Academic Journal
Evidence for nephrolithiasis preceding sarcoidosis diagnosis: findings from a Swedish case-control study.
| Τίτλος: | Evidence for nephrolithiasis preceding sarcoidosis diagnosis: findings from a Swedish case-control study. |
|---|---|
| Συγγραφείς: | Werner J; Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Gävlegatan 55, Stockholm, NB3:03, SE-171 76, Sweden. joanna.werner@ki.se.; Department of Respiratory Medicine, Theme Inflammation and Ageing, Karolinska University Hospital, Stockholm, Sweden. joanna.werner@ki.se., Arkema EV; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Thiel T; Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.; Department of Urology, Karolinska University Hospital, Stockholm, Sweden., Batyrbekova N; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Kullberg S; Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Gävlegatan 55, Stockholm, NB3:03, SE-171 76, Sweden.; Department of Respiratory Medicine, Theme Inflammation and Ageing, Karolinska University Hospital, Stockholm, Sweden. |
| Πηγή: | Respiratory research [Respir Res] 2026 Aug 28; Vol. 27 (1). Date of Electronic Publication: 2026 Aug 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : London : BioMed Central Ltd. Original Publication: London : Current Science Ltd., c2000- |
| Ιατρικοί όροι (MeSH): | Nephrolithiasis*/epidemiology , Nephrolithiasis*/diagnosis , Sarcoidosis*/epidemiology , Sarcoidosis*/diagnosis, Sweden/epidemiology ; Humans ; Female ; Case-Control Studies ; Male ; Middle Aged ; Risk Factors ; Adult ; Registries ; Aged |
| Περίληψη: | Background: Patients with sarcoidosis have an increased risk for calcium metabolism disturbances, such as hypercalcemia and hypercalciuria. Previous studies suggest that nephrolithiasis (stone formation in the renal and ureter, often caused by dysregulated calcium balance) may occur long before sarcoidosis diagnosis and may be an early sign of not-yet-diagnosed sarcoidosis. We hypothesized that a history of nephrolithiasis is associated with future risk of sarcoidosis. Methods: In this population-based matched case-control study, we included individuals with sarcoidosis and matched general population controls and identified those with a history of nephrolithiasis in Swedish nationwide registers. Patients with sarcoidosis who received treatment within three months of their sarcoidosis diagnosis were classified as severe. Nephrolithiasis severity was defined based on the need for intervention, multiple stones and early onset. Conditional logistic regression models estimated adjusted odds ratios with 95% confidence intervals (OR; 95%CI). Results: A total of 10,904 sarcoidosis patients and 99,211 general population controls were included. At sarcoidosis diagnosis, 4.5% of patients had a history of nephrolithiasis compared to 2.6% of controls. Nephrolithiasis was associated with a 61% increased odds of sarcoidosis (adjusted OR = 1.61; 95%CI 1.46-1.78). The OR of severe sarcoidosis associated with a history of severe nephrolithiasis was 1.35 (95%CI 0.58-3.16). Conclusions: These findings indicate that nephrolithiasis might be an early sign of sarcoidosis in a subset of patients. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Regional Ethical Review Board in Stockholm (DNR: 2014/230-31, 2021-01856). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Calcium metabolism; Nephrolithiasis; Sarcoidosis |
| Entry Date(s): | Date Created: 20260907 Date Completed: 20260907 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| PubMed Central ID: | PMC13548631 |
| DOI: | 10.1186/s12931-026-03877-y |
| PMID: | 42702710 |
| Βάση Δεδομένων: | MEDLINE |
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