Academic Journal
Transcriptome-based classification in mice with ASD-risk mutations.
| Τίτλος: | Transcriptome-based classification in mice with ASD-risk mutations. |
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| Συγγραφείς: | Roh JD; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Jun Y; Division of National Supercomputing, Korea Institute of Science and Technology Information (KISTI), Daejeon, Korea., Jeon H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Yi Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Kim M; Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Cho H; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Oh Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Moon H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Kim J; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Kim S; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Ryu J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Kang M; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Kim Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Jung Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Yoo T; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Oh H; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Kim H; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Jin C; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Yang Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; Digital Omics Research Center, Korea Basic Science Institute (KBSI), Cheongju, Chungbuk, Korea., Choi G; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Korea., Ahn S; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Korea., Kim JY; Digital Omics Research Center, Korea Basic Science Institute (KBSI), Cheongju, Chungbuk, Korea., Kang H; Division of National Supercomputing, Korea Institute of Science and Technology Information (KISTI), Daejeon, Korea., Bae M; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea., Kim E; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. |
| Πηγή: | Science (New York, N.Y.) [Science] 2026 Sep 17; Vol. 393 (6817), pp. 1250-1257. Date of Electronic Publication: 2026 Sep 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| Ιατρικοί όροι (MeSH): | Autism Spectrum Disorder*/genetics , Single-Cell Gene Expression Analysis*/classification , Transcriptome*, Fluoxetine/pharmacology ; Prefrontal Cortex/metabolism ; Prefrontal Cortex/cytology ; Animals ; Female ; Male ; Mice ; Disease Models, Animal ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Mutation ; RNA-Seq ; Atlases as Topic ; Animals, Genetically Modified ; Mice, Mutant Strains |
| Περίληψη: | Autism spectrum disorder (ASD) is a neurodevelopmental condition with a strong genetic component. Large-scale human genetic studies have identified >1200 ASD-risk genes. We report a sex-balanced atlas of 1008 prefrontal RNA sequencing (RNA-seq) profiles from 17 mouse lines carrying ASD-risk mutations. Our analysis identified two opposing transcriptomic states. The two groups differed in sex bias, regional specificity, developmental stability, cell type remodeling, and responses to fluoxetine and lithium. Single-nucleus RNA-seq revealed broader cell type remodeling in group 1 than in group 2, and cell type-specific modules showed reciprocal associations that mirrored bulk transcriptomic signatures. The framework classifies independent mouse lines and identifies subgroups with conserved synaptic directionality, supporting molecular stratification. |
| Σχόλια: | Comment in: Science. 2026 Sep 17;393(6817):1188-1189. doi: 10.1126/science.ael3062.. (PMID: 42752156) |
| Substance Nomenclature: | 01K63SUP8D (Fluoxetine) |
| Entry Date(s): | Date Created: 20260917 Date Completed: 20260917 Latest Revision: 20260921 |
| Update Code: | 20260921 |
| DOI: | 10.1126/science.adz6688 |
| PMID: | 42752124 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adz6688 |