Academic Journal
Circulating asparagine and short stature: A case-control study and exploratory two-sample Mendelian randomization analysis.
| Τίτλος: | Circulating asparagine and short stature: A case-control study and exploratory two-sample Mendelian randomization analysis. |
|---|---|
| Συγγραφείς: | Chen D; Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China., Ling K, Zhang S, Zhou H, Wang J |
| Πηγή: | Medicine [Medicine (Baltimore)] 2026 Sep 25; Vol. 105 (39), pp. e50762. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| Ιατρικοί όροι (MeSH): | Asparagine*/blood , Body Height*/genetics , Growth Disorders*/blood , Growth Disorders*/genetics , Dwarfism*/blood , Dwarfism*/genetics , Mendelian Randomization Analysis*, Humans ; Case-Control Studies ; Female ; Child ; Male |
| Περίληψη: | Short stature is phenotypically heterogeneous, and the role of circulating amino acids remains unclear. We compared plasma asparagine concentrations in children with short stature and healthy controls and examined genetically predicted circulating metabolites using two-sample Mendelian randomization (MR). We included 96 children with a clinical record diagnosis of short stature and 96 healthy controls. Plasma asparagine was measured by enzyme-linked immunosorbent assay, and the 2 groups were compared using the Mann-Whitney U test. Summary statistics for 1091 plasma metabolites and 309 metabolite ratios were screened against a European-ancestry short-stature outcome using two-sample MR. Benjamini-Hochberg false discovery rate correction was applied across 1400 inverse-variance weighted tests. Median plasma asparagine was 54.80 ng/L (interquartile range = 50.38-64.60) in children with short stature and 84.06 ng/L (71.00-95.35) in controls (P < .001). Five metabolite exposures met the nominal inverse-variance weighted threshold and sensitivity filters. Genetically predicted plasma free asparagine was inversely associated with short stature (odds ratio = 0.565; 95% confidence interval = 0.420-0.759; P = .00015; q = .106). None of the 1400 tests met q < .10. Children with short stature had lower plasma asparagine than controls. The MR estimate was in the same direction but did not survive multiple-testing correction. These data do not establish causality or support asparagine supplementation. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, LLC.) |
| Competing Interests: | The authors have no conflicts of interest to declare. |
| References: | Osteoarthritis Cartilage. 2021 Dec;29(12):1741-1750. (PMID: 34425228) Nat Rev Endocrinol. 2015 Dec;11(12):735-46. (PMID: 26437621) Clin Sci (Lond). 2019 Mar 25;133(6):777-788. (PMID: 30867230) JAMA. 2021 Oct 26;326(16):1614-1621. (PMID: 34698778) BMC Musculoskelet Disord. 2024 Dec 6;25(1):1004. (PMID: 39639271) Nat Genet. 2020 Oct;52(10):1036-1045. (PMID: 32929287) Molecules. 2024 Apr 07;29(7):. (PMID: 38611940) J Pediatr. 2014 May;164(5 Suppl):S1-14.e6. (PMID: 24731744) Front Pharmacol. 2022 May 05;13:818952. (PMID: 35600884) EBioMedicine. 2016 Apr;6:246-252. (PMID: 27211567) Nat Genet. 2023 Jan;55(1):44-53. (PMID: 36635386) Nat Genet. 2021 Feb;53(2):156-165. (PMID: 33462485) Nat Commun. 2016 Apr 29;7:11457. (PMID: 27126896) J Biol Chem. 2020 Mar 6;295(10):2890-2899. (PMID: 32019866) |
| Grant Information: | 2025CGW059 Public Welfare Research Project of Jiaxing |
| Contributed Indexing: | Keywords: Mendelian randomization; asparagine; case-control study; metabolomics; short stature |
| Substance Nomenclature: | 7006-34-0 (Asparagine) |
| Entry Date(s): | Date Created: 20260926 Date Completed: 20260926 Latest Revision: 20260930 |
| Update Code: | 20260930 |
| PubMed Central ID: | PMC13619224 |
| DOI: | 10.1097/MD.0000000000050762 |
| PMID: | 42798035 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!