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Synthetic FLS2 receptor oligomer boosts plant innate immunity.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Synthetic FLS2 receptor oligomer boosts plant innate immunity.
Συγγραφείς: Ma Z; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Yazhouwan National Laboratory, Sanya 572024, Hainan, China., Xie Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Zhu X; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Chng CP; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Liang Q; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Huang C; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Miao Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore.
Πηγή: Science advances [Sci Adv] 2026 Sep 25; Vol. 12 (39), pp. eaeg6872. Date of Electronic Publication: 2026 Sep 25.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Imprint Name(s): Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
Ιατρικοί όροι (MeSH): Arabidopsis*/immunology , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Protein Kinases*/metabolism , Protein Kinases*/chemistry , Protein Kinases*/genetics , Plant Immunity* , Immunity, Innate* , Protein Multimerization*, Signal Transduction ; Innate Immunity Recognition
Περίληψη: The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and sustained signaling in plant innate immunity remains unclear, owing to the inherent complexity of their dynamic associations. Using a synthetic engineering approach, we precisely controlled the oligomerization states of the Arabidopsis FLS2 receptor. Single-particle imaging with quantitative calibration revealed that FLS2 transits from a predominantly monomeric resting state to transient homo-association at dimeric configuration upon activation. We then showed that synthetically engineered receptor homo-dimeric association markedly enhances plant defense responses while avoids dysfunctional high-order assemblies, which inhibit dynamic receptor replenishment and thus defect in long-lasting immune activities. Our findings highlight precise receptor assembly control for both immediate activation and long-term signaling, offering strategies for engineering durable plant immune responses.
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Cell. 2002 Sep 20;110(6):669-72. (PMID: 12297041)
Plant J. 2007 Sep;51(5):931-40. (PMID: 17651370)
J Cell Sci. 2020 Aug 6;133(15):. (PMID: 32616560)
Science. 2013 Nov 1;342(6158):624-8. (PMID: 24114786)
Nat Rev Immunol. 2016 Sep;16(9):537-52. (PMID: 27477127)
Cell Host Microbe. 2015 Jun 10;17(6):752-62. (PMID: 26067603)
Biophys J. 2015 Nov 3;109(9):1798-806. (PMID: 26536257)
Nat Commun. 2019 Apr 15;10(1):1734. (PMID: 30988307)
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):517-22. (PMID: 11756663)
Plant Biotechnol J. 2022 Oct;20(10):1853-1855. (PMID: 35880295)
Cell. 2024 Apr 25;187(9):2095-2116. (PMID: 38670067)
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18232-7. (PMID: 24108355)
Plant Physiol. 2019 May;180(1):543-558. (PMID: 30782965)
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):496-501. (PMID: 20018686)
Nat Commun. 2023 Jan 11;14(1):164. (PMID: 36631495)
Elife. 2017 Mar 06;6:. (PMID: 28262094)
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Nat Commun. 2023 Jul 19;14(1):4345. (PMID: 37468504)
Development. 2018 Oct 1;145(19):. (PMID: 30228101)
Nat Chem Biol. 2021 Jun;17(6):693-702. (PMID: 34035521)
Plant Cell. 2012 Oct;24(10):4205-19. (PMID: 23085733)
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12805-10. (PMID: 22689944)
Mol Cell. 2022 Oct 6;82(19):3693-3711.e10. (PMID: 36108633)
J Cell Biol. 2011 Feb 7;192(3):463-80. (PMID: 21300851)
Nat Plants. 2015 Oct 05;1:15140. (PMID: 27251392)
J Biol Chem. 2010 Mar 26;285(13):9444-9451. (PMID: 20103591)
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10104-9. (PMID: 16785433)
Cell Host Microbe. 2014 Mar 12;15(3):329-38. (PMID: 24629339)
Opt Express. 2019 Jul 22;27(15):21239-21252. (PMID: 31510207)
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Cell Rep. 2021 Mar 30;34(13):108884. (PMID: 33789103)
Mol Cell Proteomics. 2007 Jul;6(7):1198-214. (PMID: 17317660)
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Mol Cell. 2021 Sep 2;81(17):3449-3467. (PMID: 34403694)
Mol Plant. 2015 Apr;8(4):521-39. (PMID: 25744358)
Elife. 2016 Mar 28;5:. (PMID: 27017828)
Nature. 2006 Nov 16;444(7117):323-9. (PMID: 17108957)
Methods Appl Fluoresc. 2020 Feb 20;8(2):024005. (PMID: 32028271)
Elife. 2018 Jan 24;7:. (PMID: 29368691)
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11034-9. (PMID: 27651493)
Genes Dev. 2006 Mar 1;20(5):537-42. (PMID: 16510871)
Annu Rev Phytopathol. 2017 Aug 4;55:257-286. (PMID: 28617654)
Mol Plant. 2023 Jan 2;16(1):75-95. (PMID: 36415130)
J Leukoc Biol. 2019 Feb;105(2):339-351. (PMID: 30256449)
Substance Nomenclature: 0 (Arabidopsis Proteins)
EC 2.7.- (Protein Kinases)
EC 2.7.1.- (FLS2 protein, Arabidopsis)
Entry Date(s): Date Created: 20260925 Date Completed: 20260925 Latest Revision: 20260928
Update Code: 20260928
PubMed Central ID: PMC13614395
DOI: 10.1126/sciadv.aeg6872
PMID: 42789702
Βάση Δεδομένων: MEDLINE
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  Data: Synthetic FLS2 receptor oligomer boosts plant innate immunity.
