Academic Journal
Προβολή σε EDS

Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.
Συγγραφείς: Cong X; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Chen J; Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Han J; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Li L; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Zhou P; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Xu Y; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. oneon2n3@163.com.
Πηγή: Urolithiasis [Urolithiasis] 2026 Sep 01; Vol. 54 (1). Date of Electronic Publication: 2026 Sep 01.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin : Springer, [2013]-
Ιατρικοί όροι (MeSH): Intra-Abdominal Fat*/diagnostic imaging , Intra-Abdominal Fat*/metabolism , Calcium*/urine , Nephrolithiasis*/urine, Humans ; Female ; Middle Aged ; Cross-Sectional Studies ; Retrospective Studies ; Adult ; Male ; Age Factors ; Aged ; Tomography, X-Ray Computed
Περίληψη: Although adiposity is associated with kidney stone disease, the relationship between abdominal fat distribution and urinary calcium excretion remains unclear. We investigated whether the CT-derived visceral-to-subcutaneous fat ratio (VSR) was associated with 24-hour urinary calcium excretion and whether physiologic age modified this association. This retrospective cross-sectional study included 308 adults with nephrolithiasis who underwent preoperative CT, stone removal, and postoperative metabolic evaluation. Participants were stratified into prespecified younger (men aged < 50 years and premenopausal women) and older (men aged ≥ 50 years and postmenopausal women) physiologic-age groups. Multivariable linear regression assessed the association between VSR and urinary calcium excretion and its modification by physiologic age. Results showed that VSR was not associated with urinary calcium excretion in the overall cohort, but its association differed significantly by physiologic age (P for interaction < 0.001). Among younger participants, each 1-unit higher VSR was associated with 2.07 mmol/day greater urinary calcium excretion (95% CI, 1.23-2.90), whereas no significant association was observed in the older group. These findings suggest that the metabolic relevance of visceral fat predominance differs by physiologic age, with a significant association observed only in younger adults. Prospective studies are needed to confirm these findings and determine their clinical implications.
(© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Competing Interests: Declarations. Conflict of interest: The authors declare no conflicts of interest.
References: J Urol. 2017 Nov;198(5):1085-1090. (PMID: 28587918)
J Urol. 2017 Apr;197(4):1084-1089. (PMID: 27746283)
BMC Public Health. 2024 Jul 9;24(1):1827. (PMID: 38982435)
J Urol. 2002 Nov;168(5):1923-7. (PMID: 12394677)
Semin Nephrol. 2008 Mar;28(2):120-32. (PMID: 18359393)
Nutrients. 2020 Mar 15;12(3):. (PMID: 32183500)
Osteoporos Int. 2008 Oct;19(10):1369-78. (PMID: 18633664)
World J Urol. 2017 Sep;35(9):1301-1320. (PMID: 28213860)
Nat Rev Nephrol. 2025 Nov;21(11):794-808. (PMID: 40790363)
Clin Chem Lab Med. 2014 Mar;52(3):337-44. (PMID: 24423579)
Eur Urol Focus. 2017 Feb;3(1):62-71. (PMID: 28720369)
Metabolism. 2021 Feb;115:154456. (PMID: 33259834)
Am J Kidney Dis. 2006 Dec;48(6):905-15. (PMID: 17162145)
Urolithiasis. 2015 Jun;43(3):213-20. (PMID: 25903669)
J Urol. 2013 Oct;190(4):1416-20. (PMID: 23685097)
Diabetes Metab Syndr Obes. 2017 Dec 11;10:505-511. (PMID: 29270027)
Obes Res. 2004 Jan;12(1):106-13. (PMID: 14742848)
Rev Urol. 2020;22(1):17-23. (PMID: 32523467)
Minerva Urol Nefrol. 2018 Aug;70(4):393-400. (PMID: 29856171)
J Clin Invest. 2024 Sep 3;134(17):. (PMID: 39225098)
Horm Mol Biol Clin Investig. 2014 Jan;17(1):13-27. (PMID: 25372727)
Contributed Indexing: Keywords: Nephrolithiasis; Physiologic age; Urinary calcium excretion; Visceral-to-subcutaneous fat ratio
Substance Nomenclature: SY7Q814VUP (Calcium)
Entry Date(s): Date Created: 20260901 Date Completed: 20260901 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s00240-026-02049-3
PMID: 42678531
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://dx.doi.org/doi:10.1007/s00240-026-02049-3
    Name: EDS - Springer Nature Journals (s7799221)
    Category: fullText
    Text: View record at Springer
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=21947236&ISBN=&volume=54&issue=1&date=20260901&spage=&pages=&title=Urolithiasis&atitle=Physiologic%20age%20modifies%20the%20association%20between%20visceral%20fat%20predominance%20and%20urinary%20calcium%20excretion%20in%20adults%20with%20nephrolithiasis.&aulast=Cong%20X&id=DOI:10.1007/s00240-026-02049-3
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 42678531
