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Mesona chinensis Benth polyphenols ameliorate type 2 diabetes mellitus in mice through coordinated regulation of gut microbiota, metabolic profiles, and host metabolic-inflammatory responses.

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Τίτλος: Mesona chinensis Benth polyphenols ameliorate type 2 diabetes mellitus in mice through coordinated regulation of gut microbiota, metabolic profiles, and host metabolic-inflammatory responses.
Συγγραφείς: Chen C; College of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, China., He Q; College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China; Amway (China) R&D Co., Ltd., Guangzhou, Guangdong 510730, China., Cao H; College of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, China., Yu X; College of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, China., Duan J; College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China., Luo R; Amway (China) R&D Co., Ltd., Guangzhou, Guangdong 510730, China., Huang D; Amway (China) R&D Co., Ltd., Guangzhou, Guangdong 510730, China. Electronic address: david.huang@amway.com., Zhou H; College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China; Institute for Safflower Industry Research, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization (Ministry of Education), College of Pharmacy, Shihezi University, Shihezi 832003, China. Electronic address: haibo.zhou@jnu.edu.cn., Zheng J; College of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, China; Institute for Safflower Industry Research, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization (Ministry of Education), College of Pharmacy, Shihezi University, Shihezi 832003, China. Electronic address: junxiazheng@gdut.edu.cn.
Πηγή: Bioorganic chemistry [Bioorg Chem] 2026 Oct 15; Vol. 182, pp. 110467. Date of Electronic Publication: 2026 Sep 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier
Original Publication: New York, London, Academic Press.
Ιατρικοί όροι (MeSH): Polyphenols*/pharmacology , Polyphenols*/chemistry , Polyphenols*/isolation & purification , Polyphenols*/therapeutic use , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/chemically induced , Gastrointestinal Microbiome*/drug effects , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/isolation & purification , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/chemically induced, Inflammation/drug therapy ; Inflammation/metabolism ; Animals ; Mice ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Streptozocin
Περίληψη: Background: Mesona chinensis Benth polyphenols (MCP) have demonstrated potential anti-diabetic activity. However, the underlying mechanisms involved in their metabolic regulation remain incompletely understood.
Objective: This study aimed to investigate the anti-diabetic effects of MCP in HFD/STZ-induced type 2 diabetes mellitus (T2DM) mice through an integrated analysis combining network pharmacology, gut microbiota profiling, metabolomics, and molecular validation.
Materials and Methods: An HFD/STZ-induced T2DM mouse model was established to assess the effects of MCP on glucose metabolism, lipid metabolism, and tissue injury. Network pharmacology was performed to predict potential bioactive compounds, targets, and signaling pathways associated with MCP. Gut microbiota composition and metabolic profiles were analyzed to evaluate MCP-induced alterations in microbial and metabolic homeostasis. Representative proteins involved in glucose metabolism-associated signaling, inflammatory responses, and lipid metabolic regulation were further evaluated by Western blot analysis.
Results: MCP administration significantly improved diabetic phenotypes, as evidenced by reduced fasting blood glucose (FBG), improved oral glucose tolerance test (OGTT) responses, and decreased serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels. Network pharmacology analysis identified multiple candidate pathways potentially involved in the anti-diabetic effects of MCP. Integrated omics analysis revealed that MCP reshaped gut microbiota composition and altered metabolic profiles, particularly pathways related to fatty acid metabolism, including alpha-linolenic acid and linoleic acid metabolism and fatty acid biosynthesis. Molecular validation further demonstrated that MCP modulated representative proteins associated with PI3K-Akt/GLUT4-related glucose metabolism signaling, TNF/MAPK/NF-κB-mediated inflammatory responses, and lipid metabolic regulation.
Conclusion: These findings suggest that MCP exerts anti-diabetic effects through coordinated regulation of gut microbiota remodeling, metabolic alterations, glucose metabolism-associated signaling, inflammatory responses, and lipid metabolic homeostasis. This study provides mechanistic insights into the potential hypoglycemic effects of MCP.
(Copyright © 2026 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Gut microbiota; Mesona chinensis Benth polyphenols; Metabolomics; Network pharmacology; Type 2 diabetes mellitus
Substance Nomenclature: 0 (Polyphenols)
0 (Hypoglycemic Agents)
5W494URQ81 (Streptozocin)
Entry Date(s): Date Created: 20260909 Date Completed: 20261008 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1016/j.bioorg.2026.110467
PMID: 42715624
Βάση Δεδομένων: MEDLINE
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  Data: Mesona chinensis Benth polyphenols ameliorate type 2 diabetes mellitus in mice through coordinated regulation of gut microbiota, metabolic profiles, and host metabolic-inflammatory responses.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 Oct 15; Vol. 182, pp. 110467. <i>Date of Electronic Publication: </i>2026 Sep 06.
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  Label: Abstract
  Group: Ab
  Data: Background: Mesona chinensis Benth polyphenols (MCP) have demonstrated potential anti-diabetic activity. However, the underlying mechanisms involved in their metabolic regulation remain incompletely understood.<br />Objective: This study aimed to investigate the anti-diabetic effects of MCP in HFD/STZ-induced type 2 diabetes mellitus (T2DM) mice through an integrated analysis combining network pharmacology, gut microbiota profiling, metabolomics, and molecular validation.<br />Materials and Methods: An HFD/STZ-induced T2DM mouse model was established to assess the effects of MCP on glucose metabolism, lipid metabolism, and tissue injury. Network pharmacology was performed to predict potential bioactive compounds, targets, and signaling pathways associated with MCP. Gut microbiota composition and metabolic profiles were analyzed to evaluate MCP-induced alterations in microbial and metabolic homeostasis. Representative proteins involved in glucose metabolism-associated signaling, inflammatory responses, and lipid metabolic regulation were further evaluated by Western blot analysis.<br />Results: MCP administration significantly improved diabetic phenotypes, as evidenced by reduced fasting blood glucose (FBG), improved oral glucose tolerance test (OGTT) responses, and decreased serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels. Network pharmacology analysis identified multiple candidate pathways potentially involved in the anti-diabetic effects of MCP. Integrated omics analysis revealed that MCP reshaped gut microbiota composition and altered metabolic profiles, particularly pathways related to fatty acid metabolism, including alpha-linolenic acid and linoleic acid metabolism and fatty acid biosynthesis. Molecular validation further demonstrated that MCP modulated representative proteins associated with PI3K-Akt/GLUT4-related glucose metabolism signaling, TNF/MAPK/NF-κB-mediated inflammatory responses, and lipid metabolic regulation.<br />Conclusion: These findings suggest that MCP exerts anti-diabetic effects through coordinated regulation of gut microbiota remodeling, metabolic alterations, glucose metabolism-associated signaling, inflammatory responses, and lipid metabolic homeostasis. This study provides mechanistic insights into the potential hypoglycemic effects of MCP.<br /> (Copyright © 2026 Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Gut microbiota; Mesona chinensis Benth polyphenols; Metabolomics; Network pharmacology; Type 2 diabetes mellitus
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