Academic Journal
Tranexamic Acid Administration in Laparoscopic Sleeve Gastrectomy.
| Τίτλος: | Tranexamic Acid Administration in Laparoscopic Sleeve Gastrectomy. |
|---|---|
| Συγγραφείς: | Eldegwy MH; Al Azhar University, Cairo, Egypt. magdydegwy@gmail.com.; Hamad Medical Corporation, Doha, Qatar. magdydegwy@gmail.com., Ragab HO; Al Azhar University, Cairo, Egypt., Alafifi MAT; Al Azhar University, Cairo, Egypt., Elzoughari IA; Al Azhar University, Cairo, Egypt., Salem HA; Al Azhar University, Cairo, Egypt., Shokr WH; Cairo University, Giza, Egypt., Almukhlifi TS; Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia., Elkenany HMN; Al Azhar University, Cairo, Egypt., Hegab M; Al Azhar University, Cairo, Egypt., Mahmoud MA; Al-Azhar University, Assiut, Egypt., Ebrahim AAA; Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Awad EA; Al Azhar University, Cairo, Egypt., Hassan AE; Al Azhar University, Cairo, Egypt., Shaffik AM; Benha University, Banhā, Egypt. |
| Πηγή: | Obesity surgery [Obes Surg] 2026 Oct; Vol. 36 (10), pp. 5131-5144. Date of Electronic Publication: 2026 Sep 08. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2006- : New York : Springer Science + Business Media Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991- |
| Ιατρικοί όροι (MeSH): | Tranexamic Acid*/therapeutic use , Tranexamic Acid*/administration & dosage , Gastrectomy*/methods , Gastrectomy*/adverse effects , Obesity, Morbid*/surgery , Antifibrinolytic Agents*/therapeutic use , Antifibrinolytic Agents*/administration & dosage , Blood Loss, Surgical*/prevention & control , Postoperative Hemorrhage*/prevention & control , Laparoscopy*, Length of Stay/statistics & numerical data ; Humans ; Female ; Operative Time |
| Περίληψη: | Background and Aim: Perioperative bleeding remains one of the most frequent early complications of laparoscopic sleeve gastrectomy (LSG). The present work aimed to provide a thorough and updated systematic review and meta-analysis of the published studies on the use of tranexamic acid (TXA) in LSG. Methods: The present study was conducted according to the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) guidelines. A systematic literature search was conducted in PubMed, Scopus, and Web of Science. Results: The present study analyzed 9 studies. They included 1665 patients. TXA was administered to 842 patients while 823 patients received no intervention or placebo. Pooled analysis revealed significantly shorter operative duration [mean difference (95% CI): -4.56 (-7.36, -1.76), p = 0.001], shorter length of hospital stay [mean difference (95% CI): -0.12 (-0.16, -0.08), p<0.00001] and lower reduction of preoperative hemoglobin levels in the TXA arm [mean difference (95% CI): -0.2 (-0.38, -0.02), p = 0.03]. No significant differences were found between the interventional arms regarding number of used intraoperative hemostatic clips [mean difference (95% CI): -0.2 (-0.93, 0.53), p = 0.59], number of patients requiring blood transfusion [RD (95% CI): -0.01 (-0.02, 0.0), p = 0.08] or number of patients requiring reoperation for bleeding [RD (95% CI): -0.01 (-0.03, 0.0), p = 0.12]. No thromboembolic events were reported. Conclusions: The present study suggests that, based on the currently available evidence, intraoperative administration of TXA is associated with lower reduction of preoperative hemoglobin levels in patients undergoing LSG, which may contribute to shorter operative duration and reduced length of hospital stay. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Bariatric surgery; Laparoscopic sleeve gastrectomy; Stable line bleeding; Tranexamic acid |
| Substance Nomenclature: | 6T84R30KC1 (Tranexamic Acid) 0 (Antifibrinolytic Agents) |
| Entry Date(s): | Date Created: 20260909 Date Completed: 20261007 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s11695-026-08909-6 |
| PMID: | 42711637 |
| Βάση Δεδομένων: | MEDLINE |
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