Academic Journal
A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion.
| Τίτλος: | A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion. |
|---|---|
| Συγγραφείς: | Wang Y; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Mi J; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Cao X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Wang M; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.; Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Feng H; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Kong F; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Zhang X; Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Tianjin Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, China., Liu X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China. |
| Πηγή: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 Sep 03; Vol. 16, pp. 1917604. Date of Electronic Publication: 2026 Sep 03 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Media SA |
| Ιατρικοί όροι (MeSH): | Biofilms*/drug effects , Biofilms*/growth & development , Biofilms*/radiation effects , Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Anti-Bacterial Agents*/pharmacology , Biomimetics*/methods , Biomimetic Materials*/pharmacology, Gold/chemistry ; Microbial Viability/drug effects ; Dental Caries/microbiology ; Dental Caries/therapy ; Metal Nanoparticles/chemistry ; Humans ; Animals |
| Περίληψη: | Background: Dental caries, primarily driven by Streptococcus mutans (S. mutans) biofilms, remains a formidable clinical challenge due to the protective extracellular polymeric substance (EPS) matrix and the limited efficacy of conventional antibiotics. Methods: To address this, we report a biomimetic photothermal nanoplatform (FWA NPs) featuring a hierarchical, urchin-like multi-spiked architecture, synthesized via the co-assembly of ferrocene-tryptophan conjugates and in situ biomineralized gold nanoparticles. Results: Benefiting from this unique topological structure, FWA NPs maximize interfacial interactions with bacterial membranes and exhibit enhanced near-infrared absorption, achieving a remarkable photothermal conversion efficiency of 54.4%. Under 808 nm near-infrared (NIR) irradiation, this rapid and localized heat generation induced efficient eradication of S. mutans, which manifested as a dramatic reduction in bacterial colonies from ~107 to ~105 CFU/mL and irreversible membrane damage characterized by massive surface wrinkling, localized collapse, and membrane rupture. Additionally, FWA NPs reduced the survival rate of S. mutans biofilms to approximately 10%, Crucially, FWA NPs demonstrated excellent biocompatibility with a hemolysis rate of approximately 1% for red blood cells and a relative survival rate of 90% for normal cells. Conclusion: By synergistically integrating topological advantages with highly efficient energy conversion, this rationally designed nanoplatform offers a highly effective, non-antibiotic therapeutic paradigm for combating biofilm-associated oral infections and mitigating the global threat of antimicrobial resistance. (Copyright © 2026 Wang, Mi, Cao, Wang, Feng, Kong, Zhang and Liu.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: Streptococcus mutans; biomimetic nanomaterial; oral biofilm elimination; photothermal therapy; sea urchin-like gold nanoparticles |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) 7440-57-5 (Gold) |
| Entry Date(s): | Date Created: 20260918 Date Completed: 20260918 Latest Revision: 20260919 |
| Update Code: | 20260919 |
| PubMed Central ID: | PMC13581847 |
| DOI: | 10.3389/fcimb.2026.1917604 |
| PMID: | 42755848 |
| Βάση Δεδομένων: | MEDLINE |
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