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A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion.

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Τίτλος: A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion.
Συγγραφείς: Wang Y; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Mi J; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Cao X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Wang M; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.; Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Feng H; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Kong F; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Zhang X; Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Tianjin Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, China., Liu X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.
Πηγή: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 Sep 03; Vol. 16, pp. 1917604. Date of Electronic Publication: 2026 Sep 03 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
Imprint Name(s): Original Publication: Lausanne : Frontiers Media SA
Ιατρικοί όροι (MeSH): Biofilms*/drug effects , Biofilms*/growth & development , Biofilms*/radiation effects , Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Anti-Bacterial Agents*/pharmacology , Biomimetics*/methods , Biomimetic Materials*/pharmacology, Gold/chemistry ; Microbial Viability/drug effects ; Dental Caries/microbiology ; Dental Caries/therapy ; Metal Nanoparticles/chemistry ; Humans ; Animals
Περίληψη: Background: Dental caries, primarily driven by Streptococcus mutans (S. mutans) biofilms, remains a formidable clinical challenge due to the protective extracellular polymeric substance (EPS) matrix and the limited efficacy of conventional antibiotics.
Methods: To address this, we report a biomimetic photothermal nanoplatform (FWA NPs) featuring a hierarchical, urchin-like multi-spiked architecture, synthesized via the co-assembly of ferrocene-tryptophan conjugates and in situ biomineralized gold nanoparticles.
Results: Benefiting from this unique topological structure, FWA NPs maximize interfacial interactions with bacterial membranes and exhibit enhanced near-infrared absorption, achieving a remarkable photothermal conversion efficiency of 54.4%. Under 808 nm near-infrared (NIR) irradiation, this rapid and localized heat generation induced efficient eradication of S. mutans, which manifested as a dramatic reduction in bacterial colonies from ~107 to ~105 CFU/mL and irreversible membrane damage characterized by massive surface wrinkling, localized collapse, and membrane rupture. Additionally, FWA NPs reduced the survival rate of S. mutans biofilms to approximately 10%, Crucially, FWA NPs demonstrated excellent biocompatibility with a hemolysis rate of approximately 1% for red blood cells and a relative survival rate of 90% for normal cells.
Conclusion: By synergistically integrating topological advantages with highly efficient energy conversion, this rationally designed nanoplatform offers a highly effective, non-antibiotic therapeutic paradigm for combating biofilm-associated oral infections and mitigating the global threat of antimicrobial resistance.
(Copyright © 2026 Wang, Mi, Cao, Wang, Feng, Kong, Zhang and Liu.)
Competing Interests: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References: Eur J Pharm Biopharm. 2026 Jun;223:115046. (PMID: 41806926)
Adv Mater. 2024 Feb;36(7):e2306376. (PMID: 37944993)
Science. 2021 Feb 19;371(6531):783-784. (PMID: 33602844)
Trends Microbiol. 2018 Mar;26(3):229-242. (PMID: 29097091)
Microorganisms. 2023 Jun 19;11(6):. (PMID: 37375116)
Molecules. 2024 Jul 25;29(15):. (PMID: 39124888)
Mater Today Bio. 2025 May 14;32:101871. (PMID: 40496729)
Int J Biol Macromol. 2024 Aug;274(Pt 1):133287. (PMID: 38909730)
BMC Oral Health. 2025 Aug 28;25(1):1381. (PMID: 40877804)
