Academic Journal
MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers.
| Τίτλος: | MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers. |
|---|---|
| Συγγραφείς: | Yueh TC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.; National Defense Medical University, Taipei, Taiwan, R.O.C.; Department of Healthcare Industry Technology Development and Management, National Chin-Yi University of Technology, Taichung, Taiwan, R.O.C., Wu MH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.; National Defense Medical University, Taipei, Taiwan, R.O.C., Yang MD; Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C., Lu MC; Department of Clinical Nutrition, China Medical University Hospital, Taichung, Taiwan, R.O.C., Shao YC; Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Ke TW; Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.; Office of Research and Development, Asia University, Taichung, Taiwan, R.O.C., Wang ZH; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C., Chen CA; Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.; National Defense Medical University, Taipei, Taiwan, R.O.C., Tsai CW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C., Bau DT; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; 013280@tool.caaumed.org.tw.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.; Office of Research and Development, Asia University, Taichung, Taiwan, R.O.C., Chang WS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; 031002@tool.caaumed.org.tw.; Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. |
| Πηγή: | Anticancer research [Anticancer Res] 2026 Sep; Vol. 46 (9), pp. 4867-4880. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
| Ιατρικοί όροι (MeSH): | Matrix Metalloproteinase 2*/genetics , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/genetics , Alcohol Drinking*/adverse effects , Alcohol Drinking*/genetics , Smoking*/adverse effects , Smoking*/genetics , Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Asian People/genetics ; Humans ; Male ; Middle Aged ; Case-Control Studies ; Taiwan ; Risk Factors ; Genotype ; Female ; Aged ; Promoter Regions, Genetic ; Gene-Environment Interaction |
| Περίληψη: | Background/aim: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Matrix metalloproteinase-2 (MMP-2) plays an important role in extracellular matrix remodeling and HCC progression. This study investigated the associations of two functional MMP-2 promoter polymorphisms, rs243865 and rs2285053, with HCC susceptibility in a Taiwanese population and explored their potential interactions with environmental risk factors. Materials and Methods: A hospital-based case-control study was conducted at China Medical University Hospital (Taichung, Taiwan), involving 298 HCC patients and 889 age- and sex-matched cancer-free controls recruited in Taiwan. MMP-2 rs243865 and rs2285053 genotypes were determined utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Stratified analyses were used to explore their potential interactions between MMP-2 genotypes and environmental factors including sex, smoking and alcohol drinking status. Results: No significant association was observed between HCC susceptibility and either rs243865 (CT+TT versus CC: odds ratio (OR)=1.20, 95% confidence interval (CI)=0.87-1.66, p=0.2944] or rs2285053 (CT+TT versus CC: OR=1.12, 95% CI=0.86-1.46, p=0.4219). Similarly, allelic analyses revealed no significant effects. Interestingly, stratified analyses demonstrated significant gene-environment interactions for rs243865. Male carriers of the TT genotype exhibited an increased HCC risk (OR=3.24, 95% CI=1.12-9.37, p=0.0488). Among smokers, the TT genotype was associated with a markedly elevated risk (OR=6.46, 95% CI=1.65-25.29, p=0.0055), while alcohol drinkers carrying the TT genotype showed the highest susceptibility (OR=9.69, 95% CI=1.99-47.13, p=0.0022). No significant association was found for rs2285053 genotype in any genetic variant and subgroup. Conclusion: Although MMP-2 rs243865 and rs2285053 do not independently determine HCC susceptibility, rs243865 T allele may serve as a genetic biomarker for identifying Taiwanese males, smokers, and alcohol drinkers at elevated risk of HCC. These findings highlight the importance of gene-environment interactions in hepatocarcinogenesis and support the incorporation of genetic information into personalized HCC risk assessment and prediction strategies. (Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
| Contributed Indexing: | Keywords: Age; Taiwan; genotype; hepatocellular carcinoma; matrix metalloproteinase-2; polymorphism; sex |
| Substance Nomenclature: | EC 3.4.24.24 (Matrix Metalloproteinase 2) EC 3.4.24.24 (MMP2 protein, human) |
| Entry Date(s): | Date Created: 20260831 Date Completed: 20260831 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| DOI: | 10.21873/anticanres.18339 |
| PMID: | 42674711 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!