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  Data: <searchLink fieldCode="AU" term="%22Ma+Z%22">Ma Z</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Yazhouwan National Laboratory, Sanya 572024, Hainan, China.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Chng+CP%22">Chng CP</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.<br /><searchLink fieldCode="AU" term="%22Liang+Q%22">Liang Q</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.<br /><searchLink fieldCode="AU" term="%22Miao+Y%22">Miao Y</searchLink>; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore.
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  Data: The gradual assembly and oligomerization of cell surface receptors are critical for regulating immune activation and turnover. Yet, how dynamic, spatiotemporally regulated assembly enables rapid and sustained signaling in plant innate immunity remains unclear, owing to the inherent complexity of their dynamic associations. Using a synthetic engineering approach, we precisely controlled the oligomerization states of the Arabidopsis FLS2 receptor. Single-particle imaging with quantitative calibration revealed that FLS2 transits from a predominantly monomeric resting state to transient homo-association at dimeric configuration upon activation. We then showed that synthetically engineered receptor homo-dimeric association markedly enhances plant defense responses while avoids dysfunctional high-order assemblies, which inhibit dynamic receptor replenishment and thus defect in long-lasting immune activities. Our findings highlight precise receptor assembly control for both immediate activation and long-term signaling, offering strategies for engineering durable plant immune responses.
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  Group: RefInfo
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        StartPage: eaeg6872
    Subjects:
      – SubjectFull: Signal Transduction
        Type: general
      – SubjectFull: Innate Immunity Recognition
        Type: general
      – SubjectFull: Arabidopsis immunology
        Type: general
      – SubjectFull: Arabidopsis genetics
        Type: general
      – SubjectFull: Arabidopsis metabolism
        Type: general
      – SubjectFull: Arabidopsis Proteins chemistry
        Type: general
      – SubjectFull: Arabidopsis Proteins metabolism
        Type: general
      – SubjectFull: Arabidopsis Proteins genetics
        Type: general
      – SubjectFull: Protein Kinases metabolism
        Type: general
      – SubjectFull: Protein Kinases chemistry
        Type: general
      – SubjectFull: Protein Kinases genetics
        Type: general
      – SubjectFull: Plant Immunity
        Type: general
      – SubjectFull: Immunity, Innate
        Type: general
      – SubjectFull: Protein Multimerization
        Type: general
    Titles:
      – TitleFull: Synthetic FLS2 receptor oligomer boosts plant innate immunity.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ma Z
      – PersonEntity:
          Name:
            NameFull: Xie Y
      – PersonEntity:
          Name:
            NameFull: Zhu X
      – PersonEntity:
          Name:
            NameFull: Chng CP
      – PersonEntity:
          Name:
            NameFull: Liang Q
      – PersonEntity:
          Name:
            NameFull: Huang C
      – PersonEntity:
          Name:
            NameFull: Miao Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 09
              Text: 2026 Sep 25
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2375-2548
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 39
          Titles:
            – TitleFull: Science advances
              Type: main
ResultId 1