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epiTOol: a browser-based HLA epitope (mis)matching application for small to large cohorts.

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Τίτλος: epiTOol: a browser-based HLA epitope (mis)matching application for small to large cohorts.
Συγγραφείς: Lehmann C; Institute for Transfusion Medicine, HLA Laboratory, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Institute for Clinical Immunology, University of Leipzig, Leipzig, Germany., Lachmann N; Institute for Transfusion Medicine, H & I Laboratory, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany., Doxiadis I; Institute for Transfusion Medicine, HLA Laboratory, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Institute for Clinical Immunology, University of Leipzig, Leipzig, Germany., Loeffler-Wirth H; Interdisciplinary Centre for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of, Leipzig, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Πηγή: Frontiers in immunology [Front Immunol] 2026 Sep 07; Vol. 17, pp. 1916548. Date of Electronic Publication: 2026 Sep 07 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Imprint Name(s): Original Publication: [Lausanne : Frontiers Research Foundation]
Ιατρικοί όροι (MeSH): HLA Antigens*/immunology , HLA Antigens*/genetics , Histocompatibility Testing*/methods , Epitopes*/immunology , Epitopes*/genetics , Epitope Mapping*/methods , Software* , Web Browser*, Humans
Περίληψη: Method: epiTOol is a web-based application for transplantation immunogenetics and immunology, providing easy and reliable translation of high-resolution HLA typing into either predicted or confirmed epitopes. Unacceptable or acceptable HLA incompatibilities or mismatches are then easily definable, and the data is exported for further analyses. Unlike other similar tools, epiTOol allows for upload and analysis of large datasets of patient-donor combinations without the need for manual data entry. The results can be directly exported in table and text format for subsequent utilization in medical reports or data sheets.
Conclusion: epiTOol is designed for utilization in research activities dedicated to transplantation immunology in respective centers dealing with solid organ transplantation but will also be applicable to stem cell transplantation since the role of HLA-specific antibodies also increases dramatically here.
(Copyright © 2026 Lehmann, Lachmann, Doxiadis and Loeffler-Wirth.)
Competing Interests: The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References: HLA. 2020 Jul;96(1):43-51. (PMID: 32227681)
Clin Transplant Res. 2025 Sep 30;39(3):183-199. (PMID: 40931644)
Transpl Int. 2025 Aug 13;38:14716. (PMID: 40881320)
Transfus Med Hemother. 2024 Apr 22;51(3):152-157. (PMID: 38867808)
Curr Opin Organ Transplant. 2020 Aug;25(4):412-419. (PMID: 32520786)
Am J Transplant. 2025 Jun;25(6):1149-1151. (PMID: 39855343)
Transpl Immunol. 2014 Jun;31(1):1-6. (PMID: 24769079)
Kidney Int Rep. 2021 May 01;6(6):1500-1502. (PMID: 34169190)
Hum Immunol. 2006 Nov;67(11):847-62. (PMID: 17145365)
Pediatr Transplant. 2016 Nov;20(7):884-885. (PMID: 27781364)
Front Immunol. 2024 May 22;15:1384823. (PMID: 38840925)
Front Immunol. 2023 Jan 27;14:1094862. (PMID: 36776892)
Front Immunol. 2026 Jun 09;17:1846251. (PMID: 42344929)
Tissue Antigens. 2009 Feb;73(2):95-170. (PMID: 19140825)
Front Transplant. 2025 Dec 08;4:1710058. (PMID: 41438158)
Hum Immunol. 2022 Mar;83(3):248-255. (PMID: 35101308)
Int J Immunogenet. 2013 Feb;40(1):54-9. (PMID: 23136897)
Contributed Indexing: Keywords: HLA-antibodies; epiTOol; eplets; interactive epitope matching; predicted and confirmed epitopes
Substance Nomenclature: 0 (HLA Antigens)
0 (Epitopes)
Entry Date(s): Date Created: 20260922 Date Completed: 20260922 Latest Revision: 20260923
Update Code: 20260923
PubMed Central ID: PMC13590771
DOI: 10.3389/fimmu.2026.1916548
PMID: 42769449
Βάση Δεδομένων: MEDLINE
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  Data: epiTOol: a browser-based HLA epitope (mis)matching application for small to large cohorts.
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  Data: <searchLink fieldCode="AU" term="%22Lehmann+C%22">Lehmann C</searchLink>; Institute for Transfusion Medicine, HLA Laboratory, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Institute for Clinical Immunology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Lachmann+N%22">Lachmann N</searchLink>; Institute for Transfusion Medicine, H & I Laboratory, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Doxiadis+I%22">Doxiadis I</searchLink>; Institute for Transfusion Medicine, HLA Laboratory, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Institute for Clinical Immunology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Loeffler-Wirth+H%22">Loeffler-Wirth H</searchLink>; Interdisciplinary Centre for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of, Leipzig, Leipzig, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Sep 07; Vol. 17, pp. 1916548. <i>Date of Electronic Publication: </i>2026 Sep 07 (<i>Print Publication: </i>2026).