Nat Rev Microbiol. 2020 Oct;18(10):571-586. (PMID: 32533131)
Small. 2026 Aug;22(45):e74281. (PMID: 42318681)
Oral Health Prev Dent. 2026 Jun 19;24:433-442. (PMID: 42317152)
Front Cell Infect Microbiol. 2026 Jan 05;15:1750551. (PMID: 41561077)
Int Dent J. 2025 Oct;75(5):100904. (PMID: 40714315)
Evid Based Nurs. 2023 Jul 27;:. (PMID: 37500506)
Nat Rev Microbiol. 2024 Oct;22(10):591-592. (PMID: 39271779)
Lancet Reg Health Am. 2026 Jun 08;60:101517. (PMID: 42290709)
Int Dent J. 2026 Aug;76(4):109638. (PMID: 42167025)
J Mater Chem B. 2025 Jan 2;13(2):399-428. (PMID: 39575861)
Colloids Surf B Biointerfaces. 2026 Jul;263:115593. (PMID: 41795260)
PLoS One. 2025 Jun 3;20(6):e0325138. (PMID: 40460178)
Annu Rev Microbiol. 2017 Sep 8;71:519-538. (PMID: 28697671)
Science. 2022 May 27;376(6596):934-936. (PMID: 35617380)
Front Bioeng Biotechnol. 2025 Nov 12;13:1637941. (PMID: 41311979)
Chem Commun (Camb). 2019 Apr 7;55(27):3967-3970. (PMID: 30874693)
Contributed Indexing: Keywords: Streptococcus mutans; biomimetic nanomaterial; oral biofilm elimination; photothermal therapy; sea urchin-like gold nanoparticles
Substance Nomenclature: 0 (Anti-Bacterial Agents)
7440-57-5 (Gold)
Entry Date(s): Date Created: 20260918 Date Completed: 20260918 Latest Revision: 20260919
Update Code: 20260919
PubMed Central ID: PMC13581847
DOI: 10.3389/fcimb.2026.1917604
PMID: 42755848
Βάση Δεδομένων: MEDLINE
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  Data: A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Mi+J%22">Mi J</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.; Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Feng+H%22">Feng H</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Kong+F%22">Kong F</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Tianjin Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%22101585359%22">Frontiers in cellular and infection microbiology</searchLink> [Front Cell Infect Microbiol] 2026 Sep 03; Vol. 16, pp. 1917604. <i>Date of Electronic Publication: </i>2026 Sep 03 (<i>Print Publication: </i>2026).
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  Data: Background: Dental caries, primarily driven by Streptococcus mutans (S. mutans) biofilms, remains a formidable clinical challenge due to the protective extracellular polymeric substance (EPS) matrix and the limited efficacy of conventional antibiotics.<br />Methods: To address this, we report a biomimetic photothermal nanoplatform (FWA NPs) featuring a hierarchical, urchin-like multi-spiked architecture, synthesized via the co-assembly of ferrocene-tryptophan conjugates and in situ biomineralized gold nanoparticles.<br />Results: Benefiting from this unique topological structure, FWA NPs maximize interfacial interactions with bacterial membranes and exhibit enhanced near-infrared absorption, achieving a remarkable photothermal conversion efficiency of 54.4%. Under 808 nm near-infrared (NIR) irradiation, this rapid and localized heat generation induced efficient eradication of S. mutans, which manifested as a dramatic reduction in bacterial colonies from ~107 to ~105 CFU/mL and irreversible membrane damage characterized by massive surface wrinkling, localized collapse, and membrane rupture. Additionally, FWA NPs reduced the survival rate of S. mutans biofilms to approximately 10%, Crucially, FWA NPs demonstrated excellent biocompatibility with a hemolysis rate of approximately 1% for red blood cells and a relative survival rate of 90% for normal cells.<br />Conclusion: By synergistically integrating topological advantages with highly efficient energy conversion, this rationally designed nanoplatform offers a highly effective, non-antibiotic therapeutic paradigm for combating biofilm-associated oral infections and mitigating the global threat of antimicrobial resistance.<br /> (Copyright © 2026 Wang, Mi, Cao, Wang, Feng, Kong, Zhang and Liu.)
