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Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.

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Τίτλος: Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.
Συγγραφείς: Alves ACRC; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., da Silva AA; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., da Silva RB; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Lima França R; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Romão DA; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Fragoso; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., Dos Santos NB; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., de Porto; Faculty of Dentistry, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
Πηγή: Clinical and experimental dental research [Clin Exp Dent Res] 2026 Oct; Vol. 12 (5), pp. e70449.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 101692332 Publication Model: Print Cited Medium: Internet ISSN: 2057-4347 (Electronic) Linking ISSN: 20574347 NLM ISO Abbreviation: Clin Exp Dent Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Hoboken : Wiley, [2015]-
Ιατρικοί όροι (MeSH): Dentin*/drug effects , Dentin*/enzymology , Quercetin*/pharmacology , Quercetin*/chemistry , Dental Bonding*/methods , Polyphenols*/pharmacology , Polyphenols*/chemistry , Dentin-Bonding Agents*/chemistry, Resveratrol/pharmacology ; Tensile Strength/drug effects ; Chlorhexidine/pharmacology ; Chlorhexidine/chemistry ; Collagenases/metabolism ; Antioxidants/pharmacology ; Collagen/metabolism ; Collagen/drug effects ; Resin Cements/chemistry ; Humans ; Materials Testing ; Bisphenol A-Glycidyl Methacrylate
Περίληψη: Introduction: Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.
Objectives: This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.
Materials and Methods: Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey's test (p < 0.05).
Results: Quercetin-treated specimens showed a significant weight increase compared with CHX (p < 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p > 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001).
Conclusions: Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.
(© 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.)
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Int J Dent. 2026 Aug 10;2026:6925650. (PMID: 42577680)
Dent Mater. 2021 Dec;37(12):1794-1805. (PMID: 34579958)
Caries Res. 2019;53(1):107-117. (PMID: 30021200)
Dent Mater. 2019 Feb;35(2):328-334. (PMID: 30580969)
Food Chem. 2017 Nov 1;234:479-485. (PMID: 28551264)
Caries Res. 2024;58(6):562-572. (PMID: 38815561)
J Dent. 2014 Sep;42(9):1178-84. (PMID: 25010542)
J Med Food. 2019 Aug;22(8):753-770. (PMID: 31084513)
Acta Biomater. 2012 Jul;8(7):2419-33. (PMID: 22414619)
J Istanb Univ Fac Dent. 2015 Apr 29;49(2):1-7. (PMID: 28955529)
Med Sci Monit. 2018 Apr 27;24:2583-2589. (PMID: 29701200)
J Dent Res. 2014 Aug;93(8):733-43. (PMID: 24935066)
Free Radic Biol Med. 2019 Nov 1;143:240-251. (PMID: 31381971)
Drug Discov Today. 2016 Apr;21(4):632-9. (PMID: 26905599)
J Microbiol Biotechnol. 2020 Jan 28;30(1):11-20. (PMID: 31752056)
Food Chem Toxicol. 2017 Oct;108(Pt B):365-374. (PMID: 27591927)
Trends Food Sci Technol. 2019 Sep;91:586-597. (PMID: 32288229)
J Biomed Mater Res. 1982 May;16(3):265-73. (PMID: 7085687)
Dent Mater. 2018 Jan;34(1):78-96. (PMID: 29179971)
Molecules. 2021 Jan 05;26(1):. (PMID: 33466247)
Tissue Eng Regen Med. 2022 Aug;19(4):887-889. (PMID: 35594009)
Langmuir. 2014 Dec 16;30(49):14887-93. (PMID: 25379878)
Antioxidants (Basel). 2019 Mar 18;8(3):. (PMID: 30889815)
Heliyon. 2020 Apr 28;6(4):e03871. (PMID: 32373750)
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Grant Information: 00x0ma614 Coordination for the Improvement of Higher Education Personnel - CAPES
Contributed Indexing: Keywords: collagen; dentin; polyphenols; quercetin; resveratrol
Substance Nomenclature: Q369O8926L (Resveratrol)
9IKM0I5T1E (Quercetin)
R4KO0DY52L (Chlorhexidine)
EC 3.4.24.- (Collagenases)
0 (Polyphenols)
0 (Dentin-Bonding Agents)
0 (Antioxidants)
9007-34-5 (Collagen)
0 (single bond)
0 (Resin Cements)
454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
Entry Date(s): Date Created: 20260915 Date Completed: 20260915 Latest Revision: 20260917
Update Code: 20260917
PubMed Central ID: PMC13577594
DOI: 10.1002/cre2.70449
PMID: 42743388
Βάση Δεδομένων: MEDLINE
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  Data: Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures.&lt;br /&gt;Objectives: This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation.&lt;br /&gt;Materials and Methods: Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 &#181;g/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37&#176;C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey&#39;s test (p &amp;lt; 0.05).&lt;br /&gt;Results: Quercetin-treated specimens showed a significant weight increase compared with CHX (p &amp;lt; 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p &amp;gt; 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001).&lt;br /&gt;Conclusions: Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.&lt;br /&gt; (&#169; 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley &amp; Sons Ltd.)
