Academic Journal
Sourdough Bread and Baker's Yeast Bread Affect Gut Symptoms and Targeted Gut Microbial Taxa Differently: A Randomised Controlled Trial.
| Τίτλος: | Sourdough Bread and Baker's Yeast Bread Affect Gut Symptoms and Targeted Gut Microbial Taxa Differently: A Randomised Controlled Trial. |
|---|---|
| Συγγραφείς: | Watters SIN; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway., Henriksen C; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway., Gjøvik M; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway., Garnweidner-Holme L; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway., Frederiksen MP; Mesterbakeren AS, 0552 Oslo, Norway., Jonassen S; Mesterbakeren AS, 0552 Oslo, Norway., Ravnanger I; Mesterbakeren AS, 0552 Oslo, Norway., Myhrstad MCW; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway., Telle-Hansen VH; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.; Intelligent Health, Faculty of Health Sciences and Faculty of Technology, Art and Design, Oslo Metropolitan University, 0130 Oslo, Norway. |
| Πηγή: | Nutrients [Nutrients] 2026 Sep 01; Vol. 18 (17). Date of Electronic Publication: 2026 Sep 01. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| Ιατρικοί όροι (MeSH): | Bread*/microbiology , Bread*/analysis , Saccharomyces cerevisiae* , Gastrointestinal Microbiome*, Feces/microbiology ; Diarrhea/microbiology ; Humans ; Cross-Over Studies ; Double-Blind Method ; Male ; Adult ; Female ; Triticum ; Middle Aged |
| Περίληψη: | Background/Objectives: The intake of bread has been associated with gastrointestinal discomfort in some individuals. The primary aim of this study was to investigate gut symptoms upon consuming sourdough bread compared to baker's yeast bread. Secondary endpoints were changes in targeted gut microbial taxa, micronutrient levels, and metabolic markers. Methods: This randomised, controlled, double-blind cross-over study included twenty healthy participants. Sourdough or baker's yeast bread was consumed for one week before crossing over. Before and after the interventions, participants reported gut symptoms, and they also provided blood samples to analyse micronutrients, metabolic markers, and faecal samples for targeted gut microbial taxa analyses. Results: The breads were made of whole grain wheat with similar macronutrients content. The sourdough bread contained less fructose than the baker's yeast bread. The consumption of sourdough bread caused a significant reduction in the diarrhoea sub-dimension score (p = 0.016) and a borderline significant reduction in the overall GSRS-IBS score compared to baker's yeast (p = 0.051). Several gut bacteria were significantly increased after intake of sourdough bread compared to baker's yeast bread: Alistipes putredinis (p = 0.029), Alistipes shahii (p = 0.015), Bifidobacterium adolescentis (p = 0.042), Bifidobacterium longum (p = 0.010) and Bifidobacterium longum subspecies longum (p = 0.021). There was a significant correlation between changes in diarrhoea score and changes in Alistipes shahii (r= -0.353, p = 0.025). Conclusions: This exploratory cross-over study did not demonstrate a statistically significant difference in the overall GSRS-IBS score between the two breads. A nominal difference in the diarrhoea sub-dimension and selected targeted microbial taxa was observed between the two breads, but these findings require further investigations. |
| References: | Am J Gastroenterol. 2006 Jul;101(7):1581-90. (PMID: 16863564) Int J Food Sci Nutr. 2017 Dec;68(8):987-996. (PMID: 28391735) Foods. 2020 May 15;9(5):. (PMID: 32429251) Microorganisms. 2021 Mar 23;9(3):. (PMID: 33806783) mSystems. 2025 Mar 18;10(3):e0160724. (PMID: 39936902) Nature. 2019 May;569(7758):655-662. (PMID: 31142855) Indian J Gastroenterol. 2019 Oct;38(5):378-390. (PMID: 31802437) Nutrients. 2019 Aug 05;11(8):. (PMID: 31387262) Scand J Gastroenterol. 1997 Sep;32(9):920-4. (PMID: 9299672) Front Microbiol. 2016 Jun 15;7:925. (PMID: 27379055) Med Hypotheses. 2015 Sep;85(3):295-7. (PMID: 26059250) Foods. 2019 Mar 09;8(3):. (PMID: 30857316) Aliment Pharmacol Ther. 2017 Aug;46(4):440-446. (PMID: 28627070) Nutrients. 2017 Nov 04;9(11):. (PMID: 29113045) BMC Nutr. 2019 Mar 06;5:12. (PMID: 32153925) J Nutr. 2018 Feb 1;148(2):202-208. (PMID: 29490103) Eur J Epidemiol. 2013 Nov;28(11):845-58. (PMID: 24158434) J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S104-6. (PMID: 15220671) Nutrients. 