A novel preclinical system for cascade gamma photon coincidence imaging with high resolution and sensitivity.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	A novel preclinical system for cascade gamma photon coincidence imaging with high resolution and sensitivity.
Συγγραφείς:	Xu S; Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, People's Republic of China., Wang K; Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, People's Republic of China., Wei Q; Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, People's Republic of China., Liu H; Department of Engineering Physics, Tsinghua University, Beijing, People's Republic of China., Wu J; Center for Advanced Quantum Studies, School of Physics and Astronomy, Beijing Normal University, Beijing, People's Republic of China., Liu Y; Department of Engineering Physics, Tsinghua University, Beijing, People's Republic of China., He ZX; Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Πηγή:	Physics in medicine and biology [Phys Med Biol] 2026 Sep 16; Vol. 71 (17). Date of Electronic Publication: 2026 Sep 16.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE
Imprint Name(s):	Original Publication: Bristol : IOP Publishing
Ιατρικοί όροι (MeSH):	Photons* , Gamma Rays* , Signal-To-Noise Ratio*, Monte Carlo Method ; Phantoms, Imaging ; Image Processing, Computer-Assisted
Περίληψη:	Objective. Cascade gamma-emitting radionuclides such as¹⁷⁷Lu offer unique opportunities for theranostic applications, yet existing imaging systems face inherent trade-offs between spatial resolution and detection sensitivity. To address this limitation, we present a novel time-space coincidence imaging system specifically designed for cascade gamma photons, aiming to achieve both high spatial resolution and high sensitivity in a single platform.Approach. The proposed system employs a full-ring LaBr3detector array combined with hybrid pinhole-slit collimators, which synergistically integrate the high spatial resolution of pinhole collimation with the high detection efficiency of slit collimation. The imaging performance was evaluated through Monte Carlo simulations using both a point source and a Derenzo phantom, with¹⁷⁷Lu as the radionuclide source, which emits cascade gamma-ray pairs at 113 keV and 208 keV. Image reconstruction was performed using direct back-projection (DBP) and maximum likelihood expectation maximization (MLEM), alongside two newly developed algorithms: refined DBP (R-DBP) and multi-information joint reconstruction (MIJR).Main results. The system achieved a central coincidence sensitivity of 2.97 × 10^-5and an average spatial resolution of 2.32 mm. In Derenzo phantom imaging, hot rods with diameters as small as 1.2 mm were clearly resolved, and the contrast-to-noise ratio (CNR) for the largest rods reached 9.29. The use of the R-DBP algorithm effectively reduced image artifacts. Compared with the DBP algorithm, the CNR of the reconstructed images was improved by an average of 4.37%. Under low-count conditions, the MIJR algorithm achieved an average CNR improvement of 3.80% over the MLEM algorithm. These quantitative results demonstrate that the hybrid collimator design effectively balances resolution and sensitivity, outperforming conventional cascade gamma imaging approaches.Significance. These results demonstrate that the proposed hybrid collimator design provides a favorable balance between spatial resolution and coincidence sensitivity, achieving better spatial resolution than previously reported systems while maintaining higher sensitivity than conventional collimated approaches. By combining high-resolution imaging, practical sensitivity, and inherent theranostic capability with¹⁷⁷Lu, this technology provides a promising platform for integrated diagnosis and therapy in preclinical and potentially clinical applications. (© 2026 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)
Contributed Indexing:	Keywords: Monte Carlo simulation; cascade gamma photon; coincidence imaging; pinhole-slit collimation; ring LaBr3 detector
Entry Date(s):	Date Created: 20260904 Date Completed: 20260916 Latest Revision: 20260916
Update Code:	20260916
DOI:	10.1088/1361-6560/aea305
PMID:	42697241
Βάση Δεδομένων:	MEDLINE

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