biomarkers have improved biological-age estimation, yet prediction alone does not establish biological meaning or clinical utility. Emerging evidence instead supports a view of aging as a heterogeneous and multidimensional process shaped by organ-specific vulnerability, cumulative stress, multimorbidity, and declining resilience. The field should therefore move beyond single biomarkers and universal aging clocks toward gerodiagnostic approaches that characterize individual aging trajectories and their modifiability. Progress in gerotherapeutics will similarly require closer integration of mechanism, measurement, and intervention. The ultimate goal is not merely to quantify aging, but to identify actionable biological processes whose modification may preserve function, delay multimorbidity, and extend healthspan. (Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest EM reports financial support was provided by Italian Ministry of Health. AP has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Aging; Biomarkers; Geroscience; Healthspan; Intrinsic capacity; Resilience |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20260926 Date Completed: 20261003 Latest Revision: 20261006 |
| Update Code: | 20261007 |
| DOI: | 10.1016/j.jnha.2026.100992 |
| PMID: | 42800282 |
| Βάση Δεδομένων: | MEDLINE |
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