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Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.

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Τίτλος: Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.
Συγγραφείς: AlNasser FK; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait Ferrah99@hotmail.com., AlRashidi M; Kuwait University Health Sciences Center, Safat, Kuwait., AlRashidi A; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait., AbdelBadie M; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait.
Πηγή: BMJ case reports [BMJ Case Rep] 2026 Sep 17; Vol. 19 (9). Date of Electronic Publication: 2026 Sep 17.
Τύπος έκδοσης: Journal Article; Case Reports
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BMJ Pub. Group
Ιατρικοί όροι (MeSH): Ataxia Telangiectasia*/complications , Orbital Neoplasms*/diagnosis , Orbital Neoplasms*/diagnostic imaging , Orbital Neoplasms*/complications , Orbital Neoplasms*/drug therapy , Lymphoma, B-Cell*/diagnosis , Lymphoma, B-Cell*/complications , Cellulitis*/diagnosis , Orbital Cellulitis*, Humans ; Female ; Magnetic Resonance Imaging ; Diagnosis, Differential ; Immunocompromised Host
Περίληψη: Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder associated with immunodeficiency and an increased risk of malignancy. We report a young child with AT and severe combined immunodeficiency who initially presented with left periorbital swelling and was treated for a presumed periorbital infection. She later presented with fever and was diagnosed with pneumonia, requiring admission. Despite antimicrobial therapy and surgical drainage, the swelling persisted and progressed rapidly.MRI of the brain and orbits demonstrated complicated sinusitis with a medial extraconal lesion, suggesting an infectious process. However, there was no sustained clinical response, and microbiological studies remained negative. Repeat MRI showed a persistent lesion with extension into adjacent structures. Histopathological examination confirmed non-Hodgkin B-cell lymphoma with a high proliferative index (Ki-67~80%).This case highlights the importance of early reassessment in immunocompromised patients with an atypical clinical course.
(© BMJ Publishing Group Limited 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.)
Competing Interests: Competing interests: None declared.
Contributed Indexing: Keywords: Infections; Oncology; Ophthalmology; Paediatrics; Radiology
Entry Date(s): Date Created: 20260917 Date Completed: 20260917 Latest Revision: 20260917
Update Code: 20260918
DOI: 10.1136/bcr-2026-275016
PMID: 42754351
Βάση Δεδομένων: MEDLINE
FullText Text:
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  Data: Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.
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  Data: <searchLink fieldCode="AU" term="%22AlNasser+FK%22">AlNasser FK</searchLink>; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait Ferrah99@hotmail.com.<br /><searchLink fieldCode="AU" term="%22AlRashidi+M%22">AlRashidi M</searchLink>; Kuwait University Health Sciences Center, Safat, Kuwait.<br /><searchLink fieldCode="AU" term="%22AlRashidi+A%22">AlRashidi A</searchLink>; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait.<br /><searchLink fieldCode="AU" term="%22AbdelBadie+M%22">AbdelBadie M</searchLink>; Ophthalmology, Kuwait Ministry of Health, Sabah Al-Nasser, Kuwait.
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  Data: <searchLink fieldCode="JN" term="%22101526291%22">BMJ case reports</searchLink> [BMJ Case Rep] 2026 Sep 17; Vol. 19 (9). <i>Date of Electronic Publication: </i>2026 Sep 17.
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  Data: <searchLink fieldCode="MM" term="%22Ataxia+Telangiectasia%22">Ataxia Telangiectasia*</searchLink>/<searchLink fieldCode="MM" term="%22Ataxia+Telangiectasia+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Orbital+Neoplasms%22">Orbital Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Orbital+Neoplasms+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Orbital+Neoplasms%22">Orbital Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Orbital+Neoplasms+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Orbital+Neoplasms%22">Orbital Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Orbital+Neoplasms+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Orbital+Neoplasms%22">Orbital Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Orbital+Neoplasms+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Lymphoma%2C+B-Cell%22">Lymphoma, B-Cell*</searchLink>/<searchLink fieldCode="MM" term="%22Lymphoma%2C+B-Cell+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Lymphoma%2C+B-Cell%22">Lymphoma, B-Cell*</searchLink>/<searchLink fieldCode="MM" term="%22Lymphoma%2C+B-Cell+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Cellulitis%22">Cellulitis*</searchLink>/<searchLink fieldCode="MM" term="%22Cellulitis+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Orbital+Cellulitis%22">Orbital Cellulitis*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Magnetic+Resonance+Imaging%22">Magnetic Resonance Imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Diagnosis%2C+Differential%22">Diagnosis, Differential</searchLink> ; <searchLink fieldCode="MH" term="%22Immunocompromised+Host%22">Immunocompromised Host</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder associated with immunodeficiency and an increased risk of malignancy. We report a young child with AT and severe combined immunodeficiency who initially presented with left periorbital swelling and was treated for a presumed periorbital infection. She later presented with fever and was diagnosed with pneumonia, requiring admission. Despite antimicrobial therapy and surgical drainage, the swelling persisted and progressed rapidly.MRI of the brain and orbits demonstrated complicated sinusitis with a medial extraconal lesion, suggesting an infectious process. However, there was no sustained clinical response, and microbiological studies remained negative. Repeat MRI showed a persistent lesion with extension into adjacent structures. Histopathological examination confirmed non-Hodgkin B-cell lymphoma with a high proliferative index (Ki-67~80%).This case highlights the importance of early reassessment in immunocompromised patients with an atypical clinical course.<br /> (© BMJ Publishing Group Limited 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.)
– Name: Abstract
  Label: Competing Interests
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  Data: Competing interests: None declared.
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  Data: <i>Keywords: </i>Infections; Oncology; Ophthalmology; Paediatrics; Radiology
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  Data: <i>Date Created: </i>20260917 <i>Date Completed: </i>20260917 <i>Latest Revision: </i>20260917
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42754351
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        Value: 10.1136/bcr-2026-275016
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        Text: English
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Female
        Type: general
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      – SubjectFull: Orbital Neoplasms drug therapy
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      – SubjectFull: Orbital Cellulitis
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      – TitleFull: Orbital lymphoma presenting as preseptal cellulitis in a child with ataxia-telangiectasia.
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              Text: 2026 Sep 17
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