Academic Journal
Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.
| Τίτλος: | Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation. |
|---|---|
| Συγγραφείς: | Alves ACRC; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., da Silva AA; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., da Silva RB; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Lima França R; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Romão DA; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Fragoso; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Dos Santos NB; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Porto; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil. |
| Πηγή: | Clinical and experimental dental research [Clin Exp Dent Res] 2026 Oct; Vol. 12 (5), pp. e70449. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 101692332 Publication Model: Print Cited Medium: Internet ISSN: 2057-4347 (Electronic) Linking ISSN: 20574347 NLM ISO Abbreviation: Clin Exp Dent Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hoboken : Wiley, [2015]- |
| Ιατρικοί όροι (MeSH): | Dentin*/drug effects , Dentin*/enzymology , Quercetin*/pharmacology , Quercetin*/chemistry , Dental Bonding*/methods , Polyphenols*/pharmacology , Polyphenols*/chemistry , Dentin-Bonding Agents*/chemistry, Resveratrol/pharmacology ; Tensile Strength/drug effects ; Chlorhexidine/pharmacology ; Chlorhexidine/chemistry ; Collagenases/metabolism ; Antioxidants/pharmacology ; Collagen/metabolism ; Collagen/drug effects ; Resin Cements/chemistry ; Humans ; Materials Testing ; Bisphenol A-Glycidyl Methacrylate |
| Περίληψη: | Introduction: Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures. Objectives: This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation. Materials and Methods: Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey's test (p < 0.05). Results: Quercetin-treated specimens showed a significant weight increase compared with CHX (p < 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p > 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001). Conclusions: Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations. (© 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.) |
| References: | J Dent Res. 2011 Aug;90(8):953-68. (PMID: 21220360) J Clin Exp Dent. 2025 Jun 1;17(6):e665-e674. (PMID: 40621134) Molecules. 2024 Feb 25;29(5):. (PMID: 38474512) Eur J Oral Sci. 2018 Apr;126(2):146-158. (PMID: 29380895) Dent Mater. 2017 Feb;33(2):133-143. (PMID: 28007396) Int J Dent. 2026 Aug 10;2026:6925650. (PMID: 42577680) Dent Mater. 2021 Dec;37(12):1794-1805. (PMID: 34579958) Caries Res. 2019;53(1):107-117. (PMID: 30021200) Dent Mater. 2019 Feb;35(2):328-334. (PMID: 30580969) Food Chem. 2017 Nov 1;234:479-485. (PMID: 28551264) Caries Res. 2024;58(6):562-572. (PMID: 38815561) J Dent. 2014 Sep;42(9):1178-84. (PMID: 25010542) J Med Food. 2019 Aug;22(8):753-770. (PMID: 31084513) Acta Biomater. 2012 Jul;8(7):2419-33. (PMID: 22414619) J Istanb Univ Fac Dent. 2015 Apr 29;49(2):1-7. (PMID: 28955529) Med Sci Monit. 2018 Apr 27;24:2583-2589. (PMID: 29701200) J Dent Res. 2014 Aug;93(8):733-43. (PMID: 24935066) Free Radic Biol Med. 2019 Nov 1;143:240-251. (PMID: 31381971) Drug Discov Today. 2016 Apr;21(4):632-9. (PMID: 26905599) J Microbiol Biotechnol. 2020 Jan 28;30(1):11-20. (PMID: 31752056) Food Chem Toxicol. 2017 Oct;108(Pt B):365-374. (PMID: 27591927) Trends Food Sci Technol. 2019 Sep;91:586-597. (PMID: 32288229) J Biomed Mater Res. 1982 May;16(3):265-73. (PMID: 7085687) Dent Mater. 2018 Jan;34(1):78-96. (PMID: 29179971) Molecules. 2021 Jan 05;26(1):. (PMID: 33466247) Tissue Eng Regen Med. 2022 Aug;19(4):887-889. (PMID: 35594009) Langmuir. 2014 Dec 16;30(49):14887-93. (PMID: 25379878) Antioxidants (Basel). 2019 Mar 18;8(3):. (PMID: 30889815) Heliyon. 2020 Apr 28;6(4):e03871. (PMID: 32373750) Curr Pharm Biotechnol. 2022;23(7):1009-1018. (PMID: 34132179) Dent Mater. 2021 Jul;37(7):1083-1095. (PMID: 33863568) Phytomedicine. 2021 Nov;92:153736. (PMID: 34560520) Acta Biomater. 2014 Jul;10(7):3288-94. (PMID: 24721612) Pharmacol Res. 2017 Oct;124:126-145. (PMID: 28803136) Dent Mater. 2022 Dec;38(12):e297-e307. (PMID: 36192276) Int J Clin Exp Med. 2015 Jul 15;8(7):10793-803. (PMID: 26379873) Food Chem. 2022 Feb 1;369:130918. (PMID: 34455318) |
| Grant Information: | 00x0ma614 Coordination for the Improvement of Higher Education Personnel - CAPES |
| Contributed Indexing: | Keywords: collagen; dentin; polyphenols; quercetin; resveratrol |
| Substance Nomenclature: | Q369O8926L (Resveratrol) 9IKM0I5T1E (Quercetin) R4KO0DY52L (Chlorhexidine) EC 3.4.24.- (Collagenases) 0 (Polyphenols) 0 (Dentin-Bonding Agents) 0 (Antioxidants) 9007-34-5 (Collagen) 0 (single bond) 0 (Resin Cements) 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate) |
| Entry Date(s): | Date Created: 20260915 Date Completed: 20260915 Latest Revision: 20260917 |
| Update Code: | 20260917 |
| PubMed Central ID: | PMC13577594 |
| DOI: | 10.1002/cre2.70449 |
| PMID: | 42743388 |
| Βάση Δεδομένων: | MEDLINE |
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