Academic Journal
Association of betel quid chewing with specific major psychiatric disorders in Taiwan Biobank-NHIRD linked data.
| Τίτλος: | Association of betel quid chewing with specific major psychiatric disorders in Taiwan Biobank-NHIRD linked data. |
|---|---|
| Συγγραφείς: | Liu MN; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen KC; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan., Chen MH; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Kuo PH; Department of Public Health & Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Tsai SJ; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. |
| Πηγή: | Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2026 Sep 09; Vol. 35, pp. e54. Date of Electronic Publication: 2026 Sep 09. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 101561091 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-7979 (Electronic) Linking ISSN: 20457960 NLM ISO Abbreviation: Epidemiol Psychiatr Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Cambridge University Press |
| Ιατρικοί όροι (MeSH): | Areca*/adverse effects , Mental Disorders*/epidemiology , Mental Disorders*/psychology, Taiwan/epidemiology ; Major Depressive Disorder/epidemiology ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Bipolar Disorder/epidemiology ; Schizophrenia/epidemiology ; Obsessive-Compulsive Disorder/epidemiology ; Humans ; Male ; Middle Aged ; Adult ; Aged ; Prevalence ; Mastication ; Generalized Anxiety Disorder |
| Περίληψη: | Aims: Betel quid chewing (BQC) is a common psychoactive habit in Taiwan and other Asian regions. Evidence regarding its association with specific psychiatric disorders remains limited. This study examined associations between BQC assessed at Taiwan Biobank enrolment and major psychiatric disorders recorded in linked health-insurance claims data. Methods: We analysed 51,522 male participants from the Taiwan Biobank successfully linked to the National Health Insurance Research Database, including 7,973 ever-users (BQC) and 43,549 never-users of betel quid (non-BQC). Psychiatric disorders included schizophrenia, bipolar disorder, major depressive disorder (MDD), depressive disorders, obsessive-compulsive disorder (OCD), panic disorder, generalized anxiety disorder, attention-deficit/hyperactivity disorder (ADHD) and dementia. Multivariable logistic regression models were constructed with sequential adjustment for age, claims-record ascertainment period, education, urbanization, cigarette smoking and alcohol drinking. No correction for multiple testing was applied across the nine psychiatric outcomes. Results: Compared with non-users, BQC users were older, had lower educational attainment and had markedly higher prevalence of cigarette smoking and alcohol drinking. In crude analyses, BQC was associated with higher odds of schizophrenia, bipolar disorder, MDD, depressive disorders, and panic disorder but lower odds of OCD and ADHD. After full adjustment, BQC remained associated with depressive disorders (adjusted OR: 1.19, 95% CI: 1.09-1.31). An exploratory inverse estimate for OCD (adjusted OR: 0.62, 95% CI: 0.39-0.98) was based on only 24 exposed cases. All estimates were nominal because no correction for multiple testing was applied. Conclusions: In these linked Taiwanese data, BQC was modestly associated with depressive disorders, whereas associations with most other psychiatric conditions were attenuated after adjustment for sociodemographic and lifestyle factors. As BQC was assessed at a single time point and psychiatric diagnoses could predate or follow that assessment, the findings represent associations and do not establish temporality or causality. |
| Grant Information: | NSTC 112-2314-B-075-013-MY3 NSTC 114-2321-B-A49-003 NSTC 113-2314-B-002-168-MY3 V114C-007 V114D81-004-MY2-1 National Science and Technology Council |
| Contributed Indexing: | Keywords: National Health Insurance Research Database; Taiwan Biobank; betel quid chewing; depression; health-insurance claims; psychiatric disorders |
| Entry Date(s): | Date Created: 20260909 Date Completed: 20260909 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1017/S2045796026100936 |
| PMID: | 42713675 |
| Βάση Δεδομένων: | MEDLINE |
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