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Integrated Fe(III)-driven liquid-phase microextraction-spectrophotometry for selective and high-throughput detection of ethyl maltol in complex food samples.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Integrated Fe(III)-driven liquid-phase microextraction-spectrophotometry for selective and high-throughput detection of ethyl maltol in complex food samples.
Συγγραφείς: Qi J; Affiliated Central Hospital of Huanghuai University, Zhumadian, 463000, China.; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.; China Meheco Topfond Pharmaceutical Co., Ltd., Zhumadian, 463000, China., Liu J; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Hu C; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Wang Q; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Guo Y; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Zhang M; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Hu L; School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China., Lin B; Key Laboratory of Food Safety Risk Monitoring for Health Commission of Hubei Province, Huanggang Municipal Center for Disease Control and Prevention, Huanggang, 438000, China. linbin0722@126.com., Li W; Affiliated Central Hospital of Huanghuai University, Zhumadian, 463000, China. zcr3817202@163.com.
Πηγή: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2026 Sep 16. Date of Electronic Publication: 2026 Sep 16.
Publication Model: Ahead of Print
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE
Imprint Name(s): Original Publication: Heidelberg : Springer-Verlag, 2002-
Περίληψη: Excessive addition of ethyl maltol (EMA) to foods poses potential health risks, highlighting the need for reliable monitoring. Herein, an integrated Fe(III)-driven liquid-phase microextraction (LPME)-spectrophotometry system was developed for selective and high-throughput EMA determination. Fe(III) in the acceptor phase served dual roles: as a chemical trap achieving >90% extraction efficiency and as an in situ chromogenic probe enabling direct detection. This unique design combines membrane-mediated matrix exclusion with coordination-assisted extraction, resulting in enhanced sensitivity and improved resistance to matrix interference. Density functional theory calculations revealed that Fe(III) facilitated the forward extraction by reducing the transmembrane transfer free energy barrier while suppressing back-extraction via weakening EMA-membrane solvent interactions. Under the evaluated conditions, the system offered a broad linear range (7.8-1500 μM, R2 > 0.999), low detection limit (0.67 μM), and satisfactory selectivity toward structural analogues. Validation in diverse food matrices yielded recoveries of 88-107% with good agreement with HPLC-UV (R2 > 0.99). The minimal solvent consumption, high throughput, and favorable greenness further highlight its practical utility. More than an EMA detection method, this work provides a proof-of-concept for the coordination-driven LPME strategy that intrinsically integrates sample preparation with in situ signal generation, offering new insights into the design of a mechanism-driven microextraction system.
(© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.)
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
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Grant Information: 262102321126 the Science and Technology Research Project of Henan Province, China; 252102321121 the Science and Technology Research Project of Henan Province, China; 2025AFB453 Natural Science Foundation of Hubei Province; 2022A03J00108 the Science and Technology Program of Guangzhou; ZMDSKJGG2024008 the Science and Technology Research Project in the Social Development of Zhumadian, China; 231111320300 the Key Research and Development Program of Henan Province, China; 26B430015 the Key Scientific Research Projects of Henan Provincial Higher Education Institutions
Contributed Indexing: Keywords: Coordination-driven extraction; Ethyl maltol; Food analysis; Liquid-phase microextraction; Spectrophotometry
Entry Date(s): Date Created: 20260916 Latest Revision: 20260916
Update Code: 20260917
DOI: 10.1007/s00216-026-06819-1
PMID: 42749818
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1618-2650
DOI:10.1007/s00216-026-06819-1