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Cong+X%22&quot;&gt;Cong X&lt;/searchLink&gt;; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Chen+J%22&quot;&gt;Chen J&lt;/searchLink&gt;; Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Han+J%22&quot;&gt;Han J&lt;/searchLink&gt;; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Li+L%22&quot;&gt;Li L&lt;/searchLink&gt;; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhou+P%22&quot;&gt;Zhou P&lt;/searchLink&gt;; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Xu+Y%22&quot;&gt;Xu Y&lt;/searchLink&gt;; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. oneon2n3@163.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101602699%22&quot;&gt;Urolithiasis&lt;/searchLink&gt; [Urolithiasis] 2026 Sep 01; Vol. 54 (1). &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Sep 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Springer%22&quot;&gt;Springer &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;Germany &lt;i&gt;NLM ID: &lt;/i&gt;101602699 &lt;i&gt;Publication Model: &lt;/i&gt;Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;2194-7236 (Electronic) &lt;i&gt;Linking ISSN: &lt;/i&gt;&lt;searchLink fieldCode=&quot;IS&quot; term=&quot;%2221947228%22&quot;&gt;21947228 &lt;/searchLink&gt;&lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;Urolithiasis &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: &lt;i&gt;Original Publication&lt;/i&gt;: Berlin : Springer, [2013]-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Intra-Abdominal+Fat%22&quot;&gt;Intra-Abdominal Fat*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Intra-Abdominal+Fat+diagnostic+imaging%22&quot;&gt;diagnostic imaging&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Intra-Abdominal+Fat%22&quot;&gt;Intra-Abdominal Fat*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Intra-Abdominal+Fat+metabolism%22&quot;&gt;metabolism&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium%22&quot;&gt;Calcium*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Calcium+urine%22&quot;&gt;urine&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nephrolithiasis%22&quot;&gt;Nephrolithiasis*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Nephrolithiasis+urine%22&quot;&gt;urine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cross-Sectional+Studies%22&quot;&gt;Cross-Sectional Studies&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Retrospective+Studies%22&quot;&gt;Retrospective Studies&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Adult%22&quot;&gt;Adult&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Age+Factors%22&quot;&gt;Age Factors&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%22&quot;&gt;Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Tomography%2C+X-Ray+Computed%22&quot;&gt;Tomography, X-Ray Computed&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Although adiposity is associated with kidney stone disease, the relationship between abdominal fat distribution and urinary calcium excretion remains unclear. We investigated whether the CT-derived visceral-to-subcutaneous fat ratio (VSR) was associated with 24-hour urinary calcium excretion and whether physiologic age modified this association. This retrospective cross-sectional study included 308 adults with nephrolithiasis who underwent preoperative CT, stone removal, and postoperative metabolic evaluation. Participants were stratified into prespecified younger (men aged &amp;lt; 50 years and premenopausal women) and older (men aged ≥ 50 years and postmenopausal women) physiologic-age groups. Multivariable linear regression assessed the association between VSR and urinary calcium excretion and its modification by physiologic age. Results showed that VSR was not associated with urinary calcium excretion in the overall cohort, but its association differed significantly by physiologic age (P for interaction &amp;lt; 0.001). Among younger participants, each 1-unit higher VSR was associated with 2.07 mmol/day greater urinary calcium excretion (95% CI, 1.23-2.90), whereas no significant association was observed in the older group. These findings suggest that the metabolic relevance of visceral fat predominance differs by physiologic age, with a significant association observed only in younger adults. Prospective studies are needed to confirm these findings and determine their clinical implications.&lt;br /&gt; (&#169; 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of interest: The authors declare no conflicts of interest.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: J Urol. 2017 Nov;198(5):1085-1090. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228587918%22&quot;&gt;28587918)&lt;/searchLink&gt;&lt;br /&gt;J Urol. 2017 Apr;197(4):1084-1089. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2227746283%22&quot;&gt;27746283)&lt;/searchLink&gt;&lt;br /&gt;BMC Public Health. 2024 Jul 9;24(1):1827. