Academic Journal
Efficacy of different isoxazolines against natural Psoroptes cuniculi infestation in rabbits.
| Τίτλος: | Efficacy of different isoxazolines against natural Psoroptes cuniculi infestation in rabbits. |
|---|---|
| Συγγραφείς: | Machado MA; Graduate Program in Veterinary Sciences, Department of Animal Parasitology, Institute of Veterinary, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Azevedo AGH; Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Campos DR; Department of Animal Parasitology, Institute of Veterinary, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil. Electronic address: diefrey8@gmail.com., Borges DA; Graduate Program in Veterinary Sciences, Department of Animal Parasitology, Institute of Veterinary, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Scott FB; Department of Animal Parasitology, Institute of Veterinary, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil., Fernandes JI; Department of Veterinary Medicine and Surgery, Institute of Veterinary, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil. |
| Πηγή: | Experimental parasitology [Exp Parasitol] 2026 Oct; Vol. 289, pp. 109202. Date of Electronic Publication: 2026 Sep 16. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Orlando, FL : Academic Press Original Publication: New York. |
| Ιατρικοί όροι (MeSH): | Psoroptidae*/drug effects , Mite Infestations*/drug therapy , Mite Infestations*/veterinary , Mite Infestations*/parasitology , Isoxazoles*/therapeutic use , Isoxazoles*/pharmacology , Isoxazoles*/administration & dosage , Acaricides*/therapeutic use , Acaricides*/administration & dosage, Rabbits/parasitology ; Naphthalenes/therapeutic use ; Naphthalenes/administration & dosage ; Spiro Compounds/therapeutic use ; Animals ; Administration, Oral ; Female ; Male ; Random Allocation ; Azetidines |
| Περίληψη: | Psoroptic mange caused by Psoroptes cuniculi is an important parasitic dermatopathy in rabbits and is commonly associated with pruritus, accumulation of ceruminous exudate, crust formation, and inflammatory auricular lesions. Although several isoxazolines have demonstrated efficacy against mite infestations in companion animals, information regarding their use in rabbits remains limited. The present study evaluated the efficacy and safety of single-dose oral administration of afoxolaner, fluralaner, and sarolaner in rabbits naturally infested with P. cuniculi. Thirty-two New Zealand White rabbits were randomly allocated into four experimental groups (n = 8/group): untreated control, afoxolaner (2.5 mg/kg), fluralaner (25 mg/kg), or sarolaner (2 mg/kg). Parasitological and clinical evaluations were performed on Days 0, +3, +7, +14, +21, +28, and +35. Rabbits treated with afoxolaner and fluralaner achieved complete parasitological cure from Day +3 onwards, while those treated with sarolaner reached complete parasitological cure on Day +7. No significant differences in parasitological cure rates were observed among the treated groups after treatment (P > 0.05). All treated groups showed progressive clinical improvement throughout the study period. No adverse effects were observed following treatment administration. In contrast, rabbits from the untreated control group remained positive and showed persistence of clinical lesions throughout the experimental period. Under the conditions of this study, single-dose oral administration of afoxolaner, fluralaner, and sarolaner demonstrated therapeutic efficacy against natural P. cuniculi infestation in rabbits, supporting the potential use of isoxazolines for the treatment of psoroptic mange in this species. (Copyright © 2026. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Afoxolaner; Fluralaner; Psoroptic mange; Sarolaner; Treatment |
| Substance Nomenclature: | 0 (Isoxazoles) 02L07H6D0U (afoxolaner) 0 (sarolaner) 0 (Naphthalenes) 0 (Acaricides) 0 (Spiro Compounds) 0 (A1443 compound) 0 (Azetidines) |
| Entry Date(s): | Date Created: 20260916 Date Completed: 20261007 Latest Revision: 20261007 |
| Update Code: | 20261008 |
| DOI: | 10.1016/j.exppara.2026.109202 |
| PMID: | 42749038 |
| Βάση Δεδομένων: | MEDLINE |
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