Academic Journal
Naringin attenuates orchidectomy-induced bone loss in male rats: evidence from bone remodeling and telomere-related indices.
| Τίτλος: | Naringin attenuates orchidectomy-induced bone loss in male rats: evidence from bone remodeling and telomere-related indices. |
|---|---|
| Συγγραφείς: | Zhong Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Wu G; Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, Guangdong, China., Xiong S; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Zhang Y; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Guo Z; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Lu W; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Lan Q; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Zeng Z; Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Chen D; The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Guo H; The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Li Y; The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. leewinly@163.com. |
| Πηγή: | Journal of molecular histology [J Mol Histol] 2026 Sep 10; Vol. 57 (5). Date of Electronic Publication: 2026 Sep 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Netherlands Country of Publication: Netherlands NLM ID: 101193653 Publication Model: Electronic Cited Medium: Internet ISSN: 1567-2387 (Electronic) Linking ISSN: 15672379 NLM ISO Abbreviation: J Mol Histol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dordrecht, The Netherlands : Springer Netherlands Original Publication: Dordrecht, The Netherlands : Kluwer Academic Publishers, 2004- |
| Ιατρικοί όροι (MeSH): | Flavanones*/pharmacology , Flavanones*/therapeutic use , Orchiectomy*/adverse effects , Telomere*/metabolism , Telomere*/drug effects , Bone Remodeling*/drug effects , Osteoporosis*/drug therapy , Osteoporosis*/etiology, Osteoprotegerin/metabolism ; Telomerase/metabolism ; RANK Ligand/metabolism ; Animals ; Male ; Rats, Sprague-Dawley ; Rats |
| Περίληψη: | Androgen deficiency contributes to secondary osteoporosis in men, yet the effects of naringin in androgen-deficient male bone loss remain unclear. We evaluated whether naringin attenuates orchidectomy (ORX)-induced bone loss in male Sprague-Dawley rats and whether this response is accompanied by changes in bone turnover, the OPG/RANKL axis, TERT expression, and relative telomere length. Forty rats were assigned to Sham, ORX, ORX + Naringin, and ORX + Alendronate (ALN) groups. Treatments were administered by oral gavage for 8 weeks. ORX impaired L4 trabecular microarchitecture, shifted serum bone turnover markers toward resorption, reduced the OPG/RANKL ratio, lowered TERT expression, and shortened relative telomere length. Naringin improved BV/TV, Tb.N, Tb.Th, and Tb.Sp; increased OCN and PINP; reduced CTX-I and TRACP-5b; and partially restored the OPG/RANKL balance compared with untreated ORX rats. Naringin was also associated with higher TERT expression and longer relative telomere length, whereas alendronate produced comparable structural and turnover responses but weaker telomere-related changes. These findings suggest that naringin attenuates ORX-induced bone loss in male rats, with coordinated changes in skeletal remodeling and telomere-related indices. (© 2026. The Author(s), under exclusive licence to Springer Nature B.V.) |
| Competing Interests: | Declarations. Ethics approval: The entire experimental protocol was approved by the Laboratory Animal Ethics Committee of Guangzhou University of Chinese Medicine (Approval No. 20230225017) and all procedures were conducted in strict accordance with the Guide for the Care and Use of Laboratory Animals. Competing interests: The authors declare no competing interests. |
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| Grant Information: | GZY-KJS-GD-2025-030 Science and technology co-construction project in the National Demonstration Area of comprehensive Reform of Traditional Chinese Medicine; GZY2025GB0120 Guangzhou University of Traditional Chinese Medicine "Guben" project first-level discipline ability improvement project; 82374482 National Natural Science Foundation of China |
| Contributed Indexing: | Keywords: Male osteoporosis; Naringin; OPG/RANKL; Orchidectomy; TERT; Telomere length |
| Substance Nomenclature: | N7TD9J649B (naringin) 0 (Flavanones) 0 (Osteoprotegerin) EC 2.7.7.49 (Telomerase) 0 (RANK Ligand) |
| Entry Date(s): | Date Created: 20260910 Date Completed: 20260910 Latest Revision: 20261018 |
| Update Code: | 20261018 |
| DOI: | 10.1007/s10735-026-10959-0 |
| PMID: | 42717104 |
| Βάση Δεδομένων: | MEDLINE |
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