2018 Sep 06;10(9):. (PMID: 30200589) Gastroenterol Hepatol (N Y). 2019 Jan;15(1):16-26. (PMID: 30899204) Nat Rev Microbiol. 2019 Aug;17(8):497-511. (PMID: 31249397) Am J Clin Nutr. 2018 Jun 1;107(6):965-983. (PMID: 29757343) Br J Nutr. 2022 Feb 28;127(4):481-489. (PMID: 33818329) Front Microbiol. 2019 Jul 30;10:1733. (PMID: 31417524) Aliment Pharmacol Ther. 2016 Sep;44(5):460-70. (PMID: 27417338) Foods. 2018 Jun 22;7(7):. (PMID: 29932101) PLoS One. 2014 Oct 30;9(10):e111225. (PMID: 25356771) J Pediatr Gastroenterol Nutr. 2010 Dec;51(6):777-83. (PMID: 20975578) Lancet Diabetes Endocrinol. 2022 Jul;10(7):481-483. (PMID: 35662399) Food Nutr Res. 2022 Oct 21;66:. (PMID: 36340917) J Nutr. 2012 Aug;142(8):1510-8. (PMID: 22739368) Gut Microbes. 2017 Mar 4;8(2):172-184. (PMID: 28165863) Nat Rev Microbiol. 2013 Jul;11(7):497-504. (PMID: 23748339) Mol Nutr Food Res. 2017 Nov;61(11):. (PMID: 28730743) Int J Food Microbiol. 2018 Dec 2;286:55-65. (PMID: 30036730) Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502. (PMID: 28611480) Microorganisms. 2022 Jun 30;10(7):. (PMID: 35889049) Aliment Pharmacol Ther. 2005 Sep 1;22(5):387-94. (PMID: 16128676) Br J Nutr. 2008 Jan;99(1):110-20. (PMID: 17761020) Crit Rev Food Sci Nutr. 2024;64(22):8036-8053. (PMID: 37000015) Genome Announc. 2015 Apr 02;3(2):. (PMID: 25838473) Nutr Res Rev. 2017 Dec;30(2):149-190. (PMID: 28676135) Front Nutr. 2023 Jul 20;10:1230043. (PMID: 37545587) BMJ. 2016 Jun 14;353:i2716. (PMID: 27301975) Gut. 2015 Jan;64(1):93-100. (PMID: 25016597) Nutr J. 2010 Sep 15;9:37. (PMID: 20843361) Gastroenterology. 2005 Mar;128(3):541-51. (PMID: 15765388) Scand J Gastroenterol. 2003 Sep;38(9):947-54. (PMID: 14531531) ISME J. 2014 Nov;8(11):2218-30. (PMID: 24763370) J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:53-61. (PMID: 28244665) Cell Metab. 2017 Jun 6;25(6):1243-1253.e5. (PMID: 28591632) J Agric Food Chem. 2001 May;49(5):2657-62. (PMID: 11368651) Gut. 2017 Jul;66(7):1241-1251. (PMID: 26976734) Compr Rev Food Sci Food Saf. 2020 Nov;19(6):2862-2884. (PMID: 33337033) |
| Grant Information: | Regionale forskningsfond Oslofjordfondet; Forregion; Mesterbakeren; University of Oslo; OsloMet - Oslo Metropolitan University |
| Contributed Indexing: | Keywords: baker’s yeast bread; dietary fibre; fermentation; gut microbiota; sourdough bread; whole-grain |
| Entry Date(s): | Date Created: 20260915 Date Completed: 20260915 Latest Revision: 20260929 |
| Update Code: | 20260930 |
| PubMed Central ID: | PMC13567351 |
| DOI: | 10.3390/nu18172854 |
| PMID: | 42739025 |
| Βάση Δεδομένων: | MEDLINE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=20726643&ISBN=&volume=18&issue=17&date=20260901&spage=&pages=&title=Nutrients&atitle=Sourdough%20Bread%20and%20Baker%27s%20Yeast%20Bread%20Affect%20Gut%20Symptoms%20and%20Targeted%20Gut%20Microbial%20Taxa%20Differently%3A%20A%20Randomised%20Controlled%20Trial.&aulast=Watters%20SIN&id=DOI:10.3390/nu18172854 Name: Full Text Finder (for New FTF UI) (ns324271) Category: fullText Text: Full Text Finder MouseOverText: Full Text Finder |
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| Items | – Name: Title Label: Title Group: Ti Data: Sourdough Bread and Baker's Yeast Bread Affect Gut Symptoms and Targeted Gut Microbial Taxa Differently: A Randomised Controlled Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Watters+SIN%22">Watters SIN</searchLink>; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Henriksen+C%22">Henriksen C</searchLink>; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Gjøvik+M%22">Gjøvik M</searchLink>; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Garnweidner-Holme+L%22">Garnweidner-Holme L</searchLink>; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Frederiksen+MP%22">Frederiksen MP</searchLink>; Mesterbakeren AS, 0552 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Jonassen+S%22">Jonassen S</searchLink>; Mesterbakeren AS, 0552 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ravnanger+I%22">Ravnanger I</searchLink>; Mesterbakeren AS, 0552 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Myhrstad+MCW%22">Myhrstad MCW</searchLink>; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Telle-Hansen+VH%22">Telle-Hansen VH</searchLink>; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.; Intelligent Health, Faculty of Health Sciences and Faculty of Technology, Art and Design, Oslo Metropolitan University, 0130 Oslo, Norway. