Academic Journal
25-Hydroxyvitamin D Sufficiency Is Associated With Reduced Atelectasis in Common Variable Immunodeficiency: A Cross-Sectional Study.
| Τίτλος: | 25-Hydroxyvitamin D Sufficiency Is Associated With Reduced Atelectasis in Common Variable Immunodeficiency: A Cross-Sectional Study. |
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| Συγγραφείς: | Silveira C; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil., Barros MT; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil., Coutinho Martins É; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil., Grecco O; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil., Kokron C; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Institute for Investigation in Immunology, National Institute of Science and Technology (iii-INCT), University of São Paulo, São Paulo, SP, Brazil., Kalil J; Division of Clinical Immunology and Allergy, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Institute for Investigation in Immunology, National Institute of Science and Technology (iii-INCT), University of São Paulo, São Paulo, SP, Brazil. |
| Πηγή: | Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2026 Sep 18; Vol. 32, pp. e953313. Date of Electronic Publication: 2026 Sep 18. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Electronic Cited Medium: Internet ISSN: 1643-3750 (Electronic) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2014- : Smithtown, NY : International Scientific Information, Inc. Original Publication: Warsaw, Poland : Medical Science International |
| Ιατρικοί όροι (MeSH): | Common Variable Immunodeficiency*/complications , Common Variable Immunodeficiency*/blood , Vitamin D*/analogs & derivatives , Vitamin D*/blood , Pulmonary Atelectasis*/blood , Pulmonary Atelectasis*/etiology, Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Humans ; Cross-Sectional Studies ; Female ; Male ; Retrospective Studies ; Adult ; Middle Aged ; Bronchiectasis ; Pulmonary Disease, Chronic Obstructive |
| Περίληψη: | BACKGROUND Common variable immunodeficiency (CVID) is an inborn error of immunity characterized by impaired antibody production, poor vaccine responses, and reduced serum immunoglobulin levels, resulting in respiratory manifestations that can progress to pulmonary complications. Although vitamin D has been associated with pulmonary outcomes in other populations, the association between serum 25-hydroxyvitamin D [25(OH)D] status and pulmonary manifestations, particularly atelectasis, in CVID remains unclear. MATERIAL AND METHODS We conducted a retrospective cross-sectional study of 48 adult patients with CVID stratified by serum 25(OH)D concentration (<30 ng/mL [insufficient] vs ≥30 ng/mL [sufficient]). Pulmonary outcomes (atelectasis, bronchiectasis, recurrent pneumonia, and chronic obstructive pulmonary disease [COPD]) were obtained from medical records. Associations were assessed via Fisher's exact test. Exploratory analyses included a longitudinal imaging review and descriptive Kaplan-Meier curves illustrating atelectasis-free disease duration by baseline 25(OH)D status. RESULTS Among 48 patients, 35 (73%) had 25(OH)D concentrations below 30 ng/mL. Atelectasis was more frequent in the insufficient group (15/35; 43%) (odds ratio=0.12; 95% confidence interval, 0.01-0.97; P=0.02). No significant associations were observed for bronchiectasis (63% vs 46%; P=0.53), recurrent pneumonia (91% vs 84%; P=0.49), or COPD (3% vs 8%; P=0.46). Kaplan-Meier curves did not show an apparent separation between groups. CONCLUSIONS Serum 25(OH)D sufficiency was associated with lower atelectasis prevalence in patients with CVID. This finding reflects a cross-sectional association and does not establish causality; it supports a potential link between 25(OH)D status and atelectasis. Prospective studies are needed to further evaluate this relationship. |
| References: | J Nutr. 2025 Feb;155(2):621-633. (PMID: 39716659) Int J Mol Sci. 2026 Jan 05;27(1):. (PMID: 41516427) Endocr Metab Immune Disord Drug Targets. 2024;24(2):242-254. (PMID: 37608677) Front Immunol. 2021 Mar 10;12:627423. (PMID: 33777011) Eur Respir Rev. 2021 Dec 15;30(162):. (PMID: 34911693) J Investig Allergol Clin Immunol. 2024 Jul;34(4):233-245. (PMID: 39077769) Pulm Circ. 2025 Jan 01;15(1):e70034. (PMID: 39744645) Arq Bras Endocrinol Metabol. 2014 Jul;58(5):411-33. (PMID: 25166032) Nat Immunol. 2022 Jan;23(1):62-74. (PMID: 34764490) Front Immunol. 2021 Mar 11;12:605945. (PMID: 33776995) J Steroid Biochem Mol Biol. 2023 Apr;228:106253. (PMID: 36657728) Eur Radiol. 2024 Jun;34(6):4142-4154. (PMID: 37935849) Clin Immunol. 2023 Dec;257:109816. (PMID: 37918468) J Clin Endocrinol Metab. 2024 Jul 12;109(8):1907-1947. (PMID: 38828931) J Clin Immunol. 2023 Nov;43(8):2208-2220. (PMID: 37932514) Front Immunol. 2025 May 15;16:1589052. (PMID: 40443662) Clin Immunol. 1999 Jul;92(1):34-48. (PMID: 10413651) J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1763-1770. (PMID: 30776527) Front Immunol. 2023 Jul 14;14:950465. (PMID: 37520529) An Acad Bras Cienc. 2004 Dec;76(4):707-26. (PMID: 15558152) Int J Mol Sci. 2023 Apr 14;24(8):. (PMID: 37108455) Biochem Pharmacol. 2020 Jul;177:113955. (PMID: 32251673) Nutrients. 2022 Apr 02;14(7):. (PMID: 35406098) Int J Mol Sci. 2025 May 16;26(10):. (PMID: 40429939) Med Sci Monit. 2021 Jan 18;27:e926748. (PMID: 33456047) Lung India. 2020 Sep-Oct;37(5):421-424. (PMID: 32883903) J Nutr Biochem. 2022 Nov;109:109105. (PMID: 35858666) Sci Rep. 2022 Apr 29;12(1):7065. (PMID: 35487970) Front Immunol. 2021 Mar 23;12:620709. (PMID: 33833753) J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. (PMID: 26563668) Radiology. 2024 Feb;310(2):e232558. (PMID: 38411514) Biomedicines. 2022 Mar 09;10(3):. (PMID: 35327437) BMJ. 2017 Feb 15;356:i6583. (PMID: 28202713) Rev Alerg Mex. 2013 Jul-Sep;60(3):110-6. (PMID: 24274606) |
| Substance Nomenclature: | A288AR3C9H (25-hydroxyvitamin D) 1406-16-2 (Vitamin D) |
| Entry Date(s): | Date Created: 20260918 Date Completed: 20260918 Latest Revision: 20260924 |
| Update Code: | 20260924 |
| PubMed Central ID: | PMC13596011 |
| DOI: | 10.12659/MSM.953313 |
| PMID: | 42758666 |
| Βάση Δεδομένων: | MEDLINE |
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