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Resting-state functional connectivity in default mode and frontoparietal networks predicts directed forgetting.

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Τίτλος: Resting-state functional connectivity in default mode and frontoparietal networks predicts directed forgetting.
Συγγραφείς: Gai R; School of Psychology, Liaoning Normal University, Dalian, 116029, China., Jing J; School of Psychology, Liaoning Normal University, Dalian, 116029, China., Qi M; School of Psychology, Liaoning Normal University, Dalian, 116029, China. Electronic address: qimingzhixin@126.com., Gao H; School of Psychology, Liaoning Normal University, Dalian, 116029, China. Electronic address: gaoheming@lnnu.edu.cn.
Πηγή: NeuroImage [Neuroimage] 2026 Oct 15; Vol. 340, pp. 122201. Date of Electronic Publication: 2026 Sep 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
Imprint Name(s): Original Publication: Orlando, FL : Academic Press, c1992-
Ιατρικοί όροι (MeSH): Parietal Lobe*/physiology , Parietal Lobe*/diagnostic imaging , Default Mode Network*/physiology , Default Mode Network*/diagnostic imaging , Nerve Net*/physiology , Nerve Net*/diagnostic imaging , Frontal Lobe*/physiology , Frontal Lobe*/diagnostic imaging , Mental Recall*/physiology , Connectome*/methods, Humans ; Female ; Young Adult ; Magnetic Resonance Imaging ; Adolescent ; Adult ; Male ; Brain Mapping ; Cues
Περίληψη: Directed forgetting (DF) refers to the goal-directed modulation of memory, typically manifested as superior memory for information cued to be remembered (TBR) compared to information cued to be forgotten (TBF). Although prior studies have emphasized task-evoked neural mechanisms of DF, it remains unclear whether intrinsic brain network organization contributes to individual differences in memory control. The present study examined whether resting-state functional connectivity within and between the default mode network (DMN) and frontoparietal network (FPN) predicts individual differences in DF performance. Forty-seven healthy college students (31 females; aged 18-28 years) underwent resting-state fMRI scanning and completed an item-method DF task. Behavioral results showed significantly better recognition for TBR than TBF items, confirming a DF effect. Connectivity analyses revealed that, 1) stronger within-DMN connectivity centered on the right precuneus/posterior cingulate cortex (pCun/PCC) was associated with better memory for TBR items and a larger DF effect. 2) Stronger within-FPN connectivity, especially between the right dorsolateral prefrontal cortex and bilateral inferior parietal lobule, predicted poorer memory for TBF items. 3) Moreover, stronger anticorrelation between the FPN and mnemonic regions was associated with better memory for TBR items, poorer memory for TBF items, and a larger DF effect. These findings suggest that DF depends on dissociable but coordinated intrinsic network properties supporting selective remembering, active forgetting, and functional segregation between mnemonic and control systems.
(Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare no competing interests.
Contributed Indexing: Keywords: Default mode network; Directed forgetting; Frontoparietal network; Resting-state functional connectivity
Entry Date(s): Date Created: 20260905 Date Completed: 20260929 Latest Revision: 20260929
Update Code: 20260930
DOI: 10.1016/j.neuroimage.2026.122201
PMID: 42700851
Βάση Δεδομένων: MEDLINE
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  Data: Resting-state functional connectivity in default mode and frontoparietal networks predicts directed forgetting.
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  Data: Directed forgetting (DF) refers to the goal-directed modulation of memory, typically manifested as superior memory for information cued to be remembered (TBR) compared to information cued to be forgotten (TBF). Although prior studies have emphasized task-evoked neural mechanisms of DF, it remains unclear whether intrinsic brain network organization contributes to individual differences in memory control. The present study examined whether resting-state functional connectivity within and between the default mode network (DMN) and frontoparietal network (FPN) predicts individual differences in DF performance. Forty-seven healthy college students (31 females; aged 18-28 years) underwent resting-state fMRI scanning and completed an item-method DF task. Behavioral results showed significantly better recognition for TBR than TBF items, confirming a DF effect. Connectivity analyses revealed that, 1) stronger within-DMN connectivity centered on the right precuneus/posterior cingulate cortex (pCun/PCC) was associated with better memory for TBR items and a larger DF effect. 2) Stronger within-FPN connectivity, especially between the right dorsolateral prefrontal cortex and bilateral inferior parietal lobule, predicted poorer memory for TBF items. 3) Moreover, stronger anticorrelation between the FPN and mnemonic regions was associated with better memory for TBR items, poorer memory for TBF items, and a larger DF effect. These findings suggest that DF depends on dissociable but coordinated intrinsic network properties supporting selective remembering, active forgetting, and functional segregation between mnemonic and control systems.<br /> (Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.)
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  Data: Declaration of competing interest The authors declare no competing interests.
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      – TitleFull: Resting-state functional connectivity in default mode and frontoparietal networks predicts directed forgetting.
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