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101521595%22">Nutrients</searchLink> [Nutrients] 2026 Sep 01; Vol. 18 (17). <i>Date of Electronic Publication: </i>2026 Sep 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+Publishing%22">MDPI Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101521595 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2072-6643 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220726643%22">20726643 </searchLink><i>NLM ISO Abbreviation: </i>Nutrients <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: Basel, Switzerland : MDPI Publishing – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Bread%22">Bread*</searchLink>/<searchLink fieldCode="MM" term="%22Bread+microbiology%22">microbiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Bread%22">Bread*</searchLink>/<searchLink fieldCode="MM" term="%22Bread+analysis%22">analysis</searchLink> <br /><searchLink fieldCode="MM" term="%22Saccharomyces+cerevisiae%22">Saccharomyces cerevisiae*</searchLink> <br /><searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome%22">Gastrointestinal Microbiome*</searchLink><br /><searchLink fieldCode="MH" term="%22Feces%22">Feces</searchLink>/<searchLink fieldCode="MH" term="%22Feces+microbiology%22">microbiology</searchLink> ; <searchLink fieldCode="MH" term="%22Diarrhea%22">Diarrhea</searchLink>/<searchLink fieldCode="MH" term="%22Diarrhea+microbiology%22">microbiology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Cross-Over+Studies%22">Cross-Over Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Double-Blind+Method%22">Double-Blind Method</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Triticum%22">Triticum</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background/Objectives: The intake of bread has been associated with gastrointestinal discomfort in some individuals. The primary aim of this study was to investigate gut symptoms upon consuming sourdough bread compared to baker's yeast bread. Secondary endpoints were changes in targeted gut microbial taxa, micronutrient levels, and metabolic markers. Methods: This randomised, controlled, double-blind cross-over study included twenty healthy participants. Sourdough or baker's yeast bread was consumed for one week before crossing over. Before and after the interventions, participants reported gut symptoms, and they also provided blood samples to analyse micronutrients, metabolic markers, and faecal samples for targeted gut microbial taxa analyses. Results: The breads were made of whole grain wheat with similar macronutrients content. The sourdough bread contained less fructose than the baker's yeast bread. The consumption of sourdough bread caused a significant reduction in the diarrhoea sub-dimension score (p = 0.016) and a borderline significant reduction in the overall GSRS-IBS score compared to baker's yeast (p = 0.051). Several gut bacteria were significantly increased after intake of sourdough bread compared to baker's yeast bread: Alistipes putredinis (p = 0.029), Alistipes shahii (p = 0.015), Bifidobacterium adolescentis (p = 0.042), Bifidobacterium longum (p = 0.010) and Bifidobacterium longum subspecies longum (p = 0.021). There was a significant correlation between changes in diarrhoea score and changes in Alistipes shahii (r= -0.353, p = 0.025). Conclusions: This exploratory cross-over study did not demonstrate a statistically significant difference in the overall GSRS-IBS score between the two breads. A nominal difference in the diarrhoea sub-dimension and selected targeted microbial taxa was observed between the two breads, but these findings require further investigations. – Name: Ref Label: References Group: RefInfo Data: Am J Gastroenterol. 2006 Jul;101(7):1581-90. (PMID: <searchLink fieldCode="PM" term="%2216863564%22">16863564)</searchLink><br />Int J Food Sci Nutr. 2017 Dec;68(8):987-996. (PMID: <searchLink fieldCode="PM" term="%2228391735%22">28391735)</searchLink><br />Foods. 2020 May 15;9(5):. (PMID: <searchLink fieldCode="PM" term="%2232429251%22">32429251)</searchLink><br />Microorganisms. 2021 Mar 23;9(3):. (PMID: <searchLink fieldCode="PM" term="%2233806783%22">33806783)</searchLink><br />mSystems. 2025 Mar 18;10(3):e0160724. (PMID: <searchLink fieldCode="PM" term="%2239936902%22">39936902)</searchLink><br />Nature. 2019 May;569(7758):655-662. 