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  Label: Competing Interests
  Group: Ab
  Data: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
– Name: Ref
  Label: References
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  Data: Eur J Pharm Biopharm. 2026 Jun;223:115046. (PMID: <searchLink fieldCode="PM" term="%2241806926%22">41806926)</searchLink><br />Adv Mater. 2024 Feb;36(7):e2306376. (PMID: <searchLink fieldCode="PM" term="%2237944993%22">37944993)</searchLink><br />Science. 2021 Feb 19;371(6531):783-784. (PMID: <searchLink fieldCode="PM" term="%2233602844%22">33602844)</searchLink><br />Trends Microbiol. 2018 Mar;26(3):229-242. (PMID: <searchLink fieldCode="PM" term="%2229097091%22">29097091)</searchLink><br />Microorganisms. 2023 Jun 19;11(6):. (PMID: <searchLink fieldCode="PM" term="%2237375116%22">37375116)</searchLink><br />Molecules. 2024 Jul 25;29(15):. (PMID: <searchLink fieldCode="PM" term="%2239124888%22">39124888)</searchLink><br />Mater Today Bio. 2025 May 14;32:101871. (PMID: <searchLink fieldCode="PM" term="%2240496729%22">40496729)</searchLink><br />Int J Biol Macromol. 2024 Aug;274(Pt 1):133287. (PMID: <searchLink fieldCode="PM" term="%2238909730%22">38909730)</searchLink><br />BMC Oral Health. 2025 Aug 28;25(1):1381. (PMID: <searchLink fieldCode="PM" term="%2240877804%22">40877804)</searchLink><br />Nat Rev Microbiol. 2020 Oct;18(10):571-586. (PMID: <searchLink fieldCode="PM" term="%2232533131%22">32533131)</searchLink><br />Small. 2026 Aug;22(45):e74281. (PMID: <searchLink fieldCode="PM" term="%2242318681%22">42318681)</searchLink><br />Oral Health Prev Dent. 2026 Jun 19;24:433-442. (PMID: <searchLink fieldCode="PM" term="%2242317152%22">42317152)</searchLink><br />Front Cell Infect Microbiol. 2026 Jan 05;15:1750551. (PMID: <searchLink fieldCode="PM" term="%2241561077%22">41561077)</searchLink><br />Int Dent J. 2025 Oct;75(5):100904. (PMID: <searchLink fieldCode="PM" term="%2240714315%22">40714315)</searchLink><br />Evid Based Nurs. 2023 Jul 27;:. (PMID: <searchLink fieldCode="PM" term="%2237500506%22">37500506)</searchLink><br />Nat Rev Microbiol. 2024 Oct;22(10):591-592. (PMID: <searchLink fieldCode="PM" term="%2239271779%22">39271779)</searchLink><br />Lancet Reg Health Am. 2026 Jun 08;60:101517. (PMID: <searchLink fieldCode="PM" term="%2242290709%22">42290709)</searchLink><br />Int Dent J. 2026 Aug;76(4):109638. (PMID: <searchLink fieldCode="PM" term="%2242167025%22">42167025)</searchLink><br />J Mater Chem B. 2025 Jan 2;13(2):399-428. (PMID: <searchLink fieldCode="PM" term="%2239575861%22">39575861)</searchLink><br />Colloids Surf B Biointerfaces. 2026 Jul;263:115593. (PMID: <searchLink fieldCode="PM" term="%2241795260%22">41795260)</searchLink><br />PLoS One. 2025 Jun 3;20(6):e0325138. (PMID: <searchLink fieldCode="PM" term="%2240460178%22">40460178)</searchLink><br />Annu Rev Microbiol. 2017 Sep 8;71:519-538. (PMID: <searchLink fieldCode="PM" term="%2228697671%22">28697671)</searchLink><br />Science. 2022 May 27;376(6596):934-936. (PMID: <searchLink fieldCode="PM" term="%2235617380%22">35617380)</searchLink><br />Front Bioeng Biotechnol. 2025 Nov 12;13:1637941. (PMID: <searchLink fieldCode="PM" term="%2241311979%22">41311979)</searchLink><br />Chem Commun (Camb). 2019 Apr 7;55(27):3967-3970. (PMID: <searchLink fieldCode="PM" term="%2230874693%22">30874693)</searchLink>
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