Academic Journal
Individual differences in brain dynamics across a social cognition network induced by cortico-cerebellar tDCS in adults with autism spectrum disorder (ASD).
| Τίτλος: | Individual differences in brain dynamics across a social cognition network induced by cortico-cerebellar tDCS in adults with autism spectrum disorder (ASD). |
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| Συγγραφείς: | Tesche CD; Department of Psychology, University of New Mexico, Albuquerque, NM, USA. Electronic address: ctesche@unm.edu., Wilson JE; Department of Psychology, University of New Mexico, Albuquerque, NM, USA; Department of Health and Human Services - Communicative Disorders, Eastern New Mexico University, Portales, NM, USA. |
| Πηγή: | NeuroImage [Neuroimage] 2026 Oct 01; Vol. 339, pp. 122194. Date of Electronic Publication: 2026 Sep 01. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Orlando, FL : Academic Press, c1992- |
| Ιατρικοί όροι (MeSH): | Autism Spectrum Disorder*/physiopathology , Autism Spectrum Disorder*/therapy , Transcranial Direct Current Stimulation*/methods , Cerebellum*/physiopathology , Cerebral Cortex*/physiopathology , Nerve Net*/physiopathology , Social Cognition* , Individuality*, Humans ; Male ; Female ; Young Adult ; Adult ; Magnetoencephalography ; Double-Blind Method ; Adolescent |
| Περίληψη: | Autism spectrum disorder (ASD) is a neurodevelopmental condition with core diagnostic domains of social communication impairments, restricted interests and repetitive behaviors. Idiosyncratic brain organization is a potential hallmark of ASD. Previous transcranial direct current stimulation (tDCS) studies often targeted dorsolateral prefrontal cortex, with changes oin brain dynamics averaged across the cohort. We utilized a magnetoencephalographic (MEG) array to characterize individual differences in brain dynamics induced by cortico-cerebellar tDCS across nodes of a social cognition network. A randomized, sham-controlled, double-blind, within-subject clinical trial was conducted in a cohort of 24 young adults with ASD or high autistic traits. Two separate sessions of computerized social learning activities were combined with verum/sham tDCS, with anodal electrode over right temporoparietal junction (TPJ) and cathode on right deltoid. Following stimulation, theta- and alpha-band activity were evaluated within nodes of a social cognition network: bilateral TPJ, fusiform, medial prefrontal cortex and Crus I/II of cerebellum. Idiosyncratic participant-specific up- and down-regulation of theta- and alpha-band activity occurred across the network. Activity in right Crus I/II, a region inundated by the stimulation current, strongly correlated with the change of activity summed across all cerebral cortical nodes in theta- but not alpha-band. Intrinsic theta-band activity is believed to mediate input/output relationships in cerebellar cortex and to drive synaptic plasticity. These results suggest that theta-band stimulation of cerebellar cortex might be an effective therapy for individuals on the autism spectrum who present with cerebellar hyperactivity. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no financial interests or personal relationships which may be considered as potential competing interests. |
| Contributed Indexing: | Keywords: Autism; Brain networks; Cerebellum; Magnetoencephalography (meg); Social cognition; Theta; Transcranial direct current stimulation (tdcs) |
| Entry Date(s): | Date Created: 20260901 Date Completed: 20260911 Latest Revision: 20260916 |
| Update Code: | 20260917 |
| DOI: | 10.1016/j.neuroimage.2026.122194 |
| PMID: | 42680022 |
| Βάση Δεδομένων: | MEDLINE |
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