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The effects of desensitizing agents on dentin permeability using a hydraulic conductance device.

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Τίτλος: The effects of desensitizing agents on dentin permeability using a hydraulic conductance device.
Συγγραφείς: Saraç B; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University., Alkan E; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University., Bittar A; Department of Restorative Dentistry, Faculty of Dentistry, Istinye University., Oğrak I; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University., Korkut B; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University., Çelebi K; SPC Cosmetics., Tağtekin D; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.
Πηγή: Dental materials journal [Dent Mater J] 2026 Sep 25; Vol. 45 (5), pp. 659-667. Date of Electronic Publication: 2026 Sep 02.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Japanese Society for Dental Materials and Devices Country of Publication: Japan NLM ID: 8309299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1361 (Electronic) Linking ISSN: 02874547 NLM ISO Abbreviation: Dent Mater J Subsets: MEDLINE
Imprint Name(s): Original Publication: Tokyo-to : Japanese Society for Dental Materials and Devices, [1982?-
Ιατρικοί όροι (MeSH): Dentin Desensitizing Agents*/pharmacology , Dentin Permeability*/drug effects, Dentin/drug effects ; Sodium Fluoride/pharmacology ; Glass Ionomer Cements/pharmacology ; Glass Ionomer Cements/chemistry ; Calcium Phosphates/pharmacology ; Calcium Phosphates/chemistry ; Humans ; Microscopy, Electron, Scanning ; In Vitro Techniques ; Dentin Sensitivity
Περίληψη: This in vitro study evaluated the effects of a sodium-fluoride varnish, two surface pre-reacted glass-ionomer (S-PRG)-containing agents, and an experimental glycerol-stabilized calcium phosphate cluster (GCPC) gel on dentin permeability using a custom hydraulic conductance apparatus. Horizontal 1-mm coronal dentin disks were prepared from extracted human molars, conditioned with 2% citric acid, and randomized to ClinPro Fluoride Treatment, PRG Barrier-Coat, PRG Pro-Care Gel, experimental GCPC gel, or distilled-water control (n=10/group). Hydraulic conductance was calculated at 3 psi from the time required for 50 µL of water to pass through each specimen. ClinPro and PRG Barrier-Coat significantly reduced permeability after the first post-treatment evaluation, whereas ClinPro and both PRG agents produced near-zero values after the second evaluation. GCPC yielded a moderate but significant reduction. Scanning electron microscopy findings were consistent with progressive dentinal tubule occlusion.
Contributed Indexing: Keywords: Dentin hypersensitivity; Dentin permeability; Dentinal fluid flow; Desensitizing agents; Hydraulic conductance
Substance Nomenclature: 0 (Dentin Desensitizing Agents)
8ZYQ1474W7 (Sodium Fluoride)
0 (Glass Ionomer Cements)
0 (Calcium Phosphates)
Entry Date(s): Date Created: 20260902 Date Completed: 20260927 Latest Revision: 20260927
Update Code: 20260928
DOI: 10.4012/dmj.2026-016
PMID: 42686539
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42686539
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Data: The effects of desensitizing agents on dentin permeability using a hydraulic conductance device.
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  Data: <searchLink fieldCode="AU" term="%22Saraç+B%22">Saraç B</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.<br /><searchLink fieldCode="AU" term="%22Alkan+E%22">Alkan E</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.<br /><searchLink fieldCode="AU" term="%22Bittar+A%22">Bittar A</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Istinye University.<br /><searchLink fieldCode="AU" term="%22Oğrak+I%22">Oğrak I</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.<br /><searchLink fieldCode="AU" term="%22Korkut+B%22">Korkut B</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.<br /><searchLink fieldCode="AU" term="%22Çelebi+K%22">Çelebi K</searchLink>; SPC Cosmetics.<br /><searchLink fieldCode="AU" term="%22Tağtekin+D%22">Tağtekin D</searchLink>; Department of Restorative Dentistry, Faculty of Dentistry, Marmara University.
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  Data: <searchLink fieldCode="JN" term="%228309299%22">Dental materials journal</searchLink> [Dent Mater J] 2026 Sep 25; Vol. 45 (5), pp. 659-667. <i>Date of Electronic Publication: </i>2026 Sep 02.
