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Synthetic FLS2 receptor oligomer boosts plant innate immunity.

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Τίτλος: Synthetic FLS2 receptor oligomer boosts plant innate immunity.
Συγγραφείς: Ma Z; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Yazhouwan National Laboratory, Sanya 572024, Hainan, China., Xie Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Zhu X; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Chng CP; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Liang Q; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Huang C; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Miao Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore.
Πηγή: Science advances [Sci Adv] 2026 Sep 25; Vol. 12 (39), pp. eaeg6872. Date of Electronic Publication: 2026 Sep 25.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Imprint Name(s): Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
Ιατρικοί όροι (MeSH): Arabidopsis*/immunology , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Protein Kinases*/metabolism , Protein Kinases*/chemistry , Protein Kinases*/genetics , Plant Immunity* , Immunity, Innate* , Protein Multimerization*, Signal Transduction ; Innate Immunity Recognition
Περίληψη: The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and sustained signaling in plant innate immunity remains unclear, owing to the inherent complexity of their dynamic associations. Using a synthetic engineering approach, we precisely controlled the oligomerization states of the Arabidopsis FLS2 receptor. Single-particle imaging with quantitative calibration revealed that FLS2 transits from a predominantly monomeric resting state to transient homo-association at dimeric configuration upon activation. We then showed that synthetically engineered receptor homo-dimeric association markedly enhances plant defense responses while avoids dysfunctional high-order assemblies, which inhibit dynamic receptor replenishment and thus defect in long-lasting immune activities. Our findings highlight precise receptor assembly control for both immediate activation and long-term signaling, offering strategies for engineering durable plant immune responses.
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Substance Nomenclature: 0 (Arabidopsis Proteins)
EC 2.7.- (Protein Kinases)
EC 2.7.1.- (FLS2 protein, Arabidopsis)
Entry Date(s): Date Created: 20260925 Date Completed: 20260925 Latest Revision: 20260928
Update Code: 20260928
PubMed Central ID: PMC13614395
DOI: 10.1126/sciadv.aeg6872
PMID: 42789702
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2375-2548
DOI:10.1126/sciadv.aeg6872