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(PMID: <searchLink fieldCode="PM" term="%2235889049%22">35889049)</searchLink><br />Aliment Pharmacol Ther. 2005 Sep 1;22(5):387-94. (PMID: <searchLink fieldCode="PM" term="%2216128676%22">16128676)</searchLink><br />Br J Nutr. 2008 Jan;99(1):110-20. (PMID: <searchLink fieldCode="PM" term="%2217761020%22">17761020)</searchLink><br />Crit Rev Food Sci Nutr. 2024;64(22):8036-8053. (PMID: <searchLink fieldCode="PM" term="%2237000015%22">37000015)</searchLink><br />Genome Announc. 2015 Apr 02;3(2):. (PMID: <searchLink fieldCode="PM" term="%2225838473%22">25838473)</searchLink><br />Nutr Res Rev. 2017 Dec;30(2):149-190. (PMID: <searchLink fieldCode="PM" term="%2228676135%22">28676135)</searchLink><br />Front Nutr. 2023 Jul 20;10:1230043. (PMID: <searchLink fieldCode="PM" term="%2237545587%22">37545587)</searchLink><br />BMJ. 2016 Jun 14;353:i2716. (PMID: <searchLink fieldCode="PM" term="%2227301975%22">27301975)</searchLink><br />Gut. 2015 Jan;64(1):93-100. (PMID: <searchLink fieldCode="PM" term="%2225016597%22">25016597)</searchLink><br />Nutr J. 2010 Sep 15;9:37. (PMID: <searchLink fieldCode="PM" term="%2220843361%22">20843361)</searchLink><br />Gastroenterology. 2005 Mar;128(3):541-51. (PMID: <searchLink fieldCode="PM" term="%2215765388%22">15765388)</searchLink><br />Scand J Gastroenterol. 2003 Sep;38(9):947-54. (PMID: <searchLink fieldCode="PM" term="%2214531531%22">14531531)</searchLink><br />ISME J. 2014 Nov;8(11):2218-30. (PMID: <searchLink fieldCode="PM" term="%2224763370%22">24763370)</searchLink><br />J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:53-61. (PMID: <searchLink fieldCode="PM" term="%2228244665%22">28244665)</searchLink><br />Cell Metab. 2017 Jun 6;25(6):1243-1253.e5. (PMID: <searchLink fieldCode="PM" term="%2228591632%22">28591632)</searchLink><br />J Agric Food Chem. 2001 May;49(5):2657-62. (PMID: <searchLink fieldCode="PM" term="%2211368651%22">11368651)</searchLink><br />Gut. 2017 Jul;66(7):1241-1251. (PMID: <searchLink fieldCode="PM" term="%2226976734%22">26976734)</searchLink><br />Compr Rev Food Sci Food Saf. 2020 Nov;19(6):2862-2884. (PMID: <searchLink fieldCode="PM" term="%2233337033%22">33337033)</searchLink> – Name: GrantInfo Label: Grant Information Group: Grant Data: Regionale forskningsfond Oslofjordfondet; Forregion; Mesterbakeren; University of Oslo; OsloMet - Oslo Metropolitan University – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>baker’s yeast bread; dietary fibre; fermentation; gut microbiota; sourdough bread; whole-grain – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260915 <i>Date Completed: </i>20260915 <i>Latest Revision: </i>20260929 – Name: DateUpdate Label: Update Code Group: Date Data: 20260930 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC13567351 – Name: DOI Label: DOI Group: ID Data: 10.3390/nu18172854 – Name: AN Label: PMID Group: ID Data: 42739025 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nu18172854 Languages: – Code: eng Text: English Subjects: – SubjectFull: Feces microbiology Type: general – SubjectFull: Diarrhea microbiology Type: general – SubjectFull: Humans Type: general – SubjectFull: Cross-Over Studies Type: general – SubjectFull: Double-Blind Method Type: general – SubjectFull: Male Type: general – SubjectFull: Adult Type: general – SubjectFull: Female Type: general – SubjectFull: Triticum Type: general – SubjectFull: Middle Aged Type: general – SubjectFull: Bread microbiology Type: general – SubjectFull: Bread analysis Type: general – SubjectFull: Saccharomyces cerevisiae Type: general – SubjectFull: Gastrointestinal Microbiome Type: general Titles: – TitleFull: Sourdough Bread and Baker's Yeast Bread Affect Gut Symptoms and Targeted Gut Microbial Taxa Differently: A Randomised Controlled Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Watters SIN – PersonEntity: Name: NameFull: Henriksen C – PersonEntity: Name: NameFull: Gjøvik M – PersonEntity: Name: NameFull: Garnweidner-Holme L – PersonEntity: Name: NameFull: Frederiksen MP – PersonEntity: Name: NameFull: Jonassen S – PersonEntity: Name: NameFull: Ravnanger I – PersonEntity: Name: NameFull: Myhrstad MCW – PersonEntity: Name: NameFull: Telle-Hansen VH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2026 Sep 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2072-6643 Numbering: – Type: volume Value: 18 – Type: issue Value: 17 Titles: – TitleFull: Nutrients Type: main |
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