Academic Journal
Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation.
| Τίτλος: | Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation. |
|---|---|
| Συγγραφείς: | Bahraminasab M; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Rashdi JS; Animal and Veterinary sciences, Sultan Qaboos University, Muscat, Muscat Governorate, Oman., Darweesh M; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Mohammadi S; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Amri IS; Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, 616, Oman., Al-Harrasi A; Natural and Medical Science Research Center, University of Nizwa, Nizwa 616, Ad Dakhiliyah, Oman., Al-Roshdi MR; Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, 616, Oman. m.alroshdi@unizwa.edu.om. |
| Πηγή: | Molecular biology reports [Mol Biol Rep] 2026 Sep 25; Vol. 53 (1). Date of Electronic Publication: 2026 Sep 25. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Dordrecht, Boston, Reidel. |
| Ιατρικοί όροι (MeSH): | Stress Granules*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Cellular Senescence*/physiology , Cellular Senescence*/genetics , Inflammation*/metabolism , Inflammation*/genetics , Stress, Physiological*, Humans ; Signal Transduction ; Animals ; cGAS-STING Signaling Pathway ; Senescence-Associated Secretory Phenotype |
| Περίληψη: | Cellular senescence is a complex stress response characterized not only by stable growth arrest but also by chromatin remodeling, altered proteostasis, metabolic adaptation, innate immune activation, and the senescence-associated secretory phenotype. Stress granules (SGs) are dynamic membraneless ribonucleoprotein condensates that form during translational stress and regulate mRNA triage, signaling and recovery. While both senescence and SGs represent important features of cellular stress response, the mechanisms underlying their intersection remain poorly defined. This review examines how the biology of SGs and RNA-binding proteins (RBPs) regulate senescence, with particular emphasis on stress granule-induced inflammation associated with SASP, activation of cGAS-STING, induction of NF- κB signaling, and interferon response. We discuss the differential ability of senescence inducers to generate canonical SGs and why SG formation does not necessarily result in global translational shutdown. In addition, we examine the potential roles of SG-associated RBPs, including G3BP1/2, TIA1/TIAR, CAPRIN1, USP10, HuR, ZFP36 family, FXR1, and TDP-43 together with methodological standards for identifying SGs in senescence. We present a stage-resolved modular framework describing the context-dependent functions of SG-associated RBPs throughout senescence progression and discuss therapeutic opportunities. Overall, this review suggests that stress granules and associated RNA-binding proteins should be considered context-dependent components in inflammation-driven senescence, rather than universal inducers of senescence onset. (© 2026. The Author(s), under exclusive licence to Springer Nature B.V.) |
| Competing Interests: | Declarations. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Consent to participate: Not applicable. |
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| Contributed Indexing: | Keywords: Biomolecular condensates; Cellular senescence; Inflammatory remodeling; Integrated stress response; RNA binding proteins; Stress granules |
| Substance Nomenclature: | 0 (RNA-Binding Proteins) |
| Entry Date(s): | Date Created: 20260925 Date Completed: 20260925 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s11033-026-12735-5 |
| PMID: | 42789125 |
| Βάση Δεδομένων: | MEDLINE |
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