– Name: Ref
  Label: References
  Group: RefInfo
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– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: 00x0ma614 Coordination for the Improvement of Higher Education Personnel - CAPES
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;collagen; dentin; polyphenols; quercetin; resveratrol
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: Q369O8926L (Resveratrol)&lt;br /&gt;9IKM0I5T1E (Quercetin)&lt;br /&gt;R4KO0DY52L (Chlorhexidine)&lt;br /&gt;EC 3.4.24.- (Collagenases)&lt;br /&gt;0 (Polyphenols)&lt;br /&gt;0 (Dentin-Bonding Agents)&lt;br /&gt;0 (Antioxidants)&lt;br /&gt;9007-34-5 (Collagen)&lt;br /&gt;0 (single bond)&lt;br /&gt;0 (Resin Cements)&lt;br /&gt;454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260915 &lt;i&gt;Date Completed: &lt;/i&gt;20260915 &lt;i&gt;Latest Revision: &lt;/i&gt;20260917
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260917
– Name: PubmedCentralID
  Label: PubMed Central ID
  Group: ID
  Data: PMC13577594
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1002/cre2.70449
– Name: AN
  Label: PMID
  Group: ID
  Data: 42743388
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42743388
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/cre2.70449
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e70449
    Subjects:
      – SubjectFull: Resveratrol pharmacology
        Type: general
      – SubjectFull: Tensile Strength drug effects
        Type: general
      – SubjectFull: Chlorhexidine pharmacology
        Type: general
      – SubjectFull: Chlorhexidine chemistry
        Type: general
      – SubjectFull: Collagenases metabolism
        Type: general
      – SubjectFull: Antioxidants pharmacology
        Type: general
      – SubjectFull: Collagen metabolism
        Type: general
      – SubjectFull: Collagen drug effects
        Type: general
      – SubjectFull: Resin Cements chemistry
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Materials Testing
        Type: general
      – SubjectFull: Bisphenol A-Glycidyl Methacrylate
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin enzymology
        Type: general
      – SubjectFull: Quercetin pharmacology
        Type: general
      – SubjectFull: Quercetin chemistry
        Type: general
      – SubjectFull: Dental Bonding methods
        Type: general
      – SubjectFull: Polyphenols pharmacology
        Type: general
      – SubjectFull: Polyphenols chemistry
        Type: general
      – SubjectFull: Dentin-Bonding Agents chemistry
        Type: general
    Titles:
      – TitleFull: Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.
        Type: main
  BibRelationships:
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            NameFull: Alves ACRC
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            NameFull: da Silva AA
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            NameFull: da Silva RB
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            NameFull: de Lima França R
      – PersonEntity:
          Name:
            NameFull: Romão DA
      – PersonEntity:
          Name:
            NameFull: de Fragoso
      – PersonEntity:
          Name:
            NameFull: Dos Santos NB
      – PersonEntity:
          Name:
            NameFull: de Porto
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      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2057-4347
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Clinical and experimental dental research
              Type: main
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