Academic Journal
Altered network homogeneity of the default mode network in patients with tension-type headache.
| Τίτλος: | Altered network homogeneity of the default mode network in patients with tension-type headache. |
|---|---|
| Συγγραφείς: | Yin H; Department of Neurology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Guo X; Department of Neurology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Gao Y; Department of Psychiatry, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan University of Science and Technology, Wuhan, Hubei, China., Zhou Q; Department of Neurology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Min P; Department of Medical Imaging, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Xia M; Department of Medical Imaging, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Peng X; Department of Medical Imaging, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Chen L; Department of Medical Imaging, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Wang Y; Department of Medical Imaging, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China., Han Q; Department of Neurology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China. |
| Πηγή: | Frontiers in neurology [Front Neurol] 2026 Sep 01; Vol. 17, pp. 1870552. Date of Electronic Publication: 2026 Sep 01 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-2295 (Electronic) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation, 2010]- |
| Ιατρικοί όροι (MeSH): | Tension-Type Headache*/physiopathology , Tension-Type Headache*/diagnostic imaging , Default Mode Network*/physiopathology , Default Mode Network*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging, Humans ; Female ; Adult ; Male ; Magnetic Resonance Imaging ; Young Adult ; Brain Mapping ; Support Vector Machine ; Middle Aged |
| Περίληψη: | Objective: Dysfunction of the default mode network (DMN) is strongly linked to pain processing, as well as onset and progression of chronic pain disorders; however, its specific role in the pathogenesis of tension-type headache (TTH) remains incompletely understood. This study aims to explore the network homogeneity (NH) of the DMN in the pathophysiological mechanisms underlying TTH. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and clinical headache scale assessments were conducted on 68 patients with TTH and 63 healthy controls (HCs). Independent component analysis and NH analysis were used to evaluate the neuroimaging data. Results: Patients with TTH exhibited decreased NH values in the right posterior cingulate cortex (PCC) and increased NH values in the right medial superior frontal gyrus (SFGmed), bilateral angular gyrus (AG), and left precuneus (PCu), compared to HCs. Additionally, the NH values of right AG, left AG and right PCC were positively correlated with Headache Impact Test-6 (HIT-6), Migraine Disability Assessment Test (MIDAS) scores and headache intensity. Furthermore, support vector machine (SVM) analysis revealed that NH values in the right PCC could distinguish TTH patients from HCs with an accuracy of 75.57%, sensitivity of 84.13%, specificity of 70.59%, and an AUC of 0.7156. Conclusion: This study demonstrates altered network homogeneity (NH) within the DMN in patients with TTH. Furthermore, the NH value of the right PCC showed discriminative potential to distinguish TTH patients from healthy controls via SVM classification. (Copyright © 2026 Yin, Guo, Gao, Zhou, Min, Xia, Peng, Chen, Wang and Han.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| References: | Front Mol Neurosci. 2022 Sep 14;15:967103. (PMID: 36187356) Neuroimage. 2011 Apr 15;55(4):1497-503. (PMID: 21134472) Pain Pract. 