Academic Journal
Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.
| Τίτλος: | Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis. |
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| Συγγραφείς: | Cong X; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Chen J; Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Han J; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Li L; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Zhou P; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Xu Y; Department of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. oneon2n3@163.com. |
| Πηγή: | Urolithiasis [Urolithiasis] 2026 Sep 01; Vol. 54 (1). Date of Electronic Publication: 2026 Sep 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer, [2013]- |
| Ιατρικοί όροι (MeSH): | Intra-Abdominal Fat*/diagnostic imaging , Intra-Abdominal Fat*/metabolism , Calcium*/urine , Nephrolithiasis*/urine, Humans ; Female ; Middle Aged ; Cross-Sectional Studies ; Retrospective Studies ; Adult ; Male ; Age Factors ; Aged ; Tomography, X-Ray Computed |
| Περίληψη: | Although adiposity is associated with kidney stone disease, the relationship between abdominal fat distribution and urinary calcium excretion remains unclear. We investigated whether the CT-derived visceral-to-subcutaneous fat ratio (VSR) was associated with 24-hour urinary calcium excretion and whether physiologic age modified this association. This retrospective cross-sectional study included 308 adults with nephrolithiasis who underwent preoperative CT, stone removal, and postoperative metabolic evaluation. Participants were stratified into prespecified younger (men aged < 50 years and premenopausal women) and older (men aged ≥ 50 years and postmenopausal women) physiologic-age groups. Multivariable linear regression assessed the association between VSR and urinary calcium excretion and its modification by physiologic age. Results showed that VSR was not associated with urinary calcium excretion in the overall cohort, but its association differed significantly by physiologic age (P for interaction < 0.001). Among younger participants, each 1-unit higher VSR was associated with 2.07 mmol/day greater urinary calcium excretion (95% CI, 1.23-2.90), whereas no significant association was observed in the older group. These findings suggest that the metabolic relevance of visceral fat predominance differs by physiologic age, with a significant association observed only in younger adults. Prospective studies are needed to confirm these findings and determine their clinical implications. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no conflicts of interest. |
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| Contributed Indexing: | Keywords: Nephrolithiasis; Physiologic age; Urinary calcium excretion; Visceral-to-subcutaneous fat ratio |
| Substance Nomenclature: | SY7Q814VUP (Calcium) |
| Entry Date(s): | Date Created: 20260901 Date Completed: 20260901 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s00240-026-02049-3 |
| PMID: | 42678531 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2194-7236 |
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| DOI: | 10.1007/s00240-026-02049-3 |