Academic Journal
An Oxycodone-Based Conscious Analgesia Strategy with Supplemental Low-Dose Propofol Improves Safety in Elderly Obese Patients Undergoing Gastroscopy: A Prospective Randomized Controlled Trial.
| Τίτλος: | An Oxycodone-Based Conscious Analgesia Strategy with Supplemental Low-Dose Propofol Improves Safety in Elderly Obese Patients Undergoing Gastroscopy: A Prospective Randomized Controlled Trial. |
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| Συγγραφείς: | Chang H; Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Hunan, Changsha, 410013, People's Republic of China., Zhu X; Department of Anesthesiology, Xiangya Hospital, Central South University, Hunan, Changsha, 410008, People's Republic of China., Chen J; Department of Endocrinology, The First Hospital of Changsha, Changsha, Hunan, 410005, People's Republic of China., Chin M; Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Hunan, Changsha, 410013, People's Republic of China., Zhan C; Department of Anesthesiology, Xiangya School of Medicine, Central South University, Hunan, Changsha, 410013, People's Republic of China., Zhang F; Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Hunan, Changsha, 410013, People's Republic of China. |
| Πηγή: | Drug design, development and therapy [Drug Des Devel Ther] 2026 Aug 30; Vol. 20, pp. 625073. Date of Electronic Publication: 2026 Aug 30 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Auckland, N.Z.] : Dove Press Limited |
| Ιατρικοί όροι (MeSH): | Analgesics, Opioid*/administration & dosage , Obesity*/drug therapy , Oxycodone*/administration & dosage , Oxycodone*/adverse effects , Propofol*/administration & dosage , Propofol*/adverse effects , Gastroscopy*, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Analgesia ; Dose-Response Relationship, Drug ; Geriatric Anesthesia ; Prospective Studies |
| Περίληψη: | Background: During diagnostic gastroscopy, intolerance is usually manifested as retching, coughing, and involuntary movement. Conscious analgesia relieves discomfort while patients continue to breathe spontaneously and remain partly responsive. Oxycodone, a semi-synthetic opioid, may reduce the need for deep propofol sedation. We compared an oxycodone-based conscious analgesia strategy with supplemental low-dose propofol with propofol-based deep sedation in elderly obese patients. Patients and Methods: In this prospective, single-center, open-label randomized controlled trial, 128 patients aged ≥65 years with a body mass index of 30-39.9 kg/m2 undergoing elective gastroscopy were randomized 1:1 to propofol-based deep sedation (group P) or oxycodone-based conscious analgesia with supplemental low-dose propofol (group OP). The primary outcome was the incidence of hypoxemia, defined as any SpO Results: All 128 randomized patients completed the study. Hypoxemia occurred less frequently in group OP than in group P (10.94% vs 37.50%; relative risk, 0.29; 95% CI, 0.14-0.63; P<0.001). Group OP also required fewer airway interventions (10.94% vs 37.50%; P<0.001), and mask-assisted ventilation was required less often (1.56% vs 32.81%; P<0.001). Hypotension was less frequent (9.38% vs 28.13%; P=0.012), total propofol consumption was lower (0.38±0.13 vs 1.70±0.25 mg/kg; P<0.001), and time to full wakefulness was shorter (3.89±0.73 vs 8.21±1.12 minutes; P<0.001) in group OP. Conclusion: Compared with propofol-based deep sedation, the oxycodone-based conscious analgesia strategy was associated with a lower incidence of hypoxemia, fewer airway interventions, less hypotension, lower propofol exposure, and faster recovery. These findings reflect a comparison of two sedation strategies and do not establish improved respiratory function. (© 2026 Chang et al.) |
| Competing Interests: | The authors report no conflicts of interest in this work. |
| References: | J Clin Anesth. 2021 Aug;71:110245. (PMID: 33740700) Gastrointest Endosc. 2021 Jan;93(1):201-208. (PMID: 32504701) BMC Anesthesiol. 2022 Mar 28;22(1):85. (PMID: 35346041) BMC Anesthesiol. 2025 Oct 7;25(1):484. (PMID: 41057755) Br J Anaesth. 2024 Jun;132(6):1219-1229. (PMID: 38443286) Gastrointest Endosc. 2026 Mar;103(3):438-450. (PMID: 40962231) BMC Anesthesiol. 2025 Aug 25;25(1):417. (PMID: 40855262) Gerontology. 2024;70(5):455-460. (PMID: 38316110) BMC Anesthesiol. 2025 Jul 30;25(1):366. (PMID: 40739469) World J Gastrointest Pharmacol Ther. 2025 Jun 5;16(2):102098. (PMID: 40575362) World J Gastrointest Endosc. 2025 Jun 16;17(6):106604. (PMID: 40547560) Dig Liver Dis. 2025 Jun;57(6):1266-1272. (PMID: 39710566) Can J Anaesth. 2020 Sep;67(9):1182-1189. (PMID: 32514693) J Clin Med. 2024 Aug 08;13(16):. (PMID: 39200777) Medicine (Baltimore). 2022 Dec 23;101(51):e32427. (PMID: 36595823) BMC Anesthesiol. 2026 Jan 14;26(1):105. (PMID: 41535780) Gut. 2024 Jan 5;73(2):219-245. (PMID: 37816587) Eur J Med Res. 2025 May 2;30(1):355. (PMID: 40312693) Gastrointest Endosc. 2018 Feb;87(2):327-337. (PMID: 29306520) Minerva Anestesiol. 2024 Sep;90(9):775-784. (PMID: 38775443) Clin Pharmacokinet. 2018 Dec;57(12):1539-1558. (PMID: 30019172) BMC Anesthesiol. 2025 Nov 6;25(1):548. (PMID: 41199161) J Clin Anesth. 2023 May;85:111042. (PMID: 36549036) Medicine (Baltimore). 2017 Mar;96(10):e6286. (PMID: 28272250) J Can Assoc Gastroenterol. 2020 Jun;3(3):141-144. (PMID: 32395689) |
| Contributed Indexing: | Keywords: conscious analgesia; elderly obese patients; gastroscopy; oxycodone; propofol |
| Substance Nomenclature: | 0 (Analgesics, Opioid) CD35PMG570 (Oxycodone) YI7VU623SF (Propofol) |
| Entry Date(s): | Date Created: 20260904 Date Completed: 20260904 Latest Revision: 20260911 |
| Update Code: | 20260911 |
| PubMed Central ID: | PMC13541069 |
| DOI: | 10.2147/DDDT.S625073 |
| PMID: | 42694812 |
| Βάση Δεδομένων: | MEDLINE |
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