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Japanese+Society+for+Dental+Materials+and+Devices%22">Japanese Society for Dental Materials and Devices </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>8309299 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1881-1361 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202874547%22">02874547 </searchLink><i>NLM ISO Abbreviation: </i>Dent Mater J <i>Subsets: </i>MEDLINE
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  Label: Imprint Name(s)
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  Data: <i>Original Publication</i>: Tokyo-to : Japanese Society for Dental Materials and Devices, [1982?-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents%22">Dentin Desensitizing Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Desensitizing+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dentin+Permeability%22">Dentin Permeability*</searchLink>/<searchLink fieldCode="MM" term="%22Dentin+Permeability+drug+effects%22">drug effects</searchLink><br /><searchLink fieldCode="MH" term="%22Dentin%22">Dentin</searchLink>/<searchLink fieldCode="MH" term="%22Dentin+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Sodium+Fluoride%22">Sodium Fluoride</searchLink>/<searchLink fieldCode="MH" term="%22Sodium+Fluoride+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Glass+Ionomer+Cements%22">Glass Ionomer Cements</searchLink>/<searchLink fieldCode="MH" term="%22Glass+Ionomer+Cements+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Glass+Ionomer+Cements%22">Glass Ionomer Cements</searchLink>/<searchLink fieldCode="MH" term="%22Glass+Ionomer+Cements+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Calcium+Phosphates%22">Calcium Phosphates</searchLink>/<searchLink fieldCode="MH" term="%22Calcium+Phosphates+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Calcium+Phosphates%22">Calcium Phosphates</searchLink>/<searchLink fieldCode="MH" term="%22Calcium+Phosphates+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Microscopy%2C+Electron%2C+Scanning%22">Microscopy, Electron, Scanning</searchLink> ; <searchLink fieldCode="MH" term="%22In+Vitro+Techniques%22">In Vitro Techniques</searchLink> ; <searchLink fieldCode="MH" term="%22Dentin+Sensitivity%22">Dentin Sensitivity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This in vitro study evaluated the effects of a sodium-fluoride varnish, two surface pre-reacted glass-ionomer (S-PRG)-containing agents, and an experimental glycerol-stabilized calcium phosphate cluster (GCPC) gel on dentin permeability using a custom hydraulic conductance apparatus. Horizontal 1-mm coronal dentin disks were prepared from extracted human molars, conditioned with 2% citric acid, and randomized to ClinPro Fluoride Treatment, PRG Barrier-Coat, PRG Pro-Care Gel, experimental GCPC gel, or distilled-water control (n=10/group). Hydraulic conductance was calculated at 3 psi from the time required for 50 µL of water to pass through each specimen. ClinPro and PRG Barrier-Coat significantly reduced permeability after the first post-treatment evaluation, whereas ClinPro and both PRG agents produced near-zero values after the second evaluation. GCPC yielded a moderate but significant reduction. Scanning electron microscopy findings were consistent with progressive dentinal tubule occlusion.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Dentin hypersensitivity; Dentin permeability; Dentinal fluid flow; Desensitizing agents; Hydraulic conductance
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Dentin Desensitizing Agents)<br />8ZYQ1474W7 (Sodium Fluoride)<br />0 (Glass Ionomer Cements)<br />0 (Calcium Phosphates)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260902 <i>Date Completed: </i>20260927 <i>Latest Revision: </i>20260927
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  Data: 10.4012/dmj.2026-016
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  Data: 42686539
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42686539
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.4012/dmj.2026-016
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 659
    Subjects:
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Sodium Fluoride pharmacology
        Type: general
      – SubjectFull: Glass Ionomer Cements pharmacology
        Type: general
      – SubjectFull: Glass Ionomer Cements chemistry
        Type: general
      – SubjectFull: Calcium Phosphates pharmacology
        Type: general
      – SubjectFull: Calcium Phosphates chemistry
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: In Vitro Techniques
        Type: general
      – SubjectFull: Dentin Sensitivity
        Type: general
      – SubjectFull: Dentin Desensitizing Agents pharmacology
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
    Titles:
      – TitleFull: The effects of desensitizing agents on dentin permeability using a hydraulic conductance device.
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          Name:
            NameFull: Saraç B
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            NameFull: Alkan E
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              M: 09
              Text: 2026 Sep 25
              Type: published
              Y: 2026
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            – Type: issn-electronic
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              Value: 45
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              Value: 5
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            – TitleFull: Dental materials journal
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