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238982435%22&quot;&gt;38982435)&lt;/searchLink&gt;&lt;br /&gt;J Urol. 2002 Nov;168(5):1923-7. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2212394677%22&quot;&gt;12394677)&lt;/searchLink&gt;&lt;br /&gt;Semin Nephrol. 2008 Mar;28(2):120-32. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2218359393%22&quot;&gt;18359393)&lt;/searchLink&gt;&lt;br /&gt;Nutrients. 2020 Mar 15;12(3):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2232183500%22&quot;&gt;32183500)&lt;/searchLink&gt;&lt;br /&gt;Osteoporos Int. 2008 Oct;19(10):1369-78. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2218633664%22&quot;&gt;18633664)&lt;/searchLink&gt;&lt;br /&gt;World J Urol. 2017 Sep;35(9):1301-1320. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228213860%22&quot;&gt;28213860)&lt;/searchLink&gt;&lt;br /&gt;Nat Rev Nephrol. 2025 Nov;21(11):794-808. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240790363%22&quot;&gt;40790363)&lt;/searchLink&gt;&lt;br /&gt;Clin Chem Lab Med. 2014 Mar;52(3):337-44. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2224423579%22&quot;&gt;24423579)&lt;/searchLink&gt;&lt;br /&gt;Eur Urol Focus. 2017 Feb;3(1):62-71. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2228720369%22&quot;&gt;28720369)&lt;/searchLink&gt;&lt;br /&gt;Metabolism. 2021 Feb;115:154456. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2233259834%22&quot;&gt;33259834)&lt;/searchLink&gt;&lt;br /&gt;Am J Kidney Dis. 2006 Dec;48(6):905-15. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2217162145%22&quot;&gt;17162145)&lt;/searchLink&gt;&lt;br /&gt;Urolithiasis. 2015 Jun;43(3):213-20. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225903669%22&quot;&gt;25903669)&lt;/searchLink&gt;&lt;br /&gt;J Urol. 2013 Oct;190(4):1416-20. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223685097%22&quot;&gt;23685097)&lt;/searchLink&gt;&lt;br /&gt;Diabetes Metab Syndr Obes. 2017 Dec 11;10:505-511. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229270027%22&quot;&gt;29270027)&lt;/searchLink&gt;&lt;br /&gt;Obes Res. 2004 Jan;12(1):106-13. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2214742848%22&quot;&gt;14742848)&lt;/searchLink&gt;&lt;br /&gt;Rev Urol. 2020;22(1):17-23. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2232523467%22&quot;&gt;32523467)&lt;/searchLink&gt;&lt;br /&gt;Minerva Urol Nefrol. 2018 Aug;70(4):393-400. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229856171%22&quot;&gt;29856171)&lt;/searchLink&gt;&lt;br /&gt;J Clin Invest. 2024 Sep 3;134(17):. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239225098%22&quot;&gt;39225098)&lt;/searchLink&gt;&lt;br /&gt;Horm Mol Biol Clin Investig. 2014 Jan;17(1):13-27. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2225372727%22&quot;&gt;25372727)&lt;/searchLink&gt;
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Nephrolithiasis; Physiologic age; Urinary calcium excretion; Visceral-to-subcutaneous fat ratio
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: SY7Q814VUP (Calcium)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260901 &lt;i&gt;Date Completed: &lt;/i&gt;20260901 &lt;i&gt;Latest Revision: &lt;/i&gt;20261008
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20261008
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1007/s00240-026-02049-3
– Name: AN
  Label: PMID
  Group: ID
  Data: 42678531
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42678531
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00240-026-02049-3
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Cross-Sectional Studies
        Type: general
      – SubjectFull: Retrospective Studies
        Type: general
      – SubjectFull: Adult
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Age Factors
        Type: general
      – SubjectFull: Aged
        Type: general
      – SubjectFull: Tomography, X-Ray Computed
        Type: general
      – SubjectFull: Intra-Abdominal Fat diagnostic imaging
        Type: general
      – SubjectFull: Intra-Abdominal Fat metabolism
        Type: general
      – SubjectFull: Calcium urine
        Type: general
      – SubjectFull: Nephrolithiasis urine
        Type: general
    Titles:
      – TitleFull: Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Cong X
      – PersonEntity:
          Name:
            NameFull: Chen J
      – PersonEntity:
          Name:
            NameFull: Han J
      – PersonEntity:
          Name:
            NameFull: Li L
      – PersonEntity:
          Name:
            NameFull: Zhou P
      – PersonEntity:
          Name:
            NameFull: Xu Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2026 Sep 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2194-7236
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Urolithiasis
              Type: main
ResultId 1