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  Data: <searchLink fieldCode="MM" term="%22HLA+Antigens%22">HLA Antigens*</searchLink>/<searchLink fieldCode="MM" term="%22HLA+Antigens+immunology%22">immunology</searchLink> <br /><searchLink fieldCode="MM" term="%22HLA+Antigens%22">HLA Antigens*</searchLink>/<searchLink fieldCode="MM" term="%22HLA+Antigens+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Histocompatibility+Testing%22">Histocompatibility Testing*</searchLink>/<searchLink fieldCode="MM" term="%22Histocompatibility+Testing+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Epitopes%22">Epitopes*</searchLink>/<searchLink fieldCode="MM" term="%22Epitopes+immunology%22">immunology</searchLink> <br /><searchLink fieldCode="MM" term="%22Epitopes%22">Epitopes*</searchLink>/<searchLink fieldCode="MM" term="%22Epitopes+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Epitope+Mapping%22">Epitope Mapping*</searchLink>/<searchLink fieldCode="MM" term="%22Epitope+Mapping+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Software%22">Software*</searchLink> <br /><searchLink fieldCode="MM" term="%22Web+Browser%22">Web Browser*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
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  Data: Method: epiTOol is a web-based application for transplantation immunogenetics and immunology, providing easy and reliable translation of high-resolution HLA typing into either predicted or confirmed epitopes. Unacceptable or acceptable HLA incompatibilities or mismatches are then easily definable, and the data is exported for further analyses. Unlike other similar tools, epiTOol allows for upload and analysis of large datasets of patient-donor combinations without the need for manual data entry. The results can be directly exported in table and text format for subsequent utilization in medical reports or data sheets.<br />Conclusion: epiTOol is designed for utilization in research activities dedicated to transplantation immunology in respective centers dealing with solid organ transplantation but will also be applicable to stem cell transplantation since the role of HLA-specific antibodies also increases dramatically here.<br /> (Copyright © 2026 Lehmann, Lachmann, Doxiadis and Loeffler-Wirth.)
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  Data: The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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  Data: HLA. 2020 Jul;96(1):43-51. (PMID: <searchLink fieldCode="PM" term="%2232227681%22">32227681)</searchLink><br />Clin Transplant Res. 2025 Sep 30;39(3):183-199. (PMID: <searchLink fieldCode="PM" term="%2240931644%22">40931644)</searchLink><br />Transpl Int. 2025 Aug 13;38:14716. (PMID: <searchLink fieldCode="PM" term="%2240881320%22">40881320)</searchLink><br />Transfus Med Hemother. 2024 Apr 22;51(3):152-157. (PMID: <searchLink fieldCode="PM" term="%2238867808%22">38867808)</searchLink><br />Curr Opin Organ Transplant. 2020 Aug;25(4):412-419. (PMID: <searchLink fieldCode="PM" term="%2232520786%22">32520786)</searchLink><br />Am J Transplant. 2025 Jun;25(6):1149-1151. (PMID: <searchLink fieldCode="PM" term="%2239855343%22">39855343)</searchLink><br />Transpl Immunol. 2014 Jun;31(1):1-6. (PMID: <searchLink fieldCode="PM" term="%2224769079%22">24769079)</searchLink><br />Kidney Int Rep. 2021 May 01;6(6):1500-1502. (PMID: <searchLink fieldCode="PM" term="%2234169190%22">34169190)</searchLink><br />Hum Immunol. 2006 Nov;67(11):847-62. (PMID: <searchLink fieldCode="PM" term="%2217145365%22">17145365)</searchLink><br />Pediatr Transplant. 2016 Nov;20(7):884-885. (PMID: <searchLink fieldCode="PM" term="%2227781364%22">27781364)</searchLink><br />Front Immunol. 2024 May 22;15:1384823. (PMID: <searchLink fieldCode="PM" term="%2238840925%22">38840925)</searchLink><br />Front Immunol. 2023 Jan 27;14:1094862. (PMID: <searchLink fieldCode="PM" term="%2236776892%22">36776892)</searchLink><br />Front Immunol. 2026 Jun 09;17:1846251. (PMID: <searchLink fieldCode="PM" term="%2242344929%22">42344929)</searchLink><br />Tissue Antigens. 2009 Feb;73(2):95-170. (PMID: <searchLink fieldCode="PM" term="%2219140825%22">19140825)</searchLink><br />Front Transplant. 2025 Dec 08;4:1710058. (PMID: <searchLink fieldCode="PM" term="%2241438158%22">41438158)</searchLink><br />Hum Immunol. 2022 Mar;83(3):248-255. (PMID: <searchLink fieldCode="PM" term="%2235101308%22">35101308)</searchLink><br />Int J Immunogenet. 2013 Feb;40(1):54-9. (PMID: <searchLink fieldCode="PM" term="%2223136897%22">23136897)</searchLink>
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