Academic Journal
Causal relationships between oral-gut microbiome and bone neoplasm-related phenotypes: Insights from bidirectional Mendelian randomization.
| Τίτλος: | Causal relationships between oral-gut microbiome and bone neoplasm-related phenotypes: Insights from bidirectional Mendelian randomization. |
|---|---|
| Συγγραφείς: | Zou Q; Department of Medical Imaging, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Neurodegenerative Diseases, Changsha Medical University, Changsha, Hunan, China., Sun F; Department of Orthopaedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Xu W; Department of Orthopaedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Peng D; Department of Orthopaedic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Jiang Z; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Liao H; Department of Medical Imaging, Changsha Medical University, Changsha, Hunan, China. |
| Πηγή: | Medicine [Medicine (Baltimore)] 2026 Aug 28; Vol. 105 (35), pp. e50422. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| Ιατρικοί όροι (MeSH): | Gastrointestinal Microbiome*/genetics , Saliva*/microbiology , Bone Neoplasms*/genetics , Bone Neoplasms*/microbiology , Mouth*/microbiology , Mendelian Randomization Analysis*, Humans ; Phenotype ; Genome-Wide Association Study ; Microbiota |
| Περίληψη: | The human oral and gut microbiota are the 4 largest microbial communities in the body and play crucial roles in maintaining homeostasis and influencing disease. Observational studies have suggested links between these microbiota and bone neoplasm-related phenotypes, but establishing causality has been challenging due to confounding factors and reverse causality. We conducted a bidirectional, 2-sample Mendelian randomization (MR) study to investigate evidence consistent with a potential causal association between the saliva and gut microbiota and various bone neoplasm-related phenotypes. Genetic instruments for saliva and gut microbiota were sourced from large genome-wide association studies. Inverse variance weighted was the primary MR method, supplemented by 4 other MR techniques. Sensitivity analyses, including MR-Egger regression, were performed to assess pleiotropy and heterogeneity. In the forward MR analysis, Veillonella parvula from the saliva microbiota was associated with a decreased risk of bone and connective tissue neoplasms (β: -0.236, 95% CI: [-0.275, -0.197], P = 8.20E-33). MR analyses identified genetically predicted associations between several microbial taxa and bone neoplasm-related phenotypes. Reverse MR analyses showed that genetic liability to bone neoplasm-related phenotypes was associated with variation in the composition of the oral (e.g., Order Bacteroidales, Rothia mucilaginosa) and gut microbiota (e.g., Class Methanobacteria, Genus Eubacterium oxidoreducens group). Sensitivity analyses confirmed the robustness of these findings, as no statistical evidence of substantial heterogeneity or directional horizontal pleiotropy was detected. This study provides genetic evidence supporting a bidirectional causal relationship between specific saliva and gut microbiota and bone neoplasm-related phenotypes. Our findings identify several microbial taxa as potential candidates for future biomarker development and therapeutic investigation in bone neoplasm-related phenotypes. However, these genetically informed associations require further mechanistic, experimental, and prospective clinical validation before clinical application. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, LLC.) |
| Competing Interests: | The authors have no conflicts of interest to disclose. |
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| Contributed Indexing: | Keywords: Mendelian randomization; Reverse Mendelian randomization; bone neoplasm-related phenotypes; gut microbiota; oral microbiota |
| Entry Date(s): | Date Created: 20260901 Date Completed: 20260901 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| PubMed Central ID: | PMC13529192 |
| DOI: | 10.1097/MD.0000000000050422 |
| PMID: | 42675685 |
| Βάση Δεδομένων: | MEDLINE |
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