Academic Journal
Learning-enhanced hybrid planar-SPECT dosimetry for voxel-level Monte Carlo dose estimation in radionuclide therapy.
| Τίτλος: | Learning-enhanced hybrid planar-SPECT dosimetry for voxel-level Monte Carlo dose estimation in radionuclide therapy. |
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| Συγγραφείς: | Dong Z; National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, People's Republic of China., Jin X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, People's Republic of China., Meng X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, People's Republic of China., Liu W; National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, People's Republic of China., Li N; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, People's Republic of China., Yang Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, People's Republic of China., Ren Q; National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, People's Republic of China., Yu J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, People's Republic of China., Xie Z; National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, People's Republic of China.; Institute of Medical Technology, Peking University Health Science Center, Peking University, Beijing 100191, People's Republic of China. |
| Πηγή: | Physics in medicine and biology [Phys Med Biol] 2026 Sep 28; Vol. 71 (19). Date of Electronic Publication: 2026 Sep 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol : IOP Publishing |
| Ιατρικοί όροι (MeSH): | Monte Carlo Method* , Tomography, Emission-Computed, Single-Photon* , Radiation Dosage* , Single Photon Emission Computed Tomography Computed Tomography*, Radiometry/methods ; Octreotide/analogs & derivatives ; Octreotide/therapeutic use ; Humans ; Radiotherapy Dosage |
| Περίληψη: | Objective.Quantitative imaging-based dosimetry is essential for optimizing [177Lu]Lu-DOTATATE peptide receptor radionuclide therapy, yet full multi-time-point (MTP) SPECT/CT is difficult to implement in routine clinical practice. This study proposes a hybrid planar-SPECT framework for organ-level time-integrated activity (TIA) estimation and single-time-point (STP)-constrained voxel-level Monte Carlo (MC) dose analysis from a single post-therapy SPECT/CT acquisition.Approach.The proposed framework integrates STP SPECT/CT with serial planar imaging to derive organ-level TIAs. A physics-informed support vector regression (SVR) model is incorporated to refine planar-to-SPECT scaling factors and improve the robustness of planar-derived activity quantification. The resulting organ TIAs are used to scale the fixed within-organ STP SPECT pattern and generate voxelized TIA maps as source distributions for MC-based dose calculation. The method is evaluated against reference MTP SPECT/CT data in 11 patients and further applied to a separate cohort of 23 patients to explore vertebral dose heterogeneity and its association with hematologic toxicity.Main results.Hybrid dosimetry showed good agreement with MTP SPECT/CT, with organ-level errors of approximately 10%-15%. The SVR-based refinement modestly reduced scaling bias, particularly in anatomically challenging structures. Voxel-level vertebral dose heterogeneity metrics showed moderate but exploratory correlations with hematologic toxicity (ρ≈ 0.4-0.5) after false-discovery-rate correction, whereas conventional organ-averaged dose metrics showed no significant association.Significance.The proposed hybrid planar-SPECT framework supports clinically feasible organ-level dosimetry from a reduced acquisition protocol. The resulting voxelized maps provide STP-constrained approximate source distributions for MC dose calculation and exploratory characterization of spatial dose heterogeneity, rather than reconstructions of time-varying MTP voxel kinetics. The SVR improvement observed in the 11-patient internal validation remains preliminary, requiring larger cohorts for robustness and external validation for generalizability. (© 2026 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.) |
| Contributed Indexing: | Keywords: SPECT; [177Lu]Lu-DOTATATE; hybrid dosimetry; peptide receptor radionuclide therapy; voxel-level dosimetry |
| Substance Nomenclature: | RWM8CCW8GP (Octreotide) |
| Entry Date(s): | Date Created: 20260907 Date Completed: 20260928 Latest Revision: 20260928 |
| Update Code: | 20260928 |
| DOI: | 10.1088/1361-6560/aea39b |
| PMID: | 42705340 |
| Βάση Δεδομένων: | MEDLINE |
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