Academic Journal
Pulse width-dependent Monte Carlo source modeling for ultra-high dose rate electron beams.
| Τίτλος: | Pulse width-dependent Monte Carlo source modeling for ultra-high dose rate electron beams. |
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| Συγγραφείς: | Henao Isaza Á; Institute of Microelectronics of Barcelona, IMB-CNM (CSIC), Carrer dels Til.lers s/n, 08193, Cerdanyola del Vallés (Bellaterra), Barcelona, Spain., López Paz I; Institute of Microelectronics of Barcelona, IMB-CNM (CSIC), Carrer dels Til.lers s/n, 08193, Cerdanyola del Vallés (Bellaterra), Barcelona, Spain., Guardiola C; Institute of Microelectronics of Barcelona, IMB-CNM (CSIC), Carrer dels Til.lers s/n, 08193, Cerdanyola del Vallés (Bellaterra), Barcelona, Spain., Sebastián Moreno J; Institut Curie, Inserm U1353-CNRS UMR9029, University Versailles Saint-Quentin, PSL Research University, 91405 Orsay, France.; Physics Department, National University of Colombia, Cuidad Universitaria, 11321 Bogotá, Colombia., Heinrich S; Institut Curie, Inserm U1353-CNRS UMR9029, University Versailles Saint-Quentin, PSL Research University, 91405 Orsay, France. |
| Πηγή: | Physics in medicine and biology [Phys Med Biol] 2026 Oct 01; Vol. 71 (19). Date of Electronic Publication: 2026 Oct 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol : IOP Publishing |
| Ιατρικοί όροι (MeSH): | Electrons*/therapeutic use , Monte Carlo Method* , Radiation Dosage*, Animals ; Mice ; Radiotherapy Dosage |
| Περίληψη: | Objective.The emergence of ultra-high dose rate (UHDR) electron beams has highlighted the need for accurate Monte Carlo (MC) source models after recent measurements revealed pulse width (PW)-dependent discrepancies in dose profiles. This work aims to develop and validate a MC source model for conventional and FLASH modes using GATE 10, including PW dependence.Approach.Percentage depth dose (PDD) curves and lateral dose profiles were measured in water using a flashDiamond detector for PWs of 0.5-5s. These data were used to optimize the parametric source model throughminimization and gamma analysis. Validation was performed using a mouse collimator and PMMA slabs. Relative dose distributions and cumulative dose-volume histograms were computed in a CT-based voxelised mouse, with and without bolus.Main results.The optimized FLASH source model features a dual-peak energy spectrum with a PW-dependent energy component (7.0-7.8 MeV for 0.5-5s) and low-energy component probability. In conventional mode, a two-component spectrum (1.51.0 and 6.81.5 MeV) was used. Simulations showed good agreement with measurements (gamma-index 2 mm/2% anddifferences for,and). Differences in the mouse lung volume receiving at least 95% of the maximum dose (V95) were 1% across FLASH PWs, increasing to 5% and 12% in CONV without and with bolus, respectively. Bolus increased V95in FLASH by 17%, indicating improved target coverage.Significance.A GATE 10 MC-based source model of the ElectronFLASH LINAC was developed for both UHDR (PW-dependent) and conventional modes. Despite PW-dependent energy variations, no significant dosimetric differences were observed between PWs in FLASH in the preclinical mouse model. The model provides a reliable tool for optimization of preclinical irradiation setups for FLASH biological studies in the absence of a treatment planning system. (Creative Commons Attribution license.) |
| Contributed Indexing: | Keywords: FLASH electron linac; FLASH-RT; GATE; dosimetry |
| Entry Date(s): | Date Created: 20260916 Date Completed: 20261001 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| DOI: | 10.1088/1361-6560/aea8c4 |
| PMID: | 42748957 |
| Βάση Δεδομένων: | MEDLINE |
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