Academic Journal
Distinct Mechanisms Mediate Dopamine-Octopamine Opponency in an Insect Model of Olfaction.
| Τίτλος: | Distinct Mechanisms Mediate Dopamine-Octopamine Opponency in an Insect Model of Olfaction. |
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| Συγγραφείς: | Bessonova Y; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130., Clark I; Department of Neuroscience and Behavior, University of Notre Dame, Notre Dame, Indiana 46556., Sumida R; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130., Kelley J; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130., Alva I; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130., Raman B; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130 barani@wustl.edu. |
| Πηγή: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Oct 14; Vol. 46 (41). Date of Electronic Publication: 2026 Oct 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| Ιατρικοί όροι (MeSH): | Grasshoppers*/metabolism , Dopamine*/metabolism , Octopamine*/metabolism , Arthropod Antennae*/metabolism , Smell*, GABAergic Neurons/metabolism ; Receptors, Odorant/metabolism ; Male ; Female ; Animals |
| Περίληψη: | Neuromodulators play a key role in determining how an organism processes and responds to sensory cues. Often, different neuromodulators act on the same set of neural circuits to produce diverging behavioral outcomes. In this study, we examined how dopamine and octopamine alter odor-driven neural activity in a peripheral olfactory circuit (the antennal lobe) of the locusts (Schistocerca americana, both sexes) and thereby alter behavioral responses in an opposing manner. Our results indicate that dopamine suppressed GABAergic local neuron activity during odor stimulation. Releasing the antennal lobe network from inhibition increased the principal neural activity for all odorants and led to nonspecific increases in a behavioral appetitive response. Octopamine, on the other hand, did not alter the GABAergic inhibition in the antennal lobe but still reduced the odor-evoked principal neural activity and the behavioral responses elicited by all odorants. Thus, both dopamine and octopamine used distinct mechanisms (altering recurrent inhibition vs intrinsic excitability) to mediate opponent changes in odor-evoked neural activity and behavioral outcomes. (Copyright © 2026 the authors.) |
| Competing Interests: | The authors declare no competing financial interests. |
| Contributed Indexing: | Keywords: appetitive behavior; neural computation; neural encoding; neuromodulation; olfaction; opponency |
| Substance Nomenclature: | VTD58H1Z2X (Dopamine) 14O50WS8JD (Octopamine) 0 (Receptors, Odorant) |
| Entry Date(s): | Date Created: 20260914 Date Completed: 20261019 Latest Revision: 20261019 |
| Update Code: | 20261020 |
| PubMed Central ID: | PMC13673168 |
| DOI: | 10.1523/JNEUROSCI.2338-25.2026 |
| PMID: | 42736026 |
| Βάση Δεδομένων: | MEDLINE |
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