2014 Sep;14(7):625-31. (PMID: 24237583) J Headache Pain. 2025 Mar 10;26(1):49. (PMID: 40065229) Neuron. 2023 Aug 16;111(16):2469-2487. (PMID: 37167968) Front Syst Neurosci. 2010 May 14;4:13. (PMID: 20577591) Front Neurosci. 2023 Apr 11;17:1096232. (PMID: 37113158) J Headache Pain. 2020 Nov 23;21(1):135. (PMID: 33228537) Neuroimage Clin. 2017 Oct 19;17:222-231. (PMID: 29159039) Neuroimage. 2020 Aug 1;216:116877. (PMID: 32344063) Cephalalgia. 2018 Jan;38(1):1-211. (PMID: 29368949) Brain Struct Funct. 2023 Jan;228(1):1-5. (PMID: 36369274) Front Neurol. 2021 Nov 29;12:751400. (PMID: 34912284) Front Neurosci. 2022 Mar 07;16:825172. (PMID: 35345545) Hum Brain Mapp. 2016 Jul;37(7):2630-44. (PMID: 27104478) Int J Psychophysiol. 2017 Feb;112:46-51. (PMID: 27989405) Nat Rev Neurosci. 2021 Aug;22(8):503-513. (PMID: 34226715) J Neurosci Methods. 2008 Mar 30;169(1):249-54. (PMID: 18190970) Neural Plast. 2023 May 24;2023:6560298. (PMID: 37266410) Neuroimage. 2013 Sep;78:46-58. (PMID: 23587692) BMC Med Imaging. 2025 May 1;25(1):145. (PMID: 40312692) J Neurosci Res. 2025 Jun;103(6):e70057. (PMID: 40519127) Neuroreport. 2016 Mar 2;27(4):257-63. (PMID: 26825347) Front Neurosci. 2022 Oct 18;16:905942. (PMID: 36330349) Neuroscience. 2022 Apr 1;487:198-206. (PMID: 35158018) Front Neurosci. 2021 Mar 04;15:646538. (PMID: 33746709) J Affect Disord. 2023 Oct 15;339:486-494. (PMID: 37437732) Pain. 2014 Dec;155(12):2491-2501. (PMID: 25047783) Neuroimage. 2005 Sep;27(3):520-32. (PMID: 15946864) Mol Neurobiol. 2019 Feb;56(2):1137-1166. (PMID: 29876878) Am J Phys Med Rehabil. 2017 Apr;96(4):253-259. (PMID: 28301866) Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82. (PMID: 11209064) Brain Res Bull. 2025 Dec;233:111653. (PMID: 41297797) Neurosci Res. 2024 Dec;209:9-17. (PMID: 38160734) J Neurosci. 2014 Jan 15;34(3):932-40. (PMID: 24431451) Annu Rev Neurosci. 2015 Jul 8;38:433-47. (PMID: 25938726) Arthritis Rheum. 2010 Aug;62(8):2545-55. (PMID: 20506181) Neurosci Biobehav Rev. 2024 Sep;164:105839. (PMID: 39097251) Biomed Res Int. 2014;2014:978064. (PMID: 24527462) Cephalalgia. 2018 Apr;38(5):846-854. (PMID: 28605972) Front Psychiatry. 2022 Jun 17;13:877956. (PMID: 35782421) Front Neurol. 2023 Jan 30;13:1105592. (PMID: 36793799) Neurosci Bull. 2014 Dec;30(6):949-955. (PMID: 25098351) Rev Neurosci. 2023 Jun 08;34(8):899-914. (PMID: 37288945) Hum Brain Mapp. 2023 Feb 1;44(2):571-584. (PMID: 36129066) Neuroimage. 2012 Jan 16;59(2):1420-8. (PMID: 21889994) J Affect Disord. 2023 Jul 1;332:136-142. (PMID: 36990286) Headache. 2025 Jul-Aug;65(7):1160-1169. (PMID: 40391553) Front Psychiatry. 2022 Aug 25;13:949512. (PMID: 36090354) J Headache Pain. 2020 May 6;21(1):47. (PMID: 32375638) Brain Behav. 2025 Mar;15(3):e70414. (PMID: 40079637) J Pain Res. 2019 May 29;12:1743-1755. (PMID: 31213886) J Headache Pain. 2016 Dec;17(1):98. (PMID: 27771875) J Headache Pain. 2017 Aug 23;18(1):89. (PMID: 28831711) J Neurosci. 2008 Feb 6;28(6):1398-403. (PMID: 18256259) Neurology. 2005 Nov 8;65(9):1483-6. (PMID: 16275843) J Headache Pain. 2021 Oct 28;22(1):129. (PMID: 34711175) Neural Plast. 2021 Apr 26;2021:6653309. (PMID: 33995525) Science. 1988 Jun 3;240(4857):1285-93. (PMID: 3287615) J Integr Neurosci. 2024 Jan 22;23(1):19. (PMID: 38287847) |
| Contributed Indexing: | Keywords: default mode network; network homogeneity; resting-state functional magnetic resonance; support vector machine; tension-type headache |
| Entry Date(s): | Date Created: 20260916 Date Completed: 20260916 Latest Revision: 20260917 |
| Update Code: | 20260917 |
| PubMed Central ID: | PMC13574691 |
| DOI: | 10.3389/fneur.2026.1870552 |
| PMID: | 42745836 |
| Βάση Δεδομένων: | MEDLINE |
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