Editorial & Opinion
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Biological aging for the advancement of biogerontology: Between hopes and hypes.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Biological aging for the advancement of biogerontology: Between hopes and hypes.
Συγγραφείς: Marzetti E; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy. Electronic address: emanuele.marzetti@unicatt.it., Picca A; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy; Department of Medicine and Surgery, LUM University, Casamassima, Italy.
Πηγή: The journal of nutrition, health & aging [J Nutr Health Aging] 2026 Oct; Vol. 30 (10), pp. 100992. Date of Electronic Publication: 2026 Sep 26.
Τύπος έκδοσης: Editorial
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE
Imprint Name(s): Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher
Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co.
Ιατρικοί όροι (MeSH): Aging*/physiology , Geroscience*/trends , Geriatrics*/trends, Biomarkers/blood ; Humans
Περίληψη: Population aging has intensified the search for biological measures that can explain why individuals of the same chronological age differ so markedly in health, function, resilience, and disease burden. Geroscience has provided a powerful framework by linking shared mechanisms of aging to multiple age-related conditions, but translation to clinical practice remains incomplete. Aging clocks and circulating biomarkers have improved biological-age estimation, yet prediction alone does not establish biological meaning or clinical utility. Emerging evidence instead supports a view of aging as a heterogeneous and multidimensional process shaped by organ-specific vulnerability, cumulative stress, multimorbidity, and declining resilience. The field should therefore move beyond single biomarkers and universal aging clocks toward gerodiagnostic approaches that characterize individual aging trajectories and their modifiability. Progress in gerotherapeutics will similarly require closer integration of mechanism, measurement, and intervention. The ultimate goal is not merely to quantify aging, but to identify actionable biological processes whose modification may preserve function, delay multimorbidity, and extend healthspan.
(Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Competing Interests: Declaration of competing interest EM reports financial support was provided by Italian Ministry of Health. AP has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Aging; Biomarkers; Geroscience; Healthspan; Intrinsic capacity; Resilience
Substance Nomenclature: 0 (Biomarkers)
Entry Date(s): Date Created: 20260926 Date Completed: 20261003 Latest Revision: 20261006
Update Code: 20261007
DOI: 10.1016/j.jnha.2026.100992
PMID: 42800282
Βάση Δεδομένων: MEDLINE
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4CF78A571CE4BC8809ED&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.jnha.2026.100992?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://dx.doi.org/doi:10.1016/j.jnha.2026.100992
    Name: EDS - Springer Nature Journals (s7799221)
    Category: fullText
    Text: View record at Springer
Header DbId: cmedm
DbLabel: MEDLINE
An: 42800282
AccessLevel: 3
PubType: Editorial & Opinion
PubTypeId: editorialOpinion
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Biological aging for the advancement of biogerontology: Between hopes and hypes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Marzetti+E%22">Marzetti E</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy. Electronic address: emanuele.marzetti@unicatt.it.<br /><searchLink fieldCode="AU" term="%22Picca+A%22">Picca A</searchLink>; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy; Department of Medicine and Surgery, LUM University, Casamassima, Italy.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100893366%22">The journal of nutrition, health & aging</searchLink> [J Nutr Health Aging] 2026 Oct; Vol. 30 (10), pp. 100992. <i>Date of Electronic Publication: </i>2026 Sep 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Editorial
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Masson+SAS+on+behalf+of+SERDI+Publisher%22">Elsevier Masson SAS on behalf of SERDI Publisher </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>100893366 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1760-4788 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2212797707%22">12797707 </searchLink><i>NLM ISO Abbreviation: </i>J Nutr Health Aging <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher<br /><i>Original Publication</i>: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Aging%22">Aging*</searchLink>/<searchLink fieldCode="MM" term="%22Aging+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Geroscience%22">Geroscience*</searchLink>/<searchLink fieldCode="MM" term="%22Geroscience+trends%22">trends</searchLink> <br /><searchLink fieldCode="MM" term="%22Geriatrics%22">Geriatrics*</searchLink>/<searchLink fieldCode="MM" term="%22Geriatrics+trends%22">trends</searchLink><br /><searchLink fieldCode="MH" term="%22Biomarkers%22">Biomarkers</searchLink>/<searchLink fieldCode="MH" term="%22Biomarkers+blood%22">blood</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Population aging has intensified the search for biological measures that can explain why individuals of the same chronological age differ so markedly in health, function, resilience, and disease burden. Geroscience has provided a powerful framework by linking shared mechanisms of aging to multiple age-related conditions, but translation to clinical practice remains incomplete. Aging clocks and circulating biomarkers have improved biological-age estimation, yet prediction alone does not establish biological meaning or clinical utility. Emerging evidence instead supports a view of aging as a heterogeneous and multidimensional process shaped by organ-specific vulnerability, cumulative stress, multimorbidity, and declining resilience. The field should therefore move beyond single biomarkers and universal aging clocks toward gerodiagnostic approaches that characterize individual aging trajectories and their modifiability. Progress in gerotherapeutics will similarly require closer integration of mechanism, measurement, and intervention. The ultimate goal is not merely to quantify aging, but to identify actionable biological processes whose modification may preserve function, delay multimorbidity, and extend healthspan.<br /> (Copyright © 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest EM reports financial support was provided by Italian Ministry of Health. AP has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Aging; Biomarkers; Geroscience; Healthspan; Intrinsic capacity; Resilience
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Biomarkers)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260926 <i>Date Completed: </i>20261003 <i>Latest Revision: </i>20261006
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20261007
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.jnha.2026.100992
– Name: AN
  Label: PMID
  Group: ID
  Data: 42800282
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42800282
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jnha.2026.100992
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 100992
    Subjects:
      – SubjectFull: Biomarkers blood
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Aging physiology
        Type: general
      – SubjectFull: Geroscience trends
        Type: general
      – SubjectFull: Geriatrics trends
        Type: general
    Titles:
      – TitleFull: Biological aging for the advancement of biogerontology: Between hopes and hypes.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Marzetti E
      – PersonEntity:
          Name:
            NameFull: Picca A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1760-4788
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: The journal of nutrition, health & aging
              